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    Farp1 FERM, RhoGEF (Arhgef) and pleckstrin domain protein 1 (chondrocyte-derived) [ Mus musculus (house mouse) ]

    Gene ID: 223254, updated on 9-Sep-2018

    Summary

    Official Symbol
    Farp1provided by MGI
    Official Full Name
    FERM, RhoGEF (Arhgef) and pleckstrin domain protein 1 (chondrocyte-derived)provided by MGI
    Primary source
    MGI:MGI:2446173
    See related
    Ensembl:ENSMUSG00000025555 Vega:OTTMUSG00000026446
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Cdep; AW228844; BC030329
    Expression
    Ubiquitous expression in limb E14.5 (RPKM 25.3), CNS E18 (RPKM 22.0) and 27 other tissues See more
    Orthologs

    Genomic context

    See Farp1 in Genome Data Viewer
    Location:
    14; 14 E5
    Exon count:
    28
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 14 NC_000080.6 (121035200..121283744)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 14 NC_000080.5 (121434796..121682948)

    Chromosome 14 - NC_000080.6Genomic Context describing neighboring genes Neighboring gene predicted gene, 33173 Neighboring gene importin 5 Neighboring gene RIKEN cDNA B930095G15 gene Neighboring gene serine/threonine kinase 24 Neighboring gene predicted gene, 33299

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (2) 

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    Rac GTPase binding ISO
    Inferred from Sequence Orthology
    more info
     
    Rac guanyl-nucleotide exchange factor activity ISO
    Inferred from Sequence Orthology
    more info
     
    Rho guanyl-nucleotide exchange factor activity IEA
    Inferred from Electronic Annotation
    more info
     
    cytoskeletal protein binding IEA
    Inferred from Electronic Annotation
    more info
     
    guanyl-nucleotide exchange factor activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    dendrite morphogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    multicellular organism development IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of phosphatase activity ISO
    Inferred from Sequence Orthology
    more info
     
    postsynaptic actin cytoskeleton organization ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of Rho protein signal transduction IEA
    Inferred from Electronic Annotation
    more info
     
    regulation of presynapse assembly ISO
    Inferred from Sequence Orthology
    more info
     
    retrograde trans-synaptic signaling by trans-synaptic protein complex ISO
    Inferred from Sequence Orthology
    more info
     
    synapse assembly ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    cell junction IEA
    Inferred from Electronic Annotation
    more info
     
    cell projection IEA
    Inferred from Electronic Annotation
    more info
     
    cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
     
    cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    dendrite ISO
    Inferred from Sequence Orthology
    more info
     
    extrinsic component of cytoplasmic side of plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    extrinsic component of postsynaptic membrane ISO
    Inferred from Sequence Orthology
    more info
     
    glutamatergic synapse ISO
    Inferred from Sequence Orthology
    more info
     
    membrane IEA
    Inferred from Electronic Annotation
    more info
     
    neuron projection IEA
    Inferred from Electronic Annotation
    more info
     
    plasma membrane IEA
    Inferred from Electronic Annotation
    more info
     
    synapse IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    FERM, ARHGEF and pleckstrin domain-containing protein 1; FERM, RhoGEF and pleckstrin domain-containing protein 1
    Names
    FERMRhoGEF (Arhgef) and pleckstrin domain protein 1

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_134082.3NP_598843.3  FERM, ARHGEF and pleckstrin domain-containing protein 1

      See identical proteins and their annotated locations for NP_598843.3

      Status: VALIDATED

      Source sequence(s)
      AK034903, BB840008, CF537427, CK389990, CN456176, CN535003, DV655111
      Consensus CDS
      CCDS37015.1
      UniProtKB/Swiss-Prot
      F8VPU2
      UniProtKB/TrEMBL
      Q8BM51
      Related
      ENSMUSP00000026635.6, OTTMUSP00000032599, ENSMUST00000026635.7, OTTMUST00000065407
      Conserved Domains (9) summary
      smart00295
      Location:41230
      B41; Band 4.1 homologues
      cd00160
      Location:544731
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
      cd01220
      Location:756864
      PH1_FARP1-like; FERM, RhoGEF and pleckstrin domain-containing protein 1 and related proteins Pleckstrin Homology (PH) domain, repeat 1
      cd13193
      Location:217337
      FERM_C_FARP1-like; FERM domain C-lobe of FERM, RhoGEF and pleckstrin domain-containing protein 1 and related proteins
      cd13235
      Location:9341031
      PH2_FARP1-like; FERM, RhoGEF and pleckstrin domain-containing protein 1 and related proteins Pleckstrin Homology (PH) domain, repeat 2
      pfam00169
      Location:9391032
      PH; PH domain
      pfam00373
      Location:127230
      FERM_M; FERM central domain
      pfam08736
      Location:329371
      FA; FERM adjacent (FA)
      pfam09379
      Location:44107
      FERM_N; FERM N-terminal domain

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000080.6 Reference GRCm38.p4 C57BL/6J

      Range
      121035200..121283744
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006518914.3XP_006518977.1  FERM, RhoGEF and pleckstrin domain-containing protein 1 isoform X1

      See identical proteins and their annotated locations for XP_006518977.1

      UniProtKB/Swiss-Prot
      F8VPU2
      Conserved Domains (9) summary
      smart00295
      Location:41230
      B41; Band 4.1 homologues
      cd00160
      Location:544731
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
      cd01220
      Location:756864
      PH1_FARP1-like; FERM, RhoGEF and pleckstrin domain-containing protein 1 and related proteins Pleckstrin Homology (PH) domain, repeat 1
      cd13193
      Location:217337
      FERM_C_FARP1-like; FERM domain C-lobe of FERM, RhoGEF and pleckstrin domain-containing protein 1 and related proteins
      cd13235
      Location:9341031
      PH2_FARP1-like; FERM, RhoGEF and pleckstrin domain-containing protein 1 and related proteins Pleckstrin Homology (PH) domain, repeat 2
      pfam00169
      Location:9391032
      PH; PH domain
      pfam00373
      Location:127230
      FERM_M; FERM central domain
      pfam08736
      Location:329371
      FA; FERM adjacent (FA)
      pfam09379
      Location:44107
      FERM_N; FERM N-terminal domain
    2. XM_006518915.2XP_006518978.1  FERM, RhoGEF and pleckstrin domain-containing protein 1 isoform X2

      Conserved Domains (9) summary
      smart00295
      Location:41230
      B41; Band 4.1 homologues
      cd00160
      Location:534721
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
      cd01220
      Location:746854
      PH1_FARP1-like; FERM, RhoGEF and pleckstrin domain-containing protein 1 and related proteins Pleckstrin Homology (PH) domain, repeat 1
      cd13193
      Location:217337
      FERM_C_FARP1-like; FERM domain C-lobe of FERM, RhoGEF and pleckstrin domain-containing protein 1 and related proteins
      cd13235
      Location:9241021
      PH2_FARP1-like; FERM, RhoGEF and pleckstrin domain-containing protein 1 and related proteins Pleckstrin Homology (PH) domain, repeat 2
      pfam00169
      Location:9291022
      PH; PH domain
      pfam00373
      Location:127230
      FERM_M; FERM central domain
      pfam08736
      Location:329371
      FA; FERM adjacent (FA)
      pfam09379
      Location:44107
      FERM_N; FERM N-terminal domain
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