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    Brd1 bromodomain containing 1 [ Mus musculus (house mouse) ]

    Gene ID: 223770, updated on 19-Feb-2019

    Summary

    Official Symbol
    Brd1provided by MGI
    Official Full Name
    bromodomain containing 1provided by MGI
    Primary source
    MGI:MGI:1924161
    See related
    Ensembl:ENSMUSG00000022387
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    AI316859; mKIAA4191; 1110059H06Rik
    Expression
    Ubiquitous expression in CNS E11.5 (RPKM 7.6), CNS E14 (RPKM 5.9) and 28 other tissues See more
    Orthologs

    Genomic context

    See Brd1 in Genome Data Viewer
    Location:
    15; 15 E3
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 15 NC_000081.6 (88687034..88734226, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 15 NC_000081.5 (88517465..88564649, complement)

    Chromosome 15 - NC_000081.6Genomic Context describing neighboring genes Neighboring gene nuclear encoded tRNA methionine 4 (anticodon CAT) Neighboring gene predicted gene, 35997 Neighboring gene predicted gene, 41377 Neighboring gene zinc finger, BED type containing 4

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • KIAA4191, MGC164733

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    histone binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    histone H3 acetylation ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    MOZ/MORF histone acetyltransferase complex ISO
    Inferred from Sequence Orthology
    more info
     
    dendrite ISO
    Inferred from Sequence Orthology
    more info
     
    nuclear speck ISO
    Inferred from Sequence Orthology
    more info
     
    nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    perikaryon ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    bromodomain-containing protein 1

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001033274.3NP_001028446.2  bromodomain-containing protein 1

      Status: VALIDATED

      Source sequence(s)
      AK149714, AK220233, BB610711, BC037388, BC152356
      Consensus CDS
      CCDS27730.2
      UniProtKB/TrEMBL
      A7MCW6, E9PZ26, Q3UE68, Q571F6
      Related
      ENSMUSP00000105007.1, ENSMUST00000109381.8
      Conserved Domains (5) summary
      cd05839
      Location:10581173
      BR140_related; The PWWP domain is found in the BR140 family, which includes peregrin and BR140-like proteins 1 and 2. BR140 is the only family to contain the PWWP domain at the C terminus, with PHD and bromo domains in the N-terminal region. In myeloid leukemias, ...
      cd05512
      Location:566663
      Bromo_brd1_like; Bromodomain; brd1_like subfamily. BRD1 is a mammalian gene which encodes for a nuclear protein assumed to be a transcriptional regulator. BRD1 has been implicated with brain development and susceptibility to schizophrenia and bipolar affective disorder. ...
      cd15677
      Location:214267
      PHD_BRPF2; PHD finger found in bromodomain and PHD finger-containing protein 2 (BRPF2) and similar proteins
      cd15702
      Location:271388
      ePHD_BRPF2; Extended PHD finger found in bromodomain and PHD finger-containing protein 2 (BRPF2) and similar proteins
      pfam10513
      Location:47196
      EPL1; Enhancer of polycomb-like

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000081.6 Reference GRCm38.p4 C57BL/6J

      Range
      88687034..88734226 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006520835.2XP_006520898.1  bromodomain-containing protein 1 isoform X2

      See identical proteins and their annotated locations for XP_006520898.1

      UniProtKB/TrEMBL
      G5E8P1
      Related
      ENSMUSP00000105006.1, ENSMUST00000109380.7
      Conserved Domains (5) summary
      cd05839
      Location:9271042
      BR140_related; The PWWP domain is found in the BR140 family, which includes peregrin and BR140-like proteins 1 and 2. BR140 is the only family to contain the PWWP domain at the C terminus, with PHD and bromo domains in the N-terminal region. In myeloid leukemias, ...
      cd05512
      Location:566663
      Bromo_brd1_like; Bromodomain; brd1_like subfamily. BRD1 is a mammalian gene which encodes for a nuclear protein assumed to be a transcriptional regulator. BRD1 has been implicated with brain development and susceptibility to schizophrenia and bipolar affective disorder. ...
      cd15677
      Location:214267
      PHD_BRPF2; PHD finger found in bromodomain and PHD finger-containing protein 2 (BRPF2) and similar proteins
      cd15702
      Location:271388
      ePHD_BRPF2; Extended PHD finger found in bromodomain and PHD finger-containing protein 2 (BRPF2) and similar proteins
      pfam10513
      Location:47196
      EPL1; Enhancer of polycomb-like
    2. XM_006520834.2XP_006520897.1  bromodomain-containing protein 1 isoform X1

