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    Baz1b bromodomain adjacent to zinc finger domain, 1B [ Mus musculus (house mouse) ]

    Gene ID: 22385, updated on 31-Jan-2019

    Summary

    Official Symbol
    Baz1bprovided by MGI
    Official Full Name
    bromodomain adjacent to zinc finger domain, 1Bprovided by MGI
    Primary source
    MGI:MGI:1353499
    See related
    Ensembl:ENSMUSG00000002748
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    WSTF; C87820; Wbscr9
    Expression
    Ubiquitous expression in CNS E11.5 (RPKM 36.9), limb E14.5 (RPKM 19.4) and 28 other tissues See more
    Orthologs

    Genomic context

    See Baz1b in Genome Data Viewer
    Location:
    5; 5 G2
    Exon count:
    20
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 5 NC_000071.6 (135187323..135246131)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 5 NC_000071.5 (135663193..135721999)

    Chromosome 5 - NC_000071.6Genomic Context describing neighboring genes Neighboring gene transducin (beta)-like 2 Neighboring gene B cell CLL/lymphoma 7B Neighboring gene frizzled class receptor 9 Neighboring gene FK506 binding protein 6

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from BioSystems

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    histone binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    histone kinase activity ISO
    Inferred from Sequence Orthology
    more info
     
    kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    non-membrane spanning protein tyrosine kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein tyrosine kinase activity ISO
    Inferred from Sequence Orthology
    more info
     
    transferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    cellular response to DNA damage stimulus ISO
    Inferred from Sequence Orthology
    more info
     
    chromatin assembly or disassembly IDA
    Inferred from Direct Assay
    more info
    PubMed 
    chromatin remodeling IDA
    Inferred from Direct Assay
    more info
    PubMed 
    chromatin remodeling NAS
    Non-traceable Author Statement
    more info
    PubMed 
    histone phosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    phosphorylation IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    condensed chromosome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nuclear body ISO
    Inferred from Sequence Orthology
    more info
     
    colocalizes_with nuclear replication fork ISO
    Inferred from Sequence Orthology
    more info
     
    nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    pericentric heterochromatin IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    tyrosine-protein kinase BAZ1B
    Names
    Williams-Beuren syndrome chromosome region 9 homolog
    bromodomain adjacent to zinc finger domain protein 1B
    bromodomain adjacent to zinc finger domain, 1B; Williams-Beuren syndrome chromosome region 9 homolog
    williams syndrome transcription factor homolog
    williams-Beuren syndrome chromosomal region 9 protein homolog
    NP_035844.2
    XP_011239182.1

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_011714.2NP_035844.2  tyrosine-protein kinase BAZ1B

      See identical proteins and their annotated locations for NP_035844.2

      Status: VALIDATED

      Source sequence(s)
      AF084480, AK017894, AK037737, BF463363, BM114461
      Consensus CDS
      CCDS19736.1
      UniProtKB/Swiss-Prot
      Q9Z277
      Related
      ENSMUSP00000002825.5, ENSMUST00000002825.5
      Conserved Domains (7) summary
      cd05505
      Location:13401436
      Bromo_WSTF_like; Bromodomain; Williams syndrome transcription factor-like subfamily (WSTF-like). The Williams-Beuren syndrome deletion transcript 9 is a putative transcriptional regulator. WSTF was found to play a role in vitamin D-mediated transcription as part of two ...
      smart00571
      Location:605669
      DDT; domain in different transcription and chromosome remodeling factors
      cd15628
      Location:11861231
      PHD_BAZ1B; PHD finger found in bromodomain adjacent to zinc finger domain protein 1B (BAZ1B)
      pfam10537
      Location:21120
      WAC_Acf1_DNA_bd; ATP-utilizing chromatin assembly and remodelling N-terminal
      pfam15612
      Location:725770
      WHIM1; WSTF, HB1, Itc1p, MBD9 motif 1
      pfam15613
      Location:900928
      WHIM2; WSTF, HB1, Itc1p, MBD9 motif 2
      pfam15614
      Location:9911029
      WHIM3; WSTF, HB1, Itc1p, MBD9 motif 3

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000071.6 Reference GRCm38.p4 C57BL/6J

      Range
      135187323..135246131
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011240880.2XP_011239182.1  tyrosine-protein kinase BAZ1B isoform X1

      UniProtKB/Swiss-Prot
      Q9Z277
      Conserved Domains (6) summary
      cd05505
      Location:10421138
      Bromo_WSTF_like; Bromodomain; Williams syndrome transcription factor-like subfamily (WSTF-like). The Williams-Beuren syndrome deletion transcript 9 is a putative transcriptional regulator. WSTF was found to play a role in vitamin D-mediated transcription as part of two ...
      smart00571
      Location:307371
      DDT; domain in different transcription and chromosome remodeling factors
      cd15628
      Location:888933
      PHD_BAZ1B; PHD finger found in bromodomain adjacent to zinc finger domain protein 1B (BAZ1B)
      pfam15612
      Location:427472
      WHIM1; WSTF, HB1, Itc1p, MBD9 motif 1
      pfam15613
      Location:602630
      WHIM2; WSTF, HB1, Itc1p, MBD9 motif 2
      pfam15614
      Location:693731
      WHIM3; WSTF, HB1, Itc1p, MBD9 motif 3
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