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    Umps uridine monophosphate synthetase [ Mus musculus (house mouse) ]

    Gene ID: 22247, updated on 5-Aug-2018

    Summary

    Official Symbol
    Umpsprovided by MGI
    Official Full Name
    uridine monophosphate synthetaseprovided by MGI
    Primary source
    MGI:MGI:1298388
    See related
    Ensembl:ENSMUSG00000022814 Vega:OTTMUSG00000031003
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    AA408257; AL033308; BB164745; 1700095D23Rik
    Expression
    Ubiquitous expression in liver E14 (RPKM 16.6), liver E14.5 (RPKM 14.9) and 28 other tissues See more
    Orthologs

    Genomic context

    See Umps in Genome Data Viewer
    Location:
    16; 16 B3
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 16 NC_000082.6 (33954784..33967003, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 16 NC_000082.5 (33955098..33967089, complement)

    Chromosome 16 - NC_000082.6Genomic Context describing neighboring genes Neighboring gene predicted gene, 34967 Neighboring gene integrin beta 5 Neighboring gene kalirin, RhoGEF kinase Neighboring gene predicted gene, 46566 Neighboring gene predicted gene, 41448

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Gene trapped (1) 

    Pathways from BioSystems

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    carboxy-lyase activity IEA
    Inferred from Electronic Annotation
    more info
     
    catalytic activity IEA
    Inferred from Electronic Annotation
    more info
     
    identical protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    lyase activity IEA
    Inferred from Electronic Annotation
    more info
     
    orotate phosphoribosyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
     
    orotidine-5'-phosphate decarboxylase activity ISO
    Inferred from Sequence Orthology
    more info
     
    transferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    transferase activity, transferring glycosyl groups IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    'de novo' UMP biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
     
    'de novo' pyrimidine nucleobase biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
     
    UMP biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
     
    metabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    nucleoside metabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    pyrimidine nucleotide biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    nucleus ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    uridine 5'-monophosphate synthase
    Names
    UMP synthase
    NP_033497.1
    XP_006522071.1

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001348087.1NP_001335016.1  uridine 5'-monophosphate synthase isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR, lacks an in-frame portion of the 5' coding region, and uses a downstream start codon compared to variant 1. The resulting isoform (2) has a shorter N-terminus, compared to isoform 1.
      Source sequence(s)
      AC165079, AK035997
      Conserved Domains (1) summary
      pfam00215
      Location:74288
      OMPdecase; Orotidine 5'-phosphate decarboxylase / HUMPS family
    2. NM_009471.3NP_033497.1  uridine 5'-monophosphate synthase isoform 1

      See identical proteins and their annotated locations for NP_033497.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AC165079, AK035821, BM219105
      Consensus CDS
      CCDS28136.1
      UniProtKB/Swiss-Prot
      P13439
      UniProtKB/TrEMBL
      Q544K9
      Related
      ENSMUSP00000023510.6, OTTMUSP00000032775, ENSMUST00000023510.6, OTTMUST00000065699
      Conserved Domains (2) summary
      pfam00215
      Location:252466
      OMPdecase; Orotidine 5'-phosphate decarboxylase / HUMPS family
      cl00309
      Location:9204
      PRTases_typeI; Phosphoribosyl transferase (PRT)-type I domain

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000082.6 Reference GRCm38.p4 C57BL/6J

      Range
      33954784..33967003 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006522008.3XP_006522071.1  uridine 5'-monophosphate synthase isoform X1

      See identical proteins and their annotated locations for XP_006522071.1

      Conserved Domains (1) summary
      pfam00215
      Location:74288
      OMPdecase; Orotidine 5'-phosphate decarboxylase / HUMPS family
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