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    Alg12 asparagine-linked glycosylation 12 (alpha-1,6-mannosyltransferase) [ Mus musculus (house mouse) ]

    Gene ID: 223774, updated on 31-Jan-2019

    Summary

    Official Symbol
    Alg12provided by MGI
    Official Full Name
    asparagine-linked glycosylation 12 (alpha-1,6-mannosyltransferase)provided by MGI
    Primary source
    MGI:MGI:2385025
    See related
    Ensembl:ENSMUSG00000035845
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    ECM39
    Expression
    Ubiquitous expression in ovary adult (RPKM 11.5), testis adult (RPKM 11.0) and 28 other tissues See more
    Orthologs

    Genomic context

    See Alg12 in Genome Data Viewer
    Location:
    15; 15 E3
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 15 NC_000081.6 (88805243..88819318, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 15 NC_000081.5 (88635673..88649748, complement)

    Chromosome 15 - NC_000081.6Genomic Context describing neighboring genes Neighboring gene predicted gene, 41377 Neighboring gene zinc finger, BED type containing 4 Neighboring gene cysteine-rich with EGF-like domains 2 Neighboring gene predicted gene, 33049 Neighboring gene proviral integration site 3

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Pathways from BioSystems

    General gene information

    Homology

    Clone Names

    • MGC29374

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    dol-P-Man:Man(7)GlcNAc(2)-PP-Dol alpha-1,6-mannosyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    dolichyl-pyrophosphate Man7GlcNAc2 alpha-1,6-mannosyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    mannosyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    mannosyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    transferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    transferase activity, transferring glycosyl groups IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    dolichol-linked oligosaccharide biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    protein N-linked glycosylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    Component Evidence Code Pubs
    endoplasmic reticulum IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    endoplasmic reticulum lumen IEA
    Inferred from Electronic Annotation
    more info
     
    integral component of membrane IEA
    Inferred from Electronic Annotation
    more info
     
    membrane IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    dol-P-Man:Man(7)GlcNAc(2)-PP-Dol alpha-1,6-mannosyltransferase
    Names
    asparagine-linked glycosylation 12 homolog (yeast, alpha-1,6-mannosyltransferase)
    asparagine-linked glycosylation protein 12 homolog
    dolichyl-P-Man:Man(7)GlcNAc(2)-PP-dolichyl-alpha-1,6-mannosyltransferase
    mannosyltransferase ALG12 homolog
    NP_001135829.1
    NP_663452.1
    XP_006520905.1

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001142357.1NP_001135829.1  dol-P-Man:Man(7)GlcNAc(2)-PP-Dol alpha-1,6-mannosyltransferase isoform 1

      See identical proteins and their annotated locations for NP_001135829.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AC117700, AK142322
      Consensus CDS
      CCDS49694.1
      UniProtKB/Swiss-Prot
      Q8VDB2
      Related
      ENSMUSP00000123935.1, ENSMUST00000162183.7
      Conserved Domains (1) summary
      cl21590
      Location:17405
      PMT_2; Dolichyl-phosphate-mannose-protein mannosyltransferase
    2. NM_145477.2NP_663452.1  dol-P-Man:Man(7)GlcNAc(2)-PP-Dol alpha-1,6-mannosyltransferase isoform 2

      See identical proteins and their annotated locations for NP_663452.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses an alternate splice site and lacks two exons in the central coding region, compared to variant 1. The encoded isoform (2) is shorter, compared to isoform 1.
      Source sequence(s)
      AC117700, AK142322
      Consensus CDS
      CCDS27732.1
      UniProtKB/Swiss-Prot
      Q8VDB2
      UniProtKB/TrEMBL
      Q8VCA2
      Related
      ENSMUSP00000043480.8, ENSMUST00000043087.14
      Conserved Domains (1) summary
      cl21590
      Location:17232
      PMT_2; Dolichyl-phosphate-mannose-protein mannosyltransferase

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000081.6 Reference GRCm38.p4 C57BL/6J

      Range
      88805243..88819318 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006520842.2XP_006520905.1  dol-P-Man:Man(7)GlcNAc(2)-PP-Dol alpha-1,6-mannosyltransferase isoform X1

      See identical proteins and their annotated locations for XP_006520905.1

      UniProtKB/Swiss-Prot
      Q8VDB2
      Conserved Domains (1) summary
      cl21590
      Location:17405
      PMT_2; Dolichyl-phosphate-mannose-protein mannosyltransferase
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