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    Lin7c lin-7 homolog C (C. elegans) [ Mus musculus (house mouse) ]

    Gene ID: 22343, updated on 9-Sep-2018

    Summary

    Official Symbol
    Lin7cprovided by MGI
    Official Full Name
    lin-7 homolog C (C. elegans)provided by MGI
    Primary source
    MGI:MGI:1330839
    See related
    Ensembl:ENSMUSG00000027162 Vega:OTTMUSG00000015123
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Veli3; LIN-7C; MALS-3; LIN-7-C; AI303698; AU019331; AW125731; D2Ertd520e; 9130007B12Rik
    Expression
    Broad expression in CNS E18 (RPKM 9.9), whole brain E14.5 (RPKM 7.2) and 21 other tissues See more
    Orthologs

    Genomic context

    See Lin7c in Genome Data Viewer
    Location:
    2 E3; 2 56.65 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 2 NC_000068.7 (109890878..109900937)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 2 NC_000068.6 (109731035..109741094)

    Chromosome 2 - NC_000068.7Genomic Context describing neighboring genes Neighboring gene high mobility group box 2 pseudogene Neighboring gene predicted gene, 39907 Neighboring gene pluripotency associated transcript 8 Neighboring gene leucine-rich repeat-containing G protein-coupled receptor 4

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from BioSystems

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • MGC54626

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    L27 domain binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    L27 domain binding ISO
    Inferred from Sequence Orthology
    more info
     
    PDZ domain binding ISO
    Inferred from Sequence Orthology
    more info
     
    cytoskeletal protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein domain specific binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    exocytosis IEA
    Inferred from Electronic Annotation
    more info
     
    morphogenesis of an epithelial sheet ISO
    Inferred from Sequence Orthology
    more info
     
    neurotransmitter secretion IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    neurotransmitter secretion IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    protein localization to basolateral plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    protein transport IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    MPP7-DLG1-LIN7 complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    MPP7-DLG1-LIN7 complex ISO
    Inferred from Sequence Orthology
    more info
     
    basolateral plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    bicellular tight junction IEA
    Inferred from Electronic Annotation
    more info
     
    cell junction IEA
    Inferred from Electronic Annotation
    more info
     
    cell-cell junction IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    cell-cell junction ISO
    Inferred from Sequence Orthology
    more info
     
    cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    glutamatergic synapse ISO
    Inferred from Sequence Orthology
    more info
     
    membrane IEA
    Inferred from Electronic Annotation
    more info
     
    neuron projection IEA
    Inferred from Electronic Annotation
    more info
     
    plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    postsynaptic membrane IEA
    Inferred from Electronic Annotation
    more info
     
    synapse IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    synapse IDA
    Inferred from Direct Assay
    more info
    PubMed 
    synapse ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    protein lin-7 homolog C
    Names
    lin 7 homolog c
    mLin7C
    mammalian lin-seven protein 3
    veli-3
    vertebrate homolog of C. elegans Lin-7 type 3
    vertebrate lin-7 homolog 3

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_011699.3NP_035829.1  protein lin-7 homolog C

      See identical proteins and their annotated locations for NP_035829.1

      Status: PROVISIONAL

      Source sequence(s)
      AL845423
      Consensus CDS
      CCDS16509.1
      UniProtKB/Swiss-Prot
      O88952
      Related
      ENSMUSP00000028583.7, OTTMUSP00000016097, ENSMUST00000028583.7, OTTMUST00000035872
      Conserved Domains (2) summary
      cd00992
      Location:91172
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      pfam02828
      Location:1466
      L27; L27 domain

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000068.7 Reference GRCm38.p4 C57BL/6J

      Range
      109890878..109900937
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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