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    Stk24 serine/threonine kinase 24 [ Mus musculus (house mouse) ]

    Gene ID: 223255, updated on 31-Jan-2019

    Summary

    Official Symbol
    Stk24provided by MGI
    Official Full Name
    serine/threonine kinase 24provided by MGI
    Primary source
    MGI:MGI:2385007
    See related
    Ensembl:ENSMUSG00000063410
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Mst3; MST-3; STE20; C76483; 1810013H02Rik
    Expression
    Ubiquitous expression in bladder adult (RPKM 21.9), large intestine adult (RPKM 15.2) and 28 other tissues See more
    Orthologs

    Genomic context

    See Stk24 in Genome Data Viewer
    Location:
    14 E5; 14 64.95 cM
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 14 NC_000080.6 (121284187..121380006, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 14 NC_000080.5 (121685563..121778452, complement)

    Chromosome 14 - NC_000080.6Genomic Context describing neighboring genes Neighboring gene importin 5 Neighboring gene FERM, RhoGEF (Arhgef) and pleckstrin domain protein 1 (chondrocyte-derived) Neighboring gene RIKEN cDNA B930095G15 gene Neighboring gene predicted gene, 33299 Neighboring gene solute carrier family 15 (oligopeptide transporter), member 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Gene trapped (2) 

    Pathways from BioSystems

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • MGC6330

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
     
    protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    protein serine/threonine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    protein serine/threonine kinase activity ISO
    Inferred from Sequence Orthology
    more info
     
    transferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    MAPK cascade IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    activation of protein kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    apoptotic process IEA
    Inferred from Electronic Annotation
    more info
     
    cellular response to starvation ISO
    Inferred from Sequence Orthology
    more info
     
    execution phase of apoptosis ISO
    Inferred from Sequence Orthology
    more info
     
    intrinsic apoptotic signaling pathway in response to oxidative stress ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of cell migration ISO
    Inferred from Sequence Orthology
    more info
     
    neuron projection morphogenesis IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    phosphorylation IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of axon regeneration ISO
    Inferred from Sequence Orthology
    more info
     
    protein autophosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    protein phosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of axon regeneration ISO
    Inferred from Sequence Orthology
    more info
     
    response to hydrogen peroxide ISO
    Inferred from Sequence Orthology
    more info
     
    signal transduction by protein phosphorylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    stress-activated protein kinase signaling cascade IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    Component Evidence Code Pubs
    Golgi membrane ISO
    Inferred from Sequence Orthology
    more info
     
    cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    membrane IEA
    Inferred from Electronic Annotation
    more info
     
    nucleolus ISO
    Inferred from Sequence Orthology
    more info
     
    nucleus ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    serine/threonine-protein kinase 24
    Names
    STE20-like kinase MST3
    mammalian STE20-like protein kinase 3
    mammalian sterile twenty 3 kinase
    serine/threonine kinase 24 (STE20 homolog, yeast)
    NP_663440.1
    XP_006518981.1
    XP_011243345.1
    XP_017171477.1

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_145465.2NP_663440.1  serine/threonine-protein kinase 24

      See identical proteins and their annotated locations for NP_663440.1

      Status: VALIDATED

      Source sequence(s)
      AK154959, BE687884, BY730101
      Consensus CDS
      CCDS37016.1
      UniProtKB/Swiss-Prot
      Q99KH8
      UniProtKB/TrEMBL
      Q3U335
      Related
      ENSMUSP00000078746.7, ENSMUST00000079817.7
      Conserved Domains (2) summary
      smart00220
      Location:24274
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd06609
      Location:22295
      STKc_MST3_like; Catalytic domain of Mammalian Ste20-like protein kinase 3-like Serine/Threonine Kinases

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000080.6 Reference GRCm38.p4 C57BL/6J

      Range
      121284187..121380006 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006518918.1XP_006518981.1  serine/threonine-protein kinase 24 isoform X3

      Conserved Domains (2) summary
      smart00220
      Location:1176
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cl21453
      Location:1197
      PKc_like; Protein Kinases, catalytic domain
    2. XM_011245043.2XP_011243345.1  serine/threonine-protein kinase 24 isoform X2

      Conserved Domains (2) summary
      smart00220
      Location:23273
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd06609
      Location:21294
      STKc_MST3_like; Catalytic domain of Mammalian Ste20-like protein kinase 3-like Serine/Threonine Kinases
    3. XM_017315988.1XP_017171477.1  serine/threonine-protein kinase 24 isoform X1

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