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    Wars tryptophanyl-tRNA synthetase [ Mus musculus (house mouse) ]

    Gene ID: 22375, updated on 18-Nov-2018

    Summary

    Official Symbol
    Warsprovided by MGI
    Official Full Name
    tryptophanyl-tRNA synthetaseprovided by MGI
    Primary source
    MGI:MGI:104630
    See related
    Ensembl:ENSMUSG00000021266 Vega:OTTMUSG00000034952
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    WRS; TrpRS
    Expression
    Ubiquitous expression in genital fat pad adult (RPKM 173.4), colon adult (RPKM 54.6) and 26 other tissues See more
    Orthologs

    Genomic context

    See Wars in Genome Data Viewer
    Location:
    12; 12 F1
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 12 NC_000078.6 (108860030..108894174, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 12 NC_000078.5 (110098240..110132384, complement)

    Chromosome 12 - NC_000078.6Genomic Context describing neighboring genes Neighboring gene predicted gene, 33813 Neighboring gene microRNA 345 Neighboring gene solute carrier family 25, member 47 Neighboring gene WD repeat domain 25 Neighboring gene peptidyl prolyl isomerase H pseudogene Neighboring gene brain-enriched guanylate kinase-associated

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (2) 

    Pathways from BioSystems

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    aminoacyl-tRNA ligase activity IEA
    Inferred from Electronic Annotation
    more info
     
    kinase inhibitor activity ISO
    Inferred from Sequence Orthology
    more info
     
    ligase activity IEA
    Inferred from Electronic Annotation
    more info
     
    nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
     
    protein domain specific binding ISO
    Inferred from Sequence Orthology
    more info
     
    protein homodimerization activity ISO
    Inferred from Sequence Orthology
    more info
     
    protein kinase binding ISO
    Inferred from Sequence Orthology
    more info
     
    tryptophan-tRNA ligase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    tryptophan-tRNA ligase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    tryptophan-tRNA ligase activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    tryptophan-tRNA ligase activity ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    angiogenesis IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of protein kinase activity ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of protein phosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of gene expression ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of protein complex assembly ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of angiogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of protein ADP-ribosylation ISO
    Inferred from Sequence Orthology
    more info
     
    tRNA aminoacylation for protein translation IEA
    Inferred from Electronic Annotation
    more info
     
    translation IEA
    Inferred from Electronic Annotation
    more info
     
    tryptophanyl-tRNA aminoacylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    tryptophanyl-tRNA aminoacylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Component Evidence Code Pubs
    cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    protein-containing complex ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    tryptophan--tRNA ligase, cytoplasmic
    Names
    tryptophanyl-tRNA synthetase, cytoplasmic
    NP_001157786.1
    NP_001157960.1
    NP_035840.3
    XP_006515882.1

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001164314.1NP_001157786.1  tryptophan--tRNA ligase, cytoplasmic isoform 2

      See identical proteins and their annotated locations for NP_001157786.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR, 3' UTR, and coding region, compared to variant 1. The encoded isoform (2) has a shorter C-terminus compared to isoform 1. Variants 2 and 3 encode the same isoform (2).
      Source sequence(s)
      AC122811, AC152061, AK152966, BY773669
      Consensus CDS
      CCDS49171.1
      UniProtKB/Swiss-Prot
      P32921
      UniProtKB/TrEMBL
      Q3U6U7
      Related
      ENSMUSP00000105474.3, OTTMUSP00000048493, ENSMUST00000109848.9, OTTMUST00000088862
      Conserved Domains (3) summary
      PLN02486
      Location:89470
      PLN02486; aminoacyl-tRNA ligase
      TIGR00233
      Location:158467
      trpS; tryptophanyl-tRNA synthetase
      pfam00458
      Location:1668
      WHEP-TRS; WHEP-TRS domain
    2. NM_001164488.1NP_001157960.1  tryptophan--tRNA ligase, cytoplasmic isoform 2

      See identical proteins and their annotated locations for NP_001157960.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 3' UTR and 3' coding region, compared to variant 1. The encoded isoform (2) has a shorter C-terminus compared to isoform 1. Variants 2 and 3 encode the same isoform (2).
      Source sequence(s)
      AC152061, AK004541
      Consensus CDS
      CCDS49171.1
      UniProtKB/Swiss-Prot
      P32921
      UniProtKB/TrEMBL
      Q3U6U7
      Related
      ENSMUSP00000125320.1, OTTMUSP00000048495, ENSMUST00000161410.7, OTTMUST00000088864
      Conserved Domains (3) summary
      PLN02486
      Location:89470
      PLN02486; aminoacyl-tRNA ligase
      TIGR00233
      Location:158467
      trpS; tryptophanyl-tRNA synthetase
      pfam00458
      Location:1668
      WHEP-TRS; WHEP-TRS domain
    3. NM_011710.3NP_035840.3  tryptophan--tRNA ligase, cytoplasmic isoform 1

      See identical proteins and their annotated locations for NP_035840.3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longer isoform (1).
      Source sequence(s)
      AC122811, AC152061, CD563585, CF731228
      Consensus CDS
      CCDS26166.1
      UniProtKB/Swiss-Prot
      P32921
      Related
      ENSMUSP00000124625.1, OTTMUSP00000048496, ENSMUST00000161154.1, OTTMUST00000088865
      Conserved Domains (3) summary
      PLN02486
      Location:89470
      PLN02486; aminoacyl-tRNA ligase
      TIGR00233
      Location:158467
      trpS; tryptophanyl-tRNA synthetase
      pfam00458
      Location:1668
      WHEP-TRS; WHEP-TRS domain

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000078.6 Reference GRCm38.p4 C57BL/6J

      Range
      108860030..108894174 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006515819.1XP_006515882.1  tryptophan--tRNA ligase, cytoplasmic isoform X1

      See identical proteins and their annotated locations for XP_006515882.1

      UniProtKB/Swiss-Prot
      P32921
      Conserved Domains (3) summary
      PLN02486
      Location:89470
      PLN02486; aminoacyl-tRNA ligase
      TIGR00233
      Location:158467
      trpS; tryptophanyl-tRNA synthetase
      pfam00458
      Location:1668
      WHEP-TRS; WHEP-TRS domain
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