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    Umps uridine monophosphate synthetase [ Mus musculus (house mouse) ]

    Gene ID: 22247, updated on 22-Aug-2021

    Summary

    Official Symbol
    Umpsprovided by MGI
    Official Full Name
    uridine monophosphate synthetaseprovided by MGI
    Primary source
    MGI:MGI:1298388
    See related
    Ensembl:ENSMUSG00000022814
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    AA408257; AL033308; BB164745; 1700095D23Rik
    Expression
    Ubiquitous expression in liver E14 (RPKM 16.6), liver E14.5 (RPKM 14.9) and 28 other tissues See more
    Orthologs
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    Genomic context

    See Umps in Genome Data Viewer
    Location:
    16; 16 B3
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 16 NC_000082.7 (33775152..33787408, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 16 NC_000082.6 (33954782..33967038, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 16 NC_000082.5 (33955098..33967089, complement)

    Chromosome 16 - NC_000082.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 34967 Neighboring gene integrin beta 5 Neighboring gene kalirin, RhoGEF kinase Neighboring gene VISTA enhancer mm268 Neighboring gene predicted gene, 41448

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Gene trapped (1) 

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables carboxy-lyase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables catalytic activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables glycosyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables lyase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables orotate phosphoribosyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables orotate phosphoribosyltransferase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables orotate phosphoribosyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables orotidine-5'-phosphate decarboxylase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables orotidine-5'-phosphate decarboxylase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables orotidine-5'-phosphate decarboxylase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    uridine 5'-monophosphate synthase
    Names
    UMP synthase
    NP_001335016.1
    NP_033497.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001348087.1NP_001335016.1  uridine 5'-monophosphate synthase isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR, lacks an in-frame portion of the 5' coding region, and uses a downstream start codon compared to variant 1. The resulting isoform (2) has a shorter N-terminus, compared to isoform 1.
      Source sequence(s)
      AC165079, AK035997
      Conserved Domains (1) summary
      pfam00215
      Location:74288
      OMPdecase; Orotidine 5'-phosphate decarboxylase / HUMPS family
    2. NM_009471.3NP_033497.1  uridine 5'-monophosphate synthase isoform 1

      See identical proteins and their annotated locations for NP_033497.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AC165079, AK035821, BM219105
      Consensus CDS
      CCDS28136.1
      UniProtKB/Swiss-Prot
      P13439
      UniProtKB/TrEMBL
      Q544K9
      Related
      ENSMUSP00000023510.7, ENSMUST00000023510.7
      Conserved Domains (2) summary
      pfam00215
      Location:252466
      OMPdecase; Orotidine 5'-phosphate decarboxylase / HUMPS family
      cl00309
      Location:9204
      PRTases_typeI; Phosphoribosyl transferase (PRT)-type I domain

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000082.7 Reference GRCm39 C57BL/6J

      Range
      33775152..33787408 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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