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    Wars tryptophanyl-tRNA synthetase [ Mus musculus (house mouse) ]

    Gene ID: 22375, updated on 23-Jun-2021

    Summary

    Official Symbol
    Warsprovided by MGI
    Official Full Name
    tryptophanyl-tRNA synthetaseprovided by MGI
    Primary source
    MGI:MGI:104630
    See related
    Ensembl:ENSMUSG00000021266
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    WRS; TrpRS; Wars1
    Expression
    Ubiquitous expression in genital fat pad adult (RPKM 173.4), colon adult (RPKM 54.6) and 26 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Wars in Genome Data Viewer
    Location:
    12; 12 F1
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 12 NC_000078.7 (108825956..108860100, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 12 NC_000078.6 (108860030..108894175, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 12 NC_000078.5 (110098240..110132384, complement)

    Chromosome 12 - NC_000078.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 53767 Neighboring gene microRNA 345 Neighboring gene solute carrier family 25, member 47 Neighboring gene predicted gene, 22079 Neighboring gene WD repeat domain 25 Neighboring gene peptidyl prolyl isomerase H pseudogene Neighboring gene brain-enriched guanylate kinase-associated Neighboring gene predicted gene, 52002

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Chemically induced (ENU) (1) 
    • Targeted (2) 

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables aminoacyl-tRNA ligase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables kinase inhibitor activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables ligase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein domain specific binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein homodimerization activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein kinase binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables tryptophan-tRNA ligase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables tryptophan-tRNA ligase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables tryptophan-tRNA ligase activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    enables tryptophan-tRNA ligase activity ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    part_of protein-containing complex ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    tryptophan--tRNA ligase, cytoplasmic
    Names
    tryptophanyl-tRNA synthetase, cytoplasmic
    NP_001157786.1
    NP_001157960.1
    NP_035840.3
    XP_006515882.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001164314.1NP_001157786.1  tryptophan--tRNA ligase, cytoplasmic isoform 2

      See identical proteins and their annotated locations for NP_001157786.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR, 3' UTR, and coding region, compared to variant 1. The encoded isoform (2) has a shorter C-terminus compared to isoform 1. Variants 2 and 3 encode the same isoform (2).
      Source sequence(s)
      AC122811, AC152061, AK152966, BY773669
      Consensus CDS
      CCDS49171.1
      UniProtKB/Swiss-Prot
      P32921
      UniProtKB/TrEMBL
      Q3U6U7
      Related
      ENSMUSP00000105474.4, ENSMUST00000109848.10
      Conserved Domains (3) summary
      PLN02486
      Location:89470
      PLN02486; aminoacyl-tRNA ligase
      TIGR00233
      Location:158467
      trpS; tryptophanyl-tRNA synthetase
      pfam00458
      Location:1668
      WHEP-TRS; WHEP-TRS domain
    2. NM_001164488.1NP_001157960.1  tryptophan--tRNA ligase, cytoplasmic isoform 2

      See identical proteins and their annotated locations for NP_001157960.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 3' UTR and 3' coding region, compared to variant 1. The encoded isoform (2) has a shorter C-terminus compared to isoform 1. Variants 2 and 3 encode the same isoform (2).
      Source sequence(s)
      AC152061, AK004541
      Consensus CDS
      CCDS49171.1
      UniProtKB/Swiss-Prot
      P32921
      UniProtKB/TrEMBL
      Q3U6U7
      Related
      ENSMUSP00000125320.2, ENSMUST00000161410.8
      Conserved Domains (3) summary
      PLN02486
      Location:89470
      PLN02486; aminoacyl-tRNA ligase
      TIGR00233
      Location:158467
      trpS; tryptophanyl-tRNA synthetase
      pfam00458
      Location:1668
      WHEP-TRS; WHEP-TRS domain
    3. NM_011710.3NP_035840.3  tryptophan--tRNA ligase, cytoplasmic isoform 1

      See identical proteins and their annotated locations for NP_035840.3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longer isoform (1).
      Source sequence(s)
      AC122811, AC152061, CD563585, CF731228
      Consensus CDS
      CCDS26166.1
      UniProtKB/Swiss-Prot
      P32921
      Related
      ENSMUSP00000124625.2, ENSMUST00000161154.2
      Conserved Domains (2) summary
      PLN02486
      Location:89470
      PLN02486; aminoacyl-tRNA ligase
      cd00936
      Location:1665
      WEPRS_RNA; WEPRS_RNA binding domain. This short RNA-binding domain is found in several higher eukaryote aminoacyl-tRNA synthetases (aaRSs). It is found in multiple copies in eukaryotic bifunctional glutamyl-prolyl-tRNA synthetases (EPRS) in a region that separates ...

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000078.7 Reference GRCm39 C57BL/6J

      Range
      108825956..108860100 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006515819.3XP_006515882.1  tryptophan--tRNA ligase, cytoplasmic isoform X1

      See identical proteins and their annotated locations for XP_006515882.1

      UniProtKB/Swiss-Prot
      P32921
      Conserved Domains (2) summary
      PLN02486
      Location:89470
      PLN02486; aminoacyl-tRNA ligase
      cd00936
      Location:1665
      WEPRS_RNA; WEPRS_RNA binding domain. This short RNA-binding domain is found in several higher eukaryote aminoacyl-tRNA synthetases (aaRSs). It is found in multiple copies in eukaryotic bifunctional glutamyl-prolyl-tRNA synthetases (EPRS) in a region that separates ...
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