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    Pi4ka phosphatidylinositol 4-kinase alpha [ Mus musculus (house mouse) ]

    Gene ID: 224020, updated on 23-Jun-2021

    Summary

    Official Symbol
    Pi4kaprovided by MGI
    Official Full Name
    phosphatidylinositol 4-kinase alphaprovided by MGI
    Primary source
    MGI:MGI:2448506
    See related
    Ensembl:ENSMUSG00000041720
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Pik; Pik4ca
    Expression
    Ubiquitous expression in cortex adult (RPKM 25.4), frontal lobe adult (RPKM 25.2) and 28 other tissues See more
    Orthologs
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    Genomic context

    See Pi4ka in Genome Data Viewer
    Location:
    16; 16 A3
    Exon count:
    57
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 16 NC_000082.7 (17098215..17224178, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 16 NC_000082.6 (17280351..17406314, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 16 NC_000082.5 (17280444..17406407, complement)

    Chromosome 16 - NC_000082.7Genomic Context describing neighboring genes Neighboring gene hypermethylated in cancer 2 Neighboring gene transmembrane protein 191C Neighboring gene serine (or cysteine) peptidase inhibitor, clade D, member 1 Neighboring gene predicted gene, 24927 Neighboring gene poly(A) binding protein, cytoplasmic 1 pseudogene Neighboring gene synaptosomal-associated protein 29 Neighboring gene v-crk avian sarcoma virus CT10 oncogene homolog-like Neighboring gene apoptosis-inducing factor, mitochondrion-associated 3

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Gene trapped (2) 
    • Targeted (8)  1 citation
    • Chemically induced (ENU) (2) 

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables 1-phosphatidylinositol 4-kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables 1-phosphatidylinositol 4-kinase activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    enables 1-phosphatidylinositol 4-kinase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables kinase activity ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables phosphatidylinositol kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    located_in Golgi-associated vesicle membrane ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    phosphatidylinositol 4-kinase alpha
    Names
    PI4-kinase alpha
    PI4K-alpha
    phosphatidylinositol 4-kinase, catalytic, alpha polypeptide
    ptdIns-4-kinase alpha
    NP_001001983.2
    NP_001360884.1
    XP_006522099.1
    XP_006522100.1
    XP_030104929.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001001983.2NP_001001983.2  phosphatidylinositol 4-kinase alpha isoform 2

      Status: VALIDATED

      Source sequence(s)
      BC075629, BU700531, CF747564
      Consensus CDS
      CCDS37271.1
      UniProtKB/Swiss-Prot
      E9Q3L2
      UniProtKB/TrEMBL
      A0A140T8I9
      Related
      ENSMUSP00000036162.6, ENSMUST00000036161.12
      Conserved Domains (2) summary
      cd00871
      Location:14891664
      PI4Ka; Phosphoinositide 4-kinase(PI4K), accessory domain (PIK domain); PIK domain is conserved in PI3 and PI4-kinases. Its role is unclear but it has been suggested to be involved in substrate presentation. PI4K phosphorylates hydroxylgroup at position 4 on the ...
      cd05167
      Location:17252043
      PI4Kc_III_alpha; Catalytic domain of Type III Phosphoinositide 4-kinase alpha
    2. NM_001373955.1NP_001360884.1  phosphatidylinositol 4-kinase alpha isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC110573, KY499708
      Conserved Domains (2) summary
      cd00871
      Location:15501725
      PI4Ka; Phosphoinositide 4-kinase(PI4K), accessory domain (PIK domain); PIK domain is conserved in PI3 and PI4-kinases. Its role is unclear but it has been suggested to be involved in substrate presentation. PI4K phosphorylates hydroxylgroup at position 4 on the ...
      cd05167
      Location:17862104
      PI4Kc_III_alpha; Catalytic domain of Type III Phosphoinositide 4-kinase alpha

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000082.7 Reference GRCm39 C57BL/6J

      Range
      17098215..17224178 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030249069.2XP_030104929.1  phosphatidylinositol 4-kinase alpha isoform X1

      Conserved Domains (2) summary
      cd00871
      Location:13811556
      PI4Ka; Phosphoinositide 4-kinase(PI4K), accessory domain (PIK domain); PIK domain is conserved in PI3 and PI4-kinases. Its role is unclear but it has been suggested to be involved in substrate presentation. PI4K phosphorylates hydroxylgroup at position 4 on the ...
      cd05167
      Location:16171935
      PI4Kc_III_alpha; Catalytic domain of Type III Phosphoinositide 4-kinase alpha
    2. XM_006522037.3XP_006522100.1  phosphatidylinositol 4-kinase alpha isoform X3

      Conserved Domains (2) summary
      cd00871
      Location:616791
      PI4Ka; Phosphoinositide 4-kinase(PI4K), accessory domain (PIK domain); PIK domain is conserved in PI3 and PI4-kinases. Its role is unclear but it has been suggested to be involved in substrate presentation. PI4K phosphorylates hydroxylgroup at position 4 on the ...
      cd05167
      Location:8521170
      PI4Kc_III_alpha; Catalytic domain of Type III Phosphoinositide 4-kinase alpha
    3. XM_006522036.5XP_006522099.1  phosphatidylinositol 4-kinase alpha isoform X2

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