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    Eif4h eukaryotic translation initiation factor 4H [ Mus musculus (house mouse) ]

    Gene ID: 22384, updated on 31-Jan-2019

    Summary

    Official Symbol
    Eif4hprovided by MGI
    Official Full Name
    eukaryotic translation initiation factor 4Hprovided by MGI
    Primary source
    MGI:MGI:1341822
    See related
    Ensembl:ENSMUSG00000040731
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Ef4h; Wscr1; Wbscr1; eIF-4H; AU018978; D5Ertd355e; E430026L18Rik
    Summary
    This gene encodes eukaryotic translation initiation factor 4H (eIF4H) that plays a critical role in the process of protein synthesis. The encoded protein is an RNA-binding protein that, in concert with other translation initiation factors, helps unwind the 5' cap-proximal region of mRNA to prepare it for ribosomal attachment. Mice lacking the encoded protein displayed growth retardation with a significant reduction of body weight, a smaller brain volume and altered brain morphology. Behaviorally, mice lacking the encoded protein exhibit severe impairments of fear-related associative learning and memory formation. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Aug 2015]
    Expression
    Ubiquitous expression in CNS E11.5 (RPKM 110.9), large intestine adult (RPKM 109.6) and 28 other tissues See more
    Orthologs

    Genomic context

    See Eif4h in Genome Data Viewer
    Location:
    5 G2; 5 74.71 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 5 NC_000071.6 (134619872..134639409, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 5 NC_000071.5 (135095746..135115198, complement)

    Chromosome 5 - NC_000071.6Genomic Context describing neighboring genes Neighboring gene replication factor C (activator 1) 2 Neighboring gene linker for activation of T cells family, member 2 Neighboring gene LIM-domain containing, protein kinase Neighboring gene predicted gene 10369 Neighboring gene elastin Neighboring gene predicted gene, 30003

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Gene trapped (1) 
    • Targeted (2) 

    Pathways from BioSystems

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    RNA binding IEA
    Inferred from Electronic Annotation
    more info
     
    RNA strand annealing activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    RNA strand-exchange activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    nucleic acid binding IEA
    Inferred from Electronic Annotation
    more info
     
    ribosomal small subunit binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    translation initiation factor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    Process Evidence Code Pubs
    cytoplasmic translation IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    developmental growth IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    eukaryotic translation initiation factor 4F complex assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    formation of translation preinitiation complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    sexual reproduction IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    translation IEA
    Inferred from Electronic Annotation
    more info
     
    translational initiation IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    polysome IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 

    General protein information

    Preferred Names
    eukaryotic translation initiation factor 4H
    Names
    williams-Beuren syndrome chromosomal region 1 protein homolog

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001312867.1NP_001299796.1  eukaryotic translation initiation factor 4H isoform 2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) lacks an alternate in-frame exon in the 3' coding region, compared to variant 1. The encoded protein (isoform 2) is shorter than isoform 1.
      Source sequence(s)
      AC166938, AK169407, CF750202, CJ158448
      Consensus CDS
      CCDS84968.1
      UniProtKB/Swiss-Prot
      Q9WUK2
      UniProtKB/TrEMBL
      Q3TG58
      Related
      ENSMUSP00000048833.9, ENSMUST00000036125.9
      Conserved Domains (2) summary
      cd12401
      Location:41116
      RRM_eIF4H; RNA recognition motif in eukaryotic translation initiation factor 4H (eIF-4H) and similar proteins
      cl25887
      Location:40207
      RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
    2. NM_033561.2NP_291039.1  eukaryotic translation initiation factor 4H isoform 1

      See identical proteins and their annotated locations for NP_291039.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer protein (isoform 1).
      Source sequence(s)
      AC166938, AK045004, CF750202, CJ158448
      Consensus CDS
      CCDS19723.1
      UniProtKB/Swiss-Prot
      Q9WUK2
      UniProtKB/TrEMBL
      Q564E5
      Related
      ENSMUSP00000143910.1, ENSMUST00000202622.3
      Conserved Domains (2) summary
      cd12401
      Location:41116
      RRM_eIF4H; RNA recognition motif in eukaryotic translation initiation factor 4H (eIF-4H) and similar proteins
      cl25887
      Location:40227
      RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000071.6 Reference GRCm38.p4 C57BL/6J

      Range
      134619872..134639409 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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