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    Usp4 ubiquitin specific peptidase 4 (proto-oncogene) [ Mus musculus (house mouse) ]

    Gene ID: 22258, updated on 16-Aug-2021

    Summary

    Official Symbol
    Usp4provided by MGI
    Official Full Name
    ubiquitin specific peptidase 4 (proto-oncogene)provided by MGI
    Primary source
    MGI:MGI:98905
    See related
    Ensembl:ENSMUSG00000032612
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    U; Unp; mKIAA4155; F730026I20Rik
    Expression
    Ubiquitous expression in testis adult (RPKM 35.9), CNS E11.5 (RPKM 25.1) and 28 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Usp4 in Genome Data Viewer
    Location:
    9 F2; 9 59.25 cM
    Exon count:
    22
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (108223763..108269744)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (108346564..108392545)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 9 NC_000075.5 (108250162..108294860)

    Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene ras homolog family member A Neighboring gene glutathione peroxidase 1 Neighboring gene ribosomal protein S2, pseudogene 11 Neighboring gene RIKEN cDNA 1700102P08 gene Neighboring gene interactor of HORMAD1 1 Neighboring gene predicted gene, 25456

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • KIAA4155

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables adenosine receptor binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables cysteine-type peptidase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables peptidase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables thiol-dependent deubiquitinase ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    involved_in negative regulation of protein ubiquitination ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in protein deubiquitination ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in protein localization to cell surface ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within proteolysis IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in regulation of protein stability ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in spliceosomal tri-snRNP complex assembly ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in ubiquitin-dependent protein catabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    ubiquitin carboxyl-terminal hydrolase 4
    Names
    deubiquitinating enzyme 4
    ubiquitin specific protease 4 (proto-oncogene)
    ubiquitin thioesterase 4
    ubiquitin thiolesterase 4
    ubiquitin-specific-processing protease 4
    ubiquitous nuclear protein
    NP_001298086.1
    NP_035808.2
    XP_006511759.1
    XP_006511760.1
    XP_006511762.1
    XP_006511763.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001311157.1NP_001298086.1  ubiquitin carboxyl-terminal hydrolase 4 isoform 2

      See identical proteins and their annotated locations for NP_001298086.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an alternate in-frame exon in the 5' coding region compared to variant 1. It encodes isoform 2, which is shorter than isoform 1.
      Source sequence(s)
      AC161260, AK164245, AK187607, AK199674, BB770947, BE982062, BY322979, CA548182, CK624008
      Consensus CDS
      CCDS81074.1
      UniProtKB/TrEMBL
      A0A0A6YW28, Q3TPN5
      Related
      ENSMUSP00000141368.2, ENSMUST00000194959.6
      Conserved Domains (6) summary
      smart00695
      Location:27125
      DUSP; Domain in ubiquitin-specific proteases
      COG5560
      Location:35875
      UBP12; Ubiquitin C-terminal hydrolase [Posttranslational modification, protein turnover, chaperones]
      cd02674
      Location:728873
      Peptidase_C19R; A subfamily of peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...
      cl02553
      Location:255439
      Peptidase_C19; Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyse bonds involving the carboxyl group of the C-terminal Gly ...
      pfam14533
      Location:457520
      USP7_C2; Ubiquitin-specific protease C-terminal
      pfam14836
      Location:139226
      Ubiquitin_3; Ubiquitin-like domain
    2. NM_011678.2NP_035808.2  ubiquitin carboxyl-terminal hydrolase 4 isoform 1

      See identical proteins and their annotated locations for NP_035808.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AK149964, BY322979, CD741063
      Consensus CDS
      CCDS23523.1
      UniProtKB/Swiss-Prot
      P35123
      Related
      ENSMUSP00000035237.7, ENSMUST00000035237.12
      Conserved Domains (6) summary
      smart00695
      Location:27125
      DUSP; Domain in ubiquitin-specific proteases
      COG5560
      Location:35922
      UBP12; Ubiquitin C-terminal hydrolase [Posttranslational modification, protein turnover, chaperones]
      cd02674
      Location:775920
      Peptidase_C19R; A subfamily of peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...
      cl02553
      Location:302486
      Peptidase_C19; Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyse bonds involving the carboxyl group of the C-terminal Gly ...
      pfam14533
      Location:504567
      USP7_C2; Ubiquitin-specific protease C-terminal
      pfam14836
      Location:139226
      Ubiquitin_3; Ubiquitin-like domain

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000075.7 Reference GRCm39 C57BL/6J

      Range
      108223763..108269744
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006511696.2XP_006511759.1  ubiquitin carboxyl-terminal hydrolase 4 isoform X1

      Conserved Domains (1) summary
      COG5560
      Location:35927
      UBP12; Ubiquitin C-terminal hydrolase [Posttranslational modification, protein turnover, chaperones]
    2. XM_006511699.4XP_006511762.1  ubiquitin carboxyl-terminal hydrolase 4 isoform X3

      Conserved Domains (1) summary
      COG5560
      Location:35850
      UBP12; Ubiquitin C-terminal hydrolase [Posttranslational modification, protein turnover, chaperones]
    3. XM_006511700.3XP_006511763.1  ubiquitin carboxyl-terminal hydrolase 4 isoform X4

      Related
      ENSMUSP00000141321.2, ENSMUST00000194224.6
      Conserved Domains (1) summary
      COG5560
      Location:35845
      UBP12; Ubiquitin C-terminal hydrolase [Posttranslational modification, protein turnover, chaperones]
    4. XM_006511697.2XP_006511760.1  ubiquitin carboxyl-terminal hydrolase 4 isoform X2

      Conserved Domains (1) summary
      COG5560
      Location:35880
      UBP12; Ubiquitin C-terminal hydrolase [Posttranslational modification, protein turnover, chaperones]
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