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    Fmnl3 formin-like 3 [ Mus musculus (house mouse) ]

    Gene ID: 22379, updated on 23-Jun-2021

    Summary

    Official Symbol
    Fmnl3provided by MGI
    Official Full Name
    formin-like 3provided by MGI
    Primary source
    MGI:MGI:109569
    See related
    Ensembl:ENSMUSG00000023008
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Wbp; Wbp3; FBP11; mKIAA2014; 2700073B04Rik
    Expression
    Ubiquitous expression in lung adult (RPKM 22.2), ovary adult (RPKM 18.2) and 27 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Fmnl3 in Genome Data Viewer
    Location:
    15; 15 F1
    Exon count:
    28
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 15 NC_000081.7 (99215091..99268375, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 15 NC_000081.6 (99317210..99370521, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 15 NC_000081.5 (99147653..99200897, complement)

    Chromosome 15 - NC_000081.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 1700120C14 gene Neighboring gene predicted gene, 25999 Neighboring gene family with sequence similarity 186, member B Neighboring gene pre-mRNA processing factor 40B Neighboring gene predicted gene, 22951 Neighboring gene transmembrane BAX inhibitor motif containing 6 Neighboring gene VISTA enhancer mm1635

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (2) 

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables GTPase activating protein binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables actin binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables actin filament binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables small GTPase binding IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    involved_in actin cytoskeleton organization IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within angiogenesis IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cell migration IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in cell migration ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cellular component organization IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cortical actin cytoskeleton organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in cytoskeleton organization ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within multicellular organism development IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in regulation of cell morphogenesis IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in regulation of cell shape IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in regulation of cell shape ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    located_in Golgi apparatus ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    located_in intracellular membrane-bounded organelle ISO
    Inferred from Sequence Orthology
    more info
     
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    formin-like protein 3
    Names
    WW domain binding protein 3
    formin-like 3 protein

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001310622.1NP_001297551.1  formin-like protein 3 isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks the penultimate exon compared to variant 1, which results in a frame-shift and a shorter isoform (2) with a distinct C-terminus compared to isoform 1.
      Source sequence(s)
      AC118646, AK163361, AU042388, BC131961
      Consensus CDS
      CCDS79409.1
      UniProtKB/Swiss-Prot
      Q6ZPF4
      UniProtKB/TrEMBL
      D3Z7A7
      Related
      ENSMUSP00000113094.2, ENSMUST00000120633.2
      Conserved Domains (3) summary
      pfam02181
      Location:561926
      FH2; Formin Homology 2 Domain
      pfam06367
      Location:281472
      Drf_FH3; Diaphanous FH3 Domain
      pfam06371
      Location:26278
      Drf_GBD; Diaphanous GTPase-binding Domain
    2. NM_001310623.1NP_001297552.1  formin-like protein 3 isoform 3

      See identical proteins and their annotated locations for NP_001297552.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) lacks an in-frame coding exon in the mid region and the penultimate exon compared to variant 1. The resulting isoform (3) is shorter missing an internal protein segment and with a distinct C-terminus compared to isoform 1.
      Source sequence(s)
      AC118646, AU042388, BC131961
      Consensus CDS
      CCDS79408.1
      UniProtKB/Swiss-Prot
      Q6ZPF4
      Related
      ENSMUSP00000079984.8, ENSMUST00000081224.14
      Conserved Domains (3) summary
      pfam02181
      Location:510875
      FH2; Formin Homology 2 Domain
      pfam06367
      Location:230421
      Drf_FH3; Diaphanous FH3 Domain
      pfam06371
      Location:26227
      Drf_GBD; Diaphanous GTPase-binding Domain
    3. NM_011711.2NP_035841.1  formin-like protein 3 isoform 1

      See identical proteins and their annotated locations for NP_035841.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longest isoform (1).
      Source sequence(s)
      AC118646, AU042388, BC131961
      Consensus CDS
      CCDS27819.1
      UniProtKB/Swiss-Prot
      Q6ZPF4
      Related
      ENSMUSP00000085566.7, ENSMUST00000088233.13
      Conserved Domains (3) summary
      pfam02181
      Location:561926
      FH2; Formin Homology 2 Domain
      pfam06367
      Location:281472
      Drf_FH3; Diaphanous FH3 Domain
      pfam06371
      Location:26278
      Drf_GBD; Diaphanous GTPase-binding Domain

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000081.7 Reference GRCm39 C57BL/6J

      Range
      99215091..99268375 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006520844.5XP_006520907.1  formin-like protein 3 isoform X1

      Conserved Domains (3) summary
      pfam02181
      Location:510875
      FH2; Formin Homology 2 Domain
      pfam06367
      Location:230421
      Drf_FH3; Diaphanous FH3 Domain
      pfam06371
      Location:26227
      Drf_GBD; Diaphanous GTPase-binding Domain
    2. XM_030248512.2XP_030104372.1  formin-like protein 3 isoform X2

      Conserved Domains (3) summary
      pfam02181
      Location:327692
      FH2; Formin Homology 2 Domain
      pfam06367
      Location:47238
      Drf_FH3; Diaphanous FH3 Domain
      pfam06371
      Location:144
      Drf_GBD; Diaphanous GTPase-binding Domain
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