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    Vtn vitronectin [ Mus musculus (house mouse) ]

    Gene ID: 22370, updated on 8-Dec-2018

    Summary

    Official Symbol
    Vtnprovided by MGI
    Official Full Name
    vitronectinprovided by MGI
    Primary source
    MGI:MGI:98940
    See related
    Ensembl:ENSMUSG00000017344
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Vn; AI256434
    Expression
    Biased expression in liver adult (RPKM 833.3), liver E18 (RPKM 554.4) and 2 other tissues See more
    Orthologs

    Genomic context

    See Vtn in Genome Data Viewer
    Location:
    11 B5; 11 46.74 cM
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 11 NC_000077.6 (78499120..78502325)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 11 NC_000077.5 (78312622..78315827)

    Chromosome 11 - NC_000077.6Genomic Context describing neighboring genes Neighboring gene solute carrier family 46, member 1 Neighboring gene sterile alpha and HEAT/Armadillo motif containing 1 Neighboring gene SEBOX homeobox Neighboring gene transmembrane protein 199

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from BioSystems

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    collagen binding ISO
    Inferred from Sequence Orthology
    more info
     
    extracellular matrix binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    extracellular matrix structural constituent HDA PubMed 
    heparin binding ISO
    Inferred from Sequence Orthology
    more info
     
    identical protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    integrin binding ISO
    Inferred from Sequence Orthology
    more info
     
    polysaccharide binding IEA
    Inferred from Electronic Annotation
    more info
     
    scavenger receptor activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    cell adhesion IEA
    Inferred from Electronic Annotation
    more info
     
    cell adhesion mediated by integrin ISO
    Inferred from Sequence Orthology
    more info
     
    cell migration ISO
    Inferred from Sequence Orthology
    more info
     
    cell proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    cell-matrix adhesion IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cell-matrix adhesion ISO
    Inferred from Sequence Orthology
    more info
     
    endodermal cell differentiation ISO
    Inferred from Sequence Orthology
    more info
     
    extracellular matrix organization IDA
    Inferred from Direct Assay
    more info
    PubMed 
    immune response IEA
    Inferred from Electronic Annotation
    more info
     
    liver regeneration ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of endopeptidase activity ISO
    Inferred from Sequence Orthology
    more info
     
    oligodendrocyte differentiation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of cell-substrate adhesion IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of peptidyl-tyrosine phosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of receptor-mediated endocytosis ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of smooth muscle cell migration ISO
    Inferred from Sequence Orthology
    more info
     
    protein polymerization ISO
    Inferred from Sequence Orthology
    more info
     
    smooth muscle cell-matrix adhesion ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    Golgi lumen ISO
    Inferred from Sequence Orthology
    more info
     
    basement membrane ISO
    Inferred from Sequence Orthology
    more info
     
    collagen-containing extracellular matrix HDA PubMed 
    collagen-containing extracellular matrix ISO
    Inferred from Sequence Orthology
    more info
     
    cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
     
    extracellular matrix IDA
    Inferred from Direct Assay
    more info
    PubMed 
    extracellular region IEA
    Inferred from Electronic Annotation
    more info
     
    extracellular space ISO
    Inferred from Sequence Orthology
    more info
     
    intracellular membrane-bounded organelle ISO
    Inferred from Sequence Orthology
    more info
     
    rough endoplasmic reticulum lumen ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    vitronectin
    Names
    S-protein
    serum-spreading factor

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_011707.2NP_035837.1  vitronectin precursor

      See identical proteins and their annotated locations for NP_035837.1

      Status: VALIDATED

      Source sequence(s)
      AI173462, AK090325, CK617609
      Consensus CDS
      CCDS25106.1
      UniProtKB/Swiss-Prot
      P29788
      Related
      ENSMUSP00000017488.4, ENSMUST00000017488.4
      Conserved Domains (2) summary
      smart00201
      Location:2062
      SO; Somatomedin B -like domains
      cd00094
      Location:153473
      HX; Hemopexin-like repeats.; Hemopexin is a heme-binding protein that transports heme to the liver. Hemopexin-like repeats occur in vitronectin and some matrix metalloproteinases family (matrixins). The HX repeats of some matrixins bind tissue inhibitor of ...

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000077.6 Reference GRCm38.p4 C57BL/6J

      Range
      78499120..78502325
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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