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    HS3ST5 heparan sulfate-glucosamine 3-sulfotransferase 5 [ Homo sapiens (human) ]

    Gene ID: 222537, updated on 17-Jun-2024

    Summary

    Official Symbol
    HS3ST5provided by HGNC
    Official Full Name
    heparan sulfate-glucosamine 3-sulfotransferase 5provided by HGNC
    Primary source
    HGNC:HGNC:19419
    See related
    Ensembl:ENSG00000249853 MIM:609407; AllianceGenome:HGNC:19419
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    3OST5; 3-OST-5; HS3OST5; NBLA04021
    Summary
    HS3ST5 belongs to a group of heparan sulfate 3-O-sulfotransferases (EC 2.8.2.23) that transfer sulfate from 3-prime-phosphoadenosine 5-prime phosphosulfate (PAPS) to heparan sulfate and heparin (Mochizuki et al., 2003 [PubMed 12740361]).[supplied by OMIM, Mar 2008]
    Expression
    Low expression observed in reference dataset See more
    Orthologs
    NEW
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    Genomic context

    See HS3ST5 in Genome Data Viewer
    Location:
    6q21-q22.1
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 6 NC_000006.12 (114055596..114343023, complement)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 6 NC_060930.1 (115238715..115526173, complement)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (114376760..114664187, complement)

    Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC124901384 Neighboring gene HDAC2 and HS3ST5 antisense RNA 2 Neighboring gene Sharpr-MPRA regulatory region 9060 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr6:114317472-114318671 Neighboring gene NUDT19 pseudogene 3 Neighboring gene ribosomal protein SA pseudogene 43 Neighboring gene uncharacterized LOC124901383 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr6:114524453-114524954 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr6:114524955-114525454 Neighboring gene RNA, 5S ribosomal pseudogene 213 Neighboring gene NANOG hESC enhancer GRCh37_chr6:114603304-114603805 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr6:114640738-114641477 Neighboring gene uncharacterized LOC107986638 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr6:114683371-114683962 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr6:114683963-114684552 Neighboring gene DnaJ heat shock protein family (Hsp40) member A1 pseudogene 4 Neighboring gene Sharpr-MPRA regulatory region 3090 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr6:114742086-114742751 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr6:114743417-114744081 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr6:114745558-114746227 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr6:114746228-114746898 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr6:114746899-114747567 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr6:114747568-114748238 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr6:114748909-114749578 Neighboring gene lncRNA periodontal mesenchymal stem cell osteogenesis related

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Phenotypes

    EBI GWAS Catalog

    Description
    Genome-wide association analysis with gray matter volume as a quantitative phenotype in first-episode treatment-naïve patients with schizophrenia.
    EBI GWAS Catalog

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    General protein information

    Preferred Names
    heparan sulfate glucosamine 3-O-sulfotransferase 5
    Names
    h3-OST-5
    heparan sulfate (glucosamine) 3-O-sulfotransferase 5
    heparan sulfate 3-O-sulfotransferase 5
    heparan sulfate 3-OST-5
    heparan sulfate D-glucosaminyl 3-O-sulfotransferase 5
    NP_001373968.1
    NP_001373969.1
    NP_001373970.1
    NP_001373971.1
    NP_001373972.1
    NP_001373973.1
    NP_001373974.1
    NP_001373975.1
    NP_001373976.1
    NP_705840.2
    XP_011533890.1
    XP_016865960.1
    XP_054210617.1
    XP_054210618.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001387039.1NP_001373968.1  heparan sulfate glucosamine 3-O-sulfotransferase 5

      Status: VALIDATED

      Source sequence(s)
      AL136446, AL355498, AL500524
      Consensus CDS
      CCDS34517.1
      UniProtKB/Swiss-Prot
      A8K1J2, Q52LI2, Q8IZT8, Q8N285
      Conserved Domains (1) summary
      pfam00685
      Location:90330
      Sulfotransfer_1; Sulfotransferase domain
    2. NM_001387040.1NP_001373969.1  heparan sulfate glucosamine 3-O-sulfotransferase 5

      Status: VALIDATED

      Source sequence(s)
      AL136446, AL355498
      Consensus CDS
      CCDS34517.1
      UniProtKB/Swiss-Prot
      A8K1J2, Q52LI2, Q8IZT8, Q8N285
      Conserved Domains (1) summary
      pfam00685
      Location:90330
      Sulfotransfer_1; Sulfotransferase domain
    3. NM_001387041.1NP_001373970.1  heparan sulfate glucosamine 3-O-sulfotransferase 5

      Status: VALIDATED

      Source sequence(s)
      AL136446, AL355498, AL500524
      Consensus CDS
      CCDS34517.1
      UniProtKB/Swiss-Prot
      A8K1J2, Q52LI2, Q8IZT8, Q8N285
      Conserved Domains (1) summary
      pfam00685
      Location:90330
      Sulfotransfer_1; Sulfotransferase domain
    4. NM_001387042.1NP_001373971.1  heparan sulfate glucosamine 3-O-sulfotransferase 5

