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    Urod uroporphyrinogen decarboxylase [ Mus musculus (house mouse) ]

    Gene ID: 22275, updated on 23-May-2018

    Summary

    Official Symbol
    Urodprovided by MGI
    Official Full Name
    uroporphyrinogen decarboxylaseprovided by MGI
    Primary source
    MGI:MGI:98916
    See related
    Ensembl:ENSMUSG00000028684 Vega:OTTMUSG00000009782
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    UPD; Uro-d; AI323803
    Summary
    This gene encodes an enzyme that catalyzes the conversion of uroporphyrinogen-III to coproporphyrinogen-III, an intermediate step in heme biosynthesis. Homozygous knockout mice for this gene exhibit embryonic lethality. [provided by RefSeq, Aug 2015]
    Expression
    Broad expression in liver E14.5 (RPKM 225.2), liver E14 (RPKM 197.6) and 23 other tissues See more
    Orthologs

    Genomic context

    See Urod in Genome Data Viewer
    Location:
    4 D1; 4 53.41 cM
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 4 NC_000070.6 (116989965..116994436, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 4 NC_000070.5 (116662822..116666980, complement)

    Chromosome 4 - NC_000070.6Genomic Context describing neighboring genes Neighboring gene ribosomal protein L36, pseudogene 8 Neighboring gene zinc finger SWIM-type containing 5 Neighboring gene general transcription factor IIB pseudogene Neighboring gene HECT domain E3 ubiquitin protein ligase 3 Neighboring gene tetraspanin 17 pseudogene

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    Related articles in PubMed

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from BioSystems

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    carboxy-lyase activity IEA
    Inferred from Electronic Annotation
    more info
     
    ferrous iron binding ISO
    Inferred from Sequence Orthology
    more info
     
    lyase activity IEA
    Inferred from Electronic Annotation
    more info
     
    uroporphyrinogen decarboxylase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    uroporphyrinogen decarboxylase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    uroporphyrinogen decarboxylase activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    uroporphyrinogen decarboxylase activity ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    heme biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    heme biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    heme metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    porphyrin-containing compound biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
     
    uroporphyrinogen III metabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    cytosol IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    uroporphyrinogen decarboxylase
    NP_033504.2
    XP_006502994.1
    XP_006502995.1

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_009478.4NP_033504.2  uroporphyrinogen decarboxylase

      See identical proteins and their annotated locations for NP_033504.2

      Status: REVIEWED

      Source sequence(s)
      AK002844, AK007470, AL671671, BY266170
      Consensus CDS
      CCDS18521.1
      UniProtKB/Swiss-Prot
      P70697
      Related
      ENSMUSP00000030446.8, OTTMUSP00000010340, ENSMUST00000030446.14, OTTMUST00000022649
      Conserved Domains (1) summary
      cd00717
      Location:20359
      URO-D; Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction ...

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000070.6 Reference GRCm38.p4 C57BL/6J

      Range
      116989965..116994436 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006502931.2XP_006502994.1  uroporphyrinogen decarboxylase isoform X1

      Conserved Domains (1) summary
      cd00717
      Location:20338
      URO-D; Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction ...
    2. XM_006502932.2XP_006502995.1  uroporphyrinogen decarboxylase isoform X2

      Conserved Domains (1) summary
      cd00717
      Location:20305
      URO-D; Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction ...
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