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    Sox21 SRY (sex determining region Y)-box 21 [ Mus musculus (house mouse) ]

    Gene ID: 223227, updated on 9-Dec-2024

    Summary

    Official Symbol
    Sox21provided by MGI
    Official Full Name
    SRY (sex determining region Y)-box 21provided by MGI
    Primary source
    MGI:MGI:2654070
    See related
    Ensembl:ENSMUSG00000061517 AllianceGenome:MGI:2654070
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Sox25
    Summary
    Enables DNA-binding transcription activator activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in positive regulation of transcription by RNA polymerase II. Acts upstream of or within hair follicle development and regulation of DNA-templated transcription. Predicted to be active in nucleus. Is expressed in several structures, including alimentary system; central nervous system; early conceptus; placenta; and skin. Orthologous to human SOX21 (SRY-box transcription factor 21). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
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    Genomic context

    See Sox21 in Genome Data Viewer
    Location:
    14 E4; 14 61.92 cM
    Exon count:
    1
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 14 NC_000080.7 (118470645..118474442, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 14 NC_000080.6 (118233233..118237030, complement)

    Chromosome 14 - NC_000080.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 4933431J24 gene Neighboring gene predicted gene, 31981 Neighboring gene predicted gene, 32045 Neighboring gene STARR-seq mESC enhancer starr_37639 Neighboring gene SRY (sex determining region Y)-box 21, opposite strand 1 Neighboring gene microRNA 6241 Neighboring gene predicted gene 9376

    Genomic regions, transcripts, and products

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 
    • Targeted (1)  1 citation

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Component Evidence Code Pubs
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in nucleus IC
    Inferred by Curator
    more info
    PubMed 

    General protein information

    Preferred Names
    transcription factor SOX-21
    Names
    DNA-binding protein SOX21
    HMG-box protein SOX21
    SRY-box containing gene 21

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_177753.3NP_808421.1  transcription factor SOX-21

      See identical proteins and their annotated locations for NP_808421.1

      Status: VALIDATED

      Source sequence(s)
      CT025686
      Consensus CDS
      CCDS27334.1
      UniProtKB/Swiss-Prot
      B9EJU0, Q811W0, Q8VH35
      Related
      ENSMUSP00000127396.2, ENSMUST00000170662.2
      Conserved Domains (2) summary
      cd01388
      Location:778
      SOX-TCF_HMG-box; class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and vertebrates, and ...
      pfam12336
      Location:7795
      SOXp; SOX transcription factor

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000080.7 Reference GRCm39 C57BL/6J

      Range
      118470645..118474442 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)