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    Lin7c lin-7 homolog C, crumbs cell polarity complex component [ Mus musculus (house mouse) ]

    Gene ID: 22343, updated on 22-Aug-2021

    Summary

    Official Symbol
    Lin7cprovided by MGI
    Official Full Name
    lin-7 homolog C, crumbs cell polarity complex componentprovided by MGI
    Primary source
    MGI:MGI:1330839
    See related
    Ensembl:ENSMUSG00000027162
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Li; Ve; LIN; MAL; LIN-; Veli3; LIN-7C; MALS-3; LIN-7-C; AI303698; AU019331; AW125731; D2Ertd520; D2Ertd520e; 9130007B12Rik
    Expression
    Broad expression in CNS E18 (RPKM 9.9), whole brain E14.5 (RPKM 7.2) and 21 other tissues See more
    Orthologs
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    Genomic context

    See Lin7c in Genome Data Viewer
    Location:
    2 E3; 2 56.65 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (109721223..109731282)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (109890878..109900937)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 2 NC_000068.6 (109731035..109741094)

    Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene high mobility group box 2 pseudogene Neighboring gene predicted gene, 54141 Neighboring gene pluripotency associated transcript 8 Neighboring gene leucine-rich repeat-containing G protein-coupled receptor 4

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • MGC54626

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables L27 domain binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables L27 domain binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables PDZ domain binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables cytoskeletal protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein domain specific binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    acts_upstream_of_or_within exocytosis IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in maintenance of epithelial cell apical/basal polarity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in morphogenesis of an epithelial sheet ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in neurotransmitter secretion IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    acts_upstream_of_or_within neurotransmitter secretion IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in protein localization to basolateral plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    acts_upstream_of_or_within protein transport IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    part_of MPP7-DLG1-LIN7 complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    part_of MPP7-DLG1-LIN7 complex ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in basolateral plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in bicellular tight junction IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cell junction IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in cell-cell junction IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in cell-cell junction ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in postsynaptic membrane IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in synapse IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in synapse IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in transport vesicle membrane TAS
    Traceable Author Statement
    more info
     

    General protein information

    Preferred Names
    protein lin-7 homolog C
    Names
    lin 7 homolog c
    lin-7 homolog C
    mLin7C
    mammalian lin-seven protein 3
    veli-3
    vertebrate homolog of C. elegans Lin-7 type 3
    vertebrate lin-7 homolog 3

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_011699.3NP_035829.1  protein lin-7 homolog C

      See identical proteins and their annotated locations for NP_035829.1

      Status: PROVISIONAL

      Source sequence(s)
      AL845423
      Consensus CDS
      CCDS16509.1
      UniProtKB/Swiss-Prot
      O88952
      Related
      ENSMUSP00000028583.8, ENSMUST00000028583.8
      Conserved Domains (2) summary
      cd00992
      Location:91172
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      pfam02828
      Location:1466
      L27; L27 domain

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000068.8 Reference GRCm39 C57BL/6J

      Range
      109721223..109731282
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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