      Conserved Domains (5) summary
      cd05839
      Location:10281143
      BR140_related; The PWWP domain is found in the BR140 family, which includes peregrin and BR140-like proteins 1 and 2. BR140 is the only family to contain the PWWP domain at the C terminus, with PHD and bromo domains in the N-terminal region. In myeloid leukemias, ...
      cd15677
      Location:214267
      PHD_BRPF2; PHD finger found in bromodomain and PHD finger-containing protein 2 (BRPF2) and similar proteins
      cd15702
      Location:271388
      ePHD_BRPF2; Extended PHD finger found in bromodomain and PHD finger-containing protein 2 (BRPF2) and similar proteins
      pfam10513
      Location:47196
      EPL1; Enhancer of polycomb-like
      cl02556
      Location:566633
      Bromodomain; Bromodomain. Bromodomains are found in many chromatin-associated proteins and in nuclear histone acetyltransferases. They interact specifically with acetylated lysine.
    3. XM_006520836.2XP_006520899.1  bromodomain-containing protein 1 isoform X3

      Conserved Domains (5) summary
      cd05839
      Location:8921007
      BR140_related; The PWWP domain is found in the BR140 family, which includes peregrin and BR140-like proteins 1 and 2. BR140 is the only family to contain the PWWP domain at the C terminus, with PHD and bromo domains in the N-terminal region. In myeloid leukemias, ...
      cd05512
      Location:566663
      Bromo_brd1_like; Bromodomain; brd1_like subfamily. BRD1 is a mammalian gene which encodes for a nuclear protein assumed to be a transcriptional regulator. BRD1 has been implicated with brain development and susceptibility to schizophrenia and bipolar affective disorder. ...
      cd15677
      Location:214267
      PHD_BRPF2; PHD finger found in bromodomain and PHD finger-containing protein 2 (BRPF2) and similar proteins
      cd15702
      Location:271388
      ePHD_BRPF2; Extended PHD finger found in bromodomain and PHD finger-containing protein 2 (BRPF2) and similar proteins
      pfam10513
      Location:47196
      EPL1; Enhancer of polycomb-like
    4. XM_006520838.2XP_006520901.1  bromodomain-containing protein 1 isoform X5

      Conserved Domains (4) summary
      cd05512
      Location:566663
      Bromo_brd1_like; Bromodomain; brd1_like subfamily. BRD1 is a mammalian gene which encodes for a nuclear protein assumed to be a transcriptional regulator. BRD1 has been implicated with brain development and susceptibility to schizophrenia and bipolar affective disorder. ...
      cd15677
      Location:214267
      PHD_BRPF2; PHD finger found in bromodomain and PHD finger-containing protein 2 (BRPF2) and similar proteins
      cd15702
      Location:271388
      ePHD_BRPF2; Extended PHD finger found in bromodomain and PHD finger-containing protein 2 (BRPF2) and similar proteins
      pfam10513
      Location:47196
      EPL1; Enhancer of polycomb-like
    5. XM_006520837.2XP_006520900.1  bromodomain-containing protein 1 isoform X4

      Conserved Domains (4) summary
      cd05512
      Location:566663
      Bromo_brd1_like; Bromodomain; brd1_like subfamily. BRD1 is a mammalian gene which encodes for a nuclear protein assumed to be a transcriptional regulator. BRD1 has been implicated with brain development and susceptibility to schizophrenia and bipolar affective disorder. ...
      cd15677
      Location:214267
      PHD_BRPF2; PHD finger found in bromodomain and PHD finger-containing protein 2 (BRPF2) and similar proteins
      cd15702
      Location:271388
      ePHD_BRPF2; Extended PHD finger found in bromodomain and PHD finger-containing protein 2 (BRPF2) and similar proteins
      pfam10513
      Location:47196
      EPL1; Enhancer of polycomb-like

    RNA

    1. XR_384007.2 RNA Sequence

    2. XR_384008.2 RNA Sequence

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