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    Senp1 SUMO1/sentrin specific peptidase 1 [ Mus musculus (house mouse) ]

    Gene ID: 223870, updated on 6-Sep-2021

    Summary

    Official Symbol
    Senp1provided by MGI
    Official Full Name
    SUMO1/sentrin specific peptidase 1provided by MGI
    Primary source
    MGI:MGI:2445054
    See related
    Ensembl:ENSMUSG00000033075
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    suPr-2; D15Ertd528; D15Ertd528e; 2310046A20Rik; E330036L07Rik
    Expression
    Ubiquitous expression in testis adult (RPKM 9.4), thymus adult (RPKM 9.2) and 28 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Senp1 in Genome Data Viewer
    Location:
    15 F1; 15 54.04 cM
    Exon count:
    22
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 15 NC_000081.7 (97936625..97991625, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 15 NC_000081.6 (98038744..98093569, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 15 NC_000081.5 (97871660..97923836, complement)

    Chromosome 15 - NC_000081.7Genomic Context describing neighboring genes Neighboring gene collagen, type II, alpha 1 Neighboring gene predicted gene, 46536 Neighboring gene predicted gene, 41395 Neighboring gene predicted gene, 25668 Neighboring gene phosphofructokinase, muscle Neighboring gene ankyrin repeat and SOCS box-containing 8 Neighboring gene coiled-coil domain containing 184

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • MGC27975

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables SUMO-specific endopeptidase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables SUMO-specific isopeptidase activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    enables SUMO-specific protease activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables SUMO-specific protease activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables cysteine-type peptidase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables peptidase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    located_in focal adhesion ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nuclear membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 

    General protein information

    Preferred Names
    sentrin-specific protease 1
    Names
    SUMO-1 protease 2
    SUMO1/sentrin specific protease 1
    sentrin/SUMO-specific protease SENP1
    NP_001366502.1
    NP_659100.1
    XP_006520943.1
    XP_006520945.1
    XP_006520946.1
    XP_006520947.1
    XP_030104385.1
    XP_030104386.1
    XP_036015277.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001379573.1NP_001366502.1  sentrin-specific protease 1 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC113444
      Conserved Domains (2) summary
      PRK04863
      Location:381475
      mukB; chromosome partition protein MukB
      cl23802
      Location:448670
      Peptidase_C48; Ulp1 protease family, C-terminal catalytic domain
    2. NM_144851.5NP_659100.1  sentrin-specific protease 1 isoform 2

      See identical proteins and their annotated locations for NP_659100.1

      Status: VALIDATED

      Source sequence(s)
      AK009838, AK028565, AK054521, AW490919, BF453574, CX203962
      Consensus CDS
      CCDS49717.1
      UniProtKB/Swiss-Prot
      P59110
      Related
      ENSMUSP00000046598.9, ENSMUST00000044189.16
      Conserved Domains (1) summary
      cl23802
      Location:416638
      Peptidase_C48; Ulp1 protease family, C-terminal catalytic domain

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000081.7 Reference GRCm39 C57BL/6J

      Range
      97936625..97991625 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006520882.5XP_006520945.1  sentrin-specific protease 1 isoform X2

      UniProtKB/TrEMBL
      M0QWX4
      Related
      ENSMUSP00000138056.2, ENSMUST00000180657.2
      Conserved Domains (2) summary
      PRK04863
      Location:375469
      mukB; chromosome partition protein MukB
      cl23802
      Location:442664
      Peptidase_C48; Ulp1 protease family, C-terminal catalytic domain
    2. XM_006520884.5XP_006520947.1  sentrin-specific protease 1 isoform X4

      Conserved Domains (1) summary
      COG5160
      Location:259498
      ULP1; Protease, Ulp1 family [Posttranslational modification, protein turnover, chaperones]
    3. XM_006520883.3XP_006520946.1  sentrin-specific protease 1 isoform X3

      Conserved Domains (2) summary
      COG5160
      Location:285524
      ULP1; Protease, Ulp1 family [Posttranslational modification, protein turnover, chaperones]
      PRK04863
      Location:233327
      mukB; chromosome partition protein MukB
    4. XM_006520880.3XP_006520943.1  sentrin-specific protease 1 isoform X1

      Conserved Domains (2) summary
      PRK04863
      Location:407501
      mukB; chromosome partition protein MukB
      cl23802
      Location:474696
      Peptidase_C48; Ulp1 protease family, C-terminal catalytic domain
    5. XM_030248526.1XP_030104386.1  sentrin-specific protease 1 isoform X4

      Conserved Domains (1) summary
      COG5160
      Location:259498
      ULP1; Protease, Ulp1 family [Posttranslational modification, protein turnover, chaperones]
    6. XM_030248525.1XP_030104385.1  sentrin-specific protease 1 isoform X3

      Conserved Domains (2) summary
      COG5160
      Location:285524
      ULP1; Protease, Ulp1 family [Posttranslational modification, protein turnover, chaperones]
      PRK04863
      Location:233327
      mukB; chromosome partition protein MukB
    7. XM_036159384.1XP_036015277.1  sentrin-specific protease 1 isoform X4

      Conserved Domains (1) summary
      COG5160
      Location:259498
      ULP1; Protease, Ulp1 family [Posttranslational modification, protein turnover, chaperones]
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