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    Marchf6 membrane associated ring-CH-type finger 6 [ Mus musculus (house mouse) ]

    Gene ID: 223455, updated on 23-Jun-2021

    Summary

    Official Symbol
    Marchf6provided by MGI
    Official Full Name
    membrane associated ring-CH-type finger 6provided by MGI
    Primary source
    MGI:MGI:2442773
    See related
    Ensembl:ENSMUSG00000039100
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Marc; March6; mKIAA0597; 3830408G03; F830029L24Rik
    Expression
    Ubiquitous expression in CNS E18 (RPKM 28.9), whole brain E14.5 (RPKM 26.6) and 28 other tissues See more
    Orthologs
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    Genomic context

    See Marchf6 in Genome Data Viewer
    Location:
    15; 15 B2
    Exon count:
    26
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 15 NC_000081.7 (31456045..31531670, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 15 NC_000081.6 (31455899..31531082, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 15 NC_000081.5 (31385654..31460792, complement)

    Chromosome 15 - NC_000081.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 41286 Neighboring gene ropporin 1-like Neighboring gene ubiquitin-conjugating enzyme E2 variant 2 pseudogene Neighboring gene predicted gene, 49208 Neighboring gene carboxymethylenebutenolidase-like (Pseudomonas) Neighboring gene chaperonin containing Tcp1, subunit 5 (epsilon)

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (2) 

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables enzyme binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables ubiquitin conjugating enzyme binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables ubiquitin protein ligase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables ubiquitin-protein transferase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables ubiquitin-specific protease binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    involved_in proteasomal protein catabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in proteasome-mediated ubiquitin-dependent protein catabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in protein K48-linked ubiquitination ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in protein ubiquitination ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in ubiquitin-dependent ERAD pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in integral component of endoplasmic reticulum membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in integral component of endoplasmic reticulum membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in integral component of membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    E3 ubiquitin-protein ligase MARCHF6
    Names
    E3 ubiquitin-protein ligase MARCH6
    MARCH-VI
    RING-type E3 ubiquitin transferase MARCH6
    RING-type E3 ubiquitin transferase MARCHF6
    membrane-associated RING finger protein 6
    membrane-associated RING-CH protein VI
    membrane-associated ring finger (C3HC4) 6
    NP_766194.2
    XP_011243653.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_172606.2NP_766194.2  E3 ubiquitin-protein ligase MARCHF6

      See identical proteins and their annotated locations for NP_766194.2

      Status: VALIDATED

      Source sequence(s)
      AC115735, AK042980, BU516606, CF182201, CF540592
      Consensus CDS
      CCDS37054.1
      UniProtKB/Swiss-Prot
      Q6ZQ89
      Related
      ENSMUSP00000087694.5, ENSMUST00000090227.6
      Conserved Domains (1) summary
      smart00744
      Location:856
      RINGv; The RING-variant domain is a C4HC3 zinc-finger like motif found in a number of cellular and viral proteins

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000081.7 Reference GRCm39 C57BL/6J

      Range
      31456045..31531670 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011245351.4XP_011243653.1  E3 ubiquitin-protein ligase MARCHF6 isoform X1

      Conserved Domains (1) summary
      cd16702
      Location:857
      RING_CH-C4HC3_MARCH6; RING-CH finger, H2 subclass (C4HC3-type), found in membrane-associated RING-CH6 (MARCH6)
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