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    Fmnl3 formin-like 3 [ Mus musculus (house mouse) ]

    Gene ID: 22379, updated on 11-Nov-2018

    Summary

    Official Symbol
    Fmnl3provided by MGI
    Official Full Name
    formin-like 3provided by MGI
    Primary source
    MGI:MGI:109569
    See related
    Ensembl:ENSMUSG00000023008 Vega:OTTMUSG00000028048
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Wbp3; FBP11; mKIAA2014; 2700073B04Rik
    Expression
    Ubiquitous expression in lung adult (RPKM 22.2), ovary adult (RPKM 18.2) and 27 other tissues See more
    Orthologs

    Genomic context

    See Fmnl3 in Genome Data Viewer
    Location:
    15; 15 F1
    Exon count:
    28
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 15 NC_000081.6 (99317212..99370501, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 15 NC_000081.5 (99147653..99200897, complement)

    Chromosome 15 - NC_000081.6Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 1700120C14 gene Neighboring gene predicted gene, 34338 Neighboring gene predicted gene, 34447 Neighboring gene family with sequence similarity 186, member B Neighboring gene pre-mRNA processing factor 40B Neighboring gene transmembrane BAX inhibitor motif containing 6 Neighboring gene NCK-associated protein 5-like Neighboring gene NCK-associated protein 5-like, opposite strand

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (2) 

    Pathways from BioSystems

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    GTPase activating protein binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Rho GTPase binding IEA
    Inferred from Electronic Annotation
    more info
     
    actin binding IEA
    Inferred from Electronic Annotation
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    actin cytoskeleton organization IEA
    Inferred from Electronic Annotation
    more info
     
    angiogenesis IEA
    Inferred from Electronic Annotation
    more info
     
    cell migration ISO
    Inferred from Sequence Orthology
    more info
     
    cellular component organization IEA
    Inferred from Electronic Annotation
    more info
     
    cytoskeleton organization ISO
    Inferred from Sequence Orthology
    more info
     
    multicellular organism development IEA
    Inferred from Electronic Annotation
    more info
     
    regulation of cell shape ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    Golgi apparatus ISO
    Inferred from Sequence Orthology
    more info
     
    cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    intracellular membrane-bounded organelle ISO
    Inferred from Sequence Orthology
    more info
     
    membrane IEA
    Inferred from Electronic Annotation
    more info
     
    plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    formin-like protein 3
    Names
    WW domain binding protein 3
    formin-like 3 protein

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001310622.1NP_001297551.1  formin-like protein 3 isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks the penultimate exon compared to variant 1, which results in a frame-shift and a shorter isoform (2) with a distinct C-terminus compared to isoform 1.
      Source sequence(s)
      AC118646, AK163361, AU042388, BC131961
      Consensus CDS
      CCDS79409.1
      UniProtKB/Swiss-Prot
      Q6ZPF4
      UniProtKB/TrEMBL
      D3Z7A7
      Related
      ENSMUSP00000113094.1, OTTMUSP00000035279, ENSMUST00000120633.1, OTTMUST00000069462
      Conserved Domains (3) summary
      pfam02181
      Location:561926
      FH2; Formin Homology 2 Domain
      pfam06367
      Location:281472
      Drf_FH3; Diaphanous FH3 Domain
      pfam06371
      Location:26278
      Drf_GBD; Diaphanous GTPase-binding Domain
    2. NM_001310623.1NP_001297552.1  formin-like protein 3 isoform 3

      See identical proteins and their annotated locations for NP_001297552.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) lacks an in-frame coding exon in the mid region and the penultimate exon compared to variant 1. The resulting isoform (3) is shorter missing an internal protein segment and with a distinct C-terminus compared to isoform 1.
      Source sequence(s)
      AC118646, AU042388, BC131961
      Consensus CDS
      CCDS79408.1
      UniProtKB/Swiss-Prot
      Q6ZPF4
      Related
      ENSMUSP00000079984.7, OTTMUSP00000035278, ENSMUST00000081224.13, OTTMUST00000069461
      Conserved Domains (3) summary
      pfam02181
      Location:510875
      FH2; Formin Homology 2 Domain
      pfam06367
      Location:230421
      Drf_FH3; Diaphanous FH3 Domain
      pfam06371
      Location:26227
      Drf_GBD; Diaphanous GTPase-binding Domain
    3. NM_011711.2NP_035841.1  formin-like protein 3 isoform 1

      See identical proteins and their annotated locations for NP_035841.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longest isoform (1).
      Source sequence(s)
      AC118646, AU042388, BC131961
      Consensus CDS
      CCDS27819.1
      UniProtKB/Swiss-Prot
      Q6ZPF4
      Related
      ENSMUSP00000085566.6, OTTMUSP00000035277, ENSMUST00000088233.12, OTTMUST00000069460
      Conserved Domains (3) summary
      pfam02181
      Location:561926
      FH2; Formin Homology 2 Domain
      pfam06367
      Location:281472
      Drf_FH3; Diaphanous FH3 Domain
      pfam06371
      Location:26278
      Drf_GBD; Diaphanous GTPase-binding Domain

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000081.6 Reference GRCm38.p4 C57BL/6J

      Range
      99317212..99370501 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006520844.3XP_006520907.1  formin-like protein 3 isoform X1

      Conserved Domains (3) summary
      pfam02181
      Location:510875
      FH2; Formin Homology 2 Domain
      pfam06367
      Location:230421
      Drf_FH3; Diaphanous FH3 Domain
      pfam06371
      Location:26227
      Drf_GBD; Diaphanous GTPase-binding Domain
    2. XM_006520846.2XP_006520909.1  formin-like protein 3 isoform X2

      Conserved Domains (3) summary
      pfam02181
      Location:327692
      FH2; Formin Homology 2 Domain
      pfam06367
      Location:47238
      Drf_FH3; Diaphanous FH3 Domain
      pfam06371
      Location:144
      Drf_GBD; Diaphanous GTPase-binding Domain
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