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    Vdac3 voltage-dependent anion channel 3 [ Mus musculus (house mouse) ]

    Gene ID: 22335, updated on 8-Aug-2021

    Summary

    Official Symbol
    Vdac3provided by MGI
    Official Full Name
    voltage-dependent anion channel 3provided by MGI
    Primary source
    MGI:MGI:106922
    See related
    Ensembl:ENSMUSG00000008892
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Expression
    Ubiquitous expression in CNS E18 (RPKM 68.2), testis adult (RPKM 53.9) and 23 other tissues See more
    Orthologs
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    Genomic context

    See Vdac3 in Genome Data Viewer
    Location:
    8 A2; 8 11.42 cM
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (23067091..23083829, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (22577075..22593813, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 8 NC_000074.5 (23687573..23704230, complement)

    Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 39140 Neighboring gene small integral membrane protein 19 Neighboring gene solute carrier family 20, member 2 Neighboring gene predicted gene, 30086 Neighboring gene predicted gene, 30135

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (1)  1 citation
    • Endonuclease-mediated (1) 

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • MGC102096

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables porin activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables voltage-gated anion channel activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in integral component of membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in mitochondrial inner membrane HDA PubMed 
    is_active_in mitochondrial outer membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in mitochondrion HDA PubMed 
    located_in mitochondrion IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
     
    part_of pore complex IEA
    Inferred from Electronic Annotation
    more info
     
    located_in rough endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
     
    located_in synaptic vesicle ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    voltage-dependent anion-selective channel protein 3
    Names
    VDAC-3
    channel protein VDAC3
    mVDAC3
    mitochondrial outer membrane protein
    outer mitochondrial membrane protein porin 3

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001198998.1NP_001185927.1  voltage-dependent anion-selective channel protein 3 isoform 1

      See identical proteins and their annotated locations for NP_001185927.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AK002296, AK146957, BY103517
      UniProtKB/TrEMBL
      Q5EBQ0
      Conserved Domains (1) summary
      cd07306
      Location:5283
      Porin3_VDAC; Voltage-dependent anion channel of the outer mitochondrial membrane
    2. NM_011696.2NP_035826.1  voltage-dependent anion-selective channel protein 3 isoform 2

      See identical proteins and their annotated locations for NP_035826.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' coding region, compared to variant 1, and encodes an isoform (2) that is one amino acid shorter than isoform 1.
      Source sequence(s)
      AK002296, AK150741, BY103517
      Consensus CDS
      CCDS22179.1
      UniProtKB/Swiss-Prot
      Q60931
      UniProtKB/TrEMBL
      Q3TX38
      Related
      ENSMUSP00000009036.4, ENSMUST00000009036.11
      Conserved Domains (1) summary
      cd07306
      Location:5282
      Porin3_VDAC; Voltage-dependent anion channel of the outer mitochondrial membrane

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000074.7 Reference GRCm39 C57BL/6J

      Range
      23067091..23083829 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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