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    Vasp vasodilator-stimulated phosphoprotein [ Mus musculus (house mouse) ]

    Gene ID: 22323, updated on 8-Aug-2021

    Summary

    Official Symbol
    Vaspprovided by MGI
    Official Full Name
    vasodilator-stimulated phosphoproteinprovided by MGI
    Primary source
    MGI:MGI:109268
    See related
    Ensembl:ENSMUSG00000030403
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Expression
    Broad expression in colon adult (RPKM 234.9), duodenum adult (RPKM 170.7) and 24 other tissues See more
    Orthologs
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    Genomic context

    See Vasp in Genome Data Viewer
    Location:
    7; 7 A3
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (18990854..19005779, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (19256929..19271854, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 7 NC_000073.5 (19842278..19857203, complement)

    Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene optic atrophy 3 Neighboring gene predicted gene, 25134 Neighboring gene predicted gene, 38499 Neighboring gene protein phosphatase, Mg2+/Mn2+ dependent, 1N (putative) Neighboring gene reticulon 2 (Z-band associated protein)

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables SH3 domain binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables actin binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables profilin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables profilin binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in actin cytoskeleton organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    acts_upstream_of_or_within actin cytoskeleton organization IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in actin polymerization or depolymerization IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in axon guidance IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    acts_upstream_of_or_within axon guidance IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in neural tube closure IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    acts_upstream_of_or_within neural tube closure IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in positive regulation of actin filament polymerization IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in positive regulation of actin filament polymerization ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in protein homotetramerization IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    located_in bicellular tight junction IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cell junction IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cell projection IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytosol TAS
    Traceable Author Statement
    more info
     
    located_in filopodium IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in focal adhesion IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in focal adhesion ISO
    Inferred from Sequence Orthology
    more info
     
    located_in lamellipodium IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    vasodilator-stimulated phosphoprotein

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001282021.1NP_001268950.1  vasodilator-stimulated phosphoprotein isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses an alternate in-frame splice site in the central coding region, compared to variant 1. The encoded isoform (2) is shorter, compared to isoform 1.
      Source sequence(s)
      AK140329, BB850928, CO040918
      UniProtKB/Swiss-Prot
      P70460
      Conserved Domains (2) summary
      cd01207
      Location:5113
      EVH1_Ena_VASP-like; Enabled/VASP family EVH1 domain
      pfam08776
      Location:336370
      VASP_tetra; VASP tetramerization domain
    2. NM_001282022.1NP_001268951.1  vasodilator-stimulated phosphoprotein isoform 3

      See identical proteins and their annotated locations for NP_001268951.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) uses an alternate in-frame splice site in the central coding region, compared to variant 1. The encoded isoform (3) is shorter, compared to isoform 1.
      Source sequence(s)
      AK140329, BB850928, CO040918
      UniProtKB/Swiss-Prot
      P70460
      Conserved Domains (3) summary
      cd01207
      Location:5104
      EVH1_Ena_VASP-like; Enabled/VASP family EVH1 domain
      pfam08687
      Location:235350
      ASD2; Apx/Shroom domain ASD2
      pfam08776
      Location:327361
      VASP_tetra; VASP tetramerization domain
    3. NM_009499.3NP_033525.2  vasodilator-stimulated phosphoprotein isoform 1

      See identical proteins and their annotated locations for NP_033525.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
      Source sequence(s)
      AK140329, BB850928, CO040918
      Consensus CDS
      CCDS52056.1
      UniProtKB/Swiss-Prot
      P70460
      Related
      ENSMUSP00000032561.9, ENSMUST00000032561.9
      Conserved Domains (2) summary
      cd01207
      Location:5113
      EVH1_Ena_VASP-like; Enabled/VASP family EVH1 domain
      pfam08776
      Location:337371
      VASP_tetra; VASP tetramerization domain

    RNA

    1. NR_104069.1 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) lacks two internal exons, and uses two alternate splice sites in internal exons, compared to variant 1. This variant is represented as non-coding because it lacks a significant portion of the coding region and does not encode a supported protein.
      Source sequence(s)
      AK140329, BB850928, CO040918

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000073.7 Reference GRCm39 C57BL/6J

      Range
      18990854..19005779 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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