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    Eny2 ENY2 transcription and export complex 2 subunit [ Mus musculus (house mouse) ]

    Gene ID: 223527, updated on 30-Aug-2022

    Summary

    Official Symbol
    Eny2provided by MGI
    Official Full Name
    ENY2 transcription and export complex 2 subunitprovided by MGI
    Primary source
    MGI:MGI:1919286
    See related
    Ensembl:ENSMUSG00000022338 AllianceGenome:MGI:1919286
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    DC6; Ey2; 6720481I12; 1810057B09Rik
    Summary
    Predicted to enable chromatin binding activity and nuclear receptor coactivator activity. Predicted to be involved in several processes, including negative regulation of insulin secretion involved in cellular response to glucose stimulus; poly(A)+ mRNA export from nucleus; and regulation of transcription, DNA-templated. Predicted to act upstream of or within chromatin organization; mRNA transport; and protein transport. Predicted to be located in mitochondrion and nucleoplasm. Predicted to be part of nucleus. Is expressed in midbrain ventricular layer; neural retinal epithelium; olfactory cortex ventricular layer; and telencephalon ventricular layer. Orthologous to human ENY2 (ENY2 transcription and export complex 2 subunit). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Broad expression in CNS E11.5 (RPKM 20.8), CNS E14 (RPKM 20.3) and 23 other tissues See more
    Orthologs
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    Genomic context

    See Eny2 in Genome Data Viewer
    Location:
    15; 15 B3.2
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 15 NC_000081.7 (44291478..44301652)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 15 NC_000081.6 (44428082..44438256)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 15 NC_000081.5 (44259657..44269231)

    Chromosome 15 - NC_000081.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 24903 Neighboring gene predicted gene, 25093 Neighboring gene NudC domain containing 1 Neighboring gene predicted gene, 22392 Neighboring gene polycystic kidney and hepatic disease 1-like 1 Neighboring gene estrogen receptor-binding fragment-associated gene 9

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables chromatin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables nuclear receptor coactivator activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables transcription coactivator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables transcription coactivator activity ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    acts_upstream_of_or_within chromatin organization IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in histone H3 acetylation IC
    Inferred by Curator
    more info
    PubMed 
    involved_in histone H3 acetylation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in histone deubiquitination IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in histone deubiquitination ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in mRNA export from nucleus IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within mRNA transport IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in monoubiquitinated histone H2A deubiquitination ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in monoubiquitinated histone deubiquitination ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of insulin secretion involved in cellular response to glucose stimulus ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in poly(A)+ mRNA export from nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in poly(A)+ mRNA export from nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of DNA-templated transcription IC
    Inferred by Curator
    more info
    PubMed 
    involved_in positive regulation of DNA-templated transcription ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within protein transport IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in regulation of DNA repair IC
    Inferred by Curator
    more info
    PubMed 
    involved_in regulation of RNA splicing IC
    Inferred by Curator
    more info
    PubMed 
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    part_of DUBm complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    part_of DUBm complex ISO
    Inferred from Sequence Orthology
    more info
     
    part_of SAGA complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    part_of SAGA complex IC
    Inferred by Curator
    more info
    PubMed 
    part_of SAGA complex ISO
    Inferred from Sequence Orthology
    more info
     
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
     
    part_of nuclear pore IEA
    Inferred from Electronic Annotation
    more info
     
    part_of nuclear pore nuclear basket ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
     
    part_of transcription export complex 2 ISO
    Inferred from Sequence Orthology
    more info
     
    part_of transcription factor TFTC complex IC
    Inferred by Curator
    more info
    PubMed 

    General protein information

    Preferred Names
    transcription and mRNA export factor ENY2
    Names
    e(y)2 homolog
    e(y)2 protein
    enhancer of yellow 2 homolog
    enhancer of yellow 2 transcription factor homolog
    enhancer of yellow eye homolog

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_175009.3NP_778174.1  transcription and mRNA export factor ENY2

      See identical proteins and their annotated locations for NP_778174.1

      Status: PROVISIONAL

      Source sequence(s)
      AC127312
      Consensus CDS
      CCDS27456.1
      UniProtKB/Swiss-Prot
      Q9JIX0
      UniProtKB/TrEMBL
      A0A6P5R814, A0A8C6H3F1
      Related
      ENSMUSP00000052905.4, ENSMUST00000060652.5
      Conserved Domains (1) summary
      pfam10163
      Location:1694
      EnY2; Transcription factor e(y)2

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000081.7 Reference GRCm39 C57BL/6J

      Range
      44291478..44301652
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006520758.3XP_006520821.1  transcription and mRNA export factor ENY2 isoform X1

      See identical proteins and their annotated locations for XP_006520821.1

      UniProtKB/TrEMBL
      A0A2I3BRK6, A0A6P5R2U6
      Related
      ENSMUSP00000154515.2, ENSMUST00000226827.2
      Conserved Domains (1) summary
      pfam10163
      Location:1189
      EnY2; Transcription factor e(y)2