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    Spidr scaffolding protein involved in DNA repair [ Mus musculus (house mouse) ]

    Gene ID: 224008, updated on 31-Jan-2019

    Summary

    Official Symbol
    Spidrprovided by MGI
    Official Full Name
    scaffolding protein involved in DNA repairprovided by MGI
    Primary source
    MGI:MGI:1924834
    See related
    Ensembl:ENSMUSG00000041974
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Kiaa0146; 2310008H04Rik
    Expression
    Ubiquitous expression in CNS E11.5 (RPKM 4.4), limb E14.5 (RPKM 3.5) and 28 other tissues See more
    Orthologs

    Genomic context

    See Spidr in Genome Data Viewer
    Location:
    16; 16 A2
    Exon count:
    21
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 16 NC_000082.6 (15889224..16146851, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 16 NC_000082.5 (15889320..16146926, complement)

    Chromosome 16 - NC_000082.6Genomic Context describing neighboring genes Neighboring gene mitotic spindle organizing protein 2 Neighboring gene predicted gene, 41425 Neighboring gene 60S ribosomal protein L30-like Neighboring gene CCAAT/enhancer binding protein (C/EBP), delta Neighboring gene predicted gene 10121 Neighboring gene folate receptor 1 (adult) pseudogene Neighboring gene ribosomal protein L29, pseudogene 4 Neighboring gene cell division cycle associated 7 pseudogene

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (2) 

    Pathways from BioSystems

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • MGC30630, MGC115787

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    molecular_function ND
    No biological Data available
    more info
     
    Process Evidence Code Pubs
    DNA recombination IEA
    Inferred from Electronic Annotation
    more info
     
    DNA repair IEA
    Inferred from Electronic Annotation
    more info
     
    cellular response to DNA damage stimulus ISO
    Inferred from Sequence Orthology
    more info
     
    cellular response to camptothecin ISO
    Inferred from Sequence Orthology
    more info
     
    cellular response to hydroxyurea ISO
    Inferred from Sequence Orthology
    more info
     
    cellular response to ionizing radiation ISO
    Inferred from Sequence Orthology
    more info
     
    double-strand break repair via homologous recombination IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    double-strand break repair via homologous recombination ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of double-strand break repair ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of protein complex assembly ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of double-strand break repair via homologous recombination ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of establishment of protein localization to chromosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    regulation of establishment of protein localization to chromosome ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    nuclear chromosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    nuclear chromosome ISO
    Inferred from Sequence Orthology
    more info
     
    nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    nucleus IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    DNA repair-scaffolding protein
    Names
    scaffolding protein involved i DNA repair

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001355731.1NP_001342660.1  DNA repair-scaffolding protein isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC113329, AC154586
      Conserved Domains (2) summary
      pfam14950
      Location:158
      DUF4502; Domain of unknown function (DUF4502)
      pfam14951
      Location:208588
      DUF4503; Domain of unknown function (DUF4503)
    2. NM_146068.4NP_666180.2  DNA repair-scaffolding protein isoform 1

      See identical proteins and their annotated locations for NP_666180.2

      Status: VALIDATED

      Source sequence(s)
      AK044836, AK146053, BC089026
      Consensus CDS
      CCDS27980.1
      UniProtKB/Swiss-Prot
      Q8BGX7
      Related
      ENSMUSP00000038820.7, ENSMUST00000040248.8
      Conserved Domains (2) summary
      pfam14950
      Location:11390
      DUF4502; Domain of unknown function (DUF4502)
      pfam14951
      Location:540920
      DUF4503; Domain of unknown function (DUF4503)

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000082.6 Reference GRCm38.p4 C57BL/6J

      Range
      15889224..16146851 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017316948.1XP_017172437.1  DNA repair-scaffolding protein isoform X2

      Conserved Domains (2) summary
      pfam14950
      Location:158
      DUF4502; Domain of unknown function (DUF4502)
      pfam14951
      Location:208588
      DUF4503; Domain of unknown function (DUF4503)
    2. XM_017316946.1XP_017172435.1  DNA repair-scaffolding protein isoform X1

    3. XM_017316947.1XP_017172436.1  DNA repair-scaffolding protein isoform X1

    RNA

    1. XR_001781811.1 RNA Sequence

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