      Status: VALIDATED

      Source sequence(s)
      AL136446, AL355498, AL500524
      Consensus CDS
      CCDS34517.1
      UniProtKB/Swiss-Prot
      A8K1J2, Q52LI2, Q8IZT8, Q8N285
      Conserved Domains (1) summary
      pfam00685
      Location:90330
      Sulfotransfer_1; Sulfotransferase domain
    5. NM_001387043.1NP_001373972.1  heparan sulfate glucosamine 3-O-sulfotransferase 5

      Status: VALIDATED

      Source sequence(s)
      AL136446, AL355498, AL500524
      Consensus CDS
      CCDS34517.1
      UniProtKB/Swiss-Prot
      A8K1J2, Q52LI2, Q8IZT8, Q8N285
      Conserved Domains (1) summary
      pfam00685
      Location:90330
      Sulfotransfer_1; Sulfotransferase domain
    6. NM_001387044.1NP_001373973.1  heparan sulfate glucosamine 3-O-sulfotransferase 5

      Status: VALIDATED

      Source sequence(s)
      AL136446, AL355498, AL500524
      Consensus CDS
      CCDS34517.1
      UniProtKB/Swiss-Prot
      A8K1J2, Q52LI2, Q8IZT8, Q8N285
      Conserved Domains (1) summary
      pfam00685
      Location:90330
      Sulfotransfer_1; Sulfotransferase domain
    7. NM_001387045.1NP_001373974.1  heparan sulfate glucosamine 3-O-sulfotransferase 5

      Status: VALIDATED

      Source sequence(s)
      AL136446, AL355498, AL500524
      Consensus CDS
      CCDS34517.1
      UniProtKB/Swiss-Prot
      A8K1J2, Q52LI2, Q8IZT8, Q8N285
      Conserved Domains (1) summary
      pfam00685
      Location:90330
      Sulfotransfer_1; Sulfotransferase domain
    8. NM_001387046.1NP_001373975.1  heparan sulfate glucosamine 3-O-sulfotransferase 5

      Status: VALIDATED

      Source sequence(s)
      AL136446, AL355498, AL500524
      Consensus CDS
      CCDS34517.1
      UniProtKB/Swiss-Prot
      A8K1J2, Q52LI2, Q8IZT8, Q8N285
      Conserved Domains (1) summary
      pfam00685
      Location:90330
      Sulfotransfer_1; Sulfotransferase domain
    9. NM_001387047.1NP_001373976.1  heparan sulfate glucosamine 3-O-sulfotransferase 5

      Status: VALIDATED

      Source sequence(s)
      AL136446, AL355498, AL500524
      Consensus CDS
      CCDS34517.1
      UniProtKB/Swiss-Prot
      A8K1J2, Q52LI2, Q8IZT8, Q8N285
      Conserved Domains (1) summary
      pfam00685
      Location:90330
      Sulfotransfer_1; Sulfotransferase domain
    10. NM_153612.4NP_705840.2  heparan sulfate glucosamine 3-O-sulfotransferase 5

      See identical proteins and their annotated locations for NP_705840.2

      Status: VALIDATED

      Source sequence(s)
      AL136446, AL355498, AL500524
      Consensus CDS
      CCDS34517.1
      UniProtKB/Swiss-Prot
      A8K1J2, Q52LI2, Q8IZT8, Q8N285
      Related
      ENSP00000427888.1, ENST00000312719.10
      Conserved Domains (1) summary
      pfam00685
      Location:90330
      Sulfotransfer_1; Sulfotransferase domain

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000006.12 Reference GRCh38.p14 Primary Assembly

      Range
      114055596..114343023 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017010471.2XP_016865960.1  heparan sulfate glucosamine 3-O-sulfotransferase 5 isoform X1

      UniProtKB/Swiss-Prot
      A8K1J2, Q52LI2, Q8IZT8, Q8N285
      Conserved Domains (1) summary
      pfam00685
      Location:90330
      Sulfotransfer_1; Sulfotransferase domain
    2. XM_011535588.3XP_011533890.1  heparan sulfate glucosamine 3-O-sulfotransferase 5 isoform X1

      See identical proteins and their annotated locations for XP_011533890.1

      UniProtKB/Swiss-Prot
      A8K1J2, Q52LI2, Q8IZT8, Q8N285
      Conserved Domains (1) summary
      pfam00685
      Location:90330
      Sulfotransfer_1; Sulfotransferase domain

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060930.1 Alternate T2T-CHM13v2.0

      Range
      115238715..115526173 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054354642.1XP_054210617.1  heparan sulfate glucosamine 3-O-sulfotransferase 5 isoform X1

      UniProtKB/Swiss-Prot
      A8K1J2, Q52LI2, Q8IZT8, Q8N285
    2. XM_054354643.1XP_054210618.1  heparan sulfate glucosamine 3-O-sulfotransferase 5 isoform X1

      UniProtKB/Swiss-Prot
      A8K1J2, Q52LI2, Q8IZT8, Q8N285