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    Usp10 ubiquitin specific peptidase 10 [ Mus musculus (house mouse) ]

    Gene ID: 22224, updated on 13-Nov-2018

    Summary

    Official Symbol
    Usp10provided by MGI
    Official Full Name
    ubiquitin specific peptidase 10provided by MGI
    Primary source
    MGI:MGI:894652
    See related
    Ensembl:ENSMUSG00000031826 Vega:OTTMUSG00000026199
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    UBPO; Uchrp; mKIAA0190; 2610014N07Rik
    Expression
    Ubiquitous expression in CNS E11.5 (RPKM 13.5), limb E14.5 (RPKM 11.2) and 28 other tissues See more
    Orthologs

    Genomic context

    See Usp10 in Genome Data Viewer
    Location:
    8; 8 E1
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 8 NC_000074.6 (119910360..119957560)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 8 NC_000074.5 (122434752..122481457)

    Chromosome 8 - NC_000074.6Genomic Context describing neighboring genes Neighboring gene coactosin-like 1 (Dictyostelium) Neighboring gene kelch-like 36 Neighboring gene cysteine-rich secretory protein LCCL domain containing 2 Neighboring gene zinc finger, DHHC domain containing 7

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from BioSystems

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    cysteine-type endopeptidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    cysteine-type endopeptidase activity ISO
    Inferred from Sequence Orthology
    more info
     
    cysteine-type peptidase activity IEA
    Inferred from Electronic Annotation
    more info
     
    hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
     
    ion channel binding ISO
    Inferred from Sequence Orthology
    more info
     
    p53 binding ISO
    Inferred from Sequence Orthology
    more info
     
    peptidase activity IEA
    Inferred from Electronic Annotation
    more info
     
    thiol-dependent ubiquitin-specific protease activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    thiol-dependent ubiquitin-specific protease activity ISO
    Inferred from Sequence Orthology
    more info
     
    thiol-dependent ubiquitinyl hydrolase activity ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    DNA damage response, signal transduction by p53 class mediator IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    DNA damage response, signal transduction by p53 class mediator ISO
    Inferred from Sequence Orthology
    more info
     
    DNA repair IEA
    Inferred from Electronic Annotation
    more info
     
    autophagy IEA
    Inferred from Electronic Annotation
    more info
     
    cellular response to DNA damage stimulus ISO
    Inferred from Sequence Orthology
    more info
     
    cellular response to interleukin-1 ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of I-kappaB kinase/NF-kappaB signaling ISO
    Inferred from Sequence Orthology
    more info
     
    protein deubiquitination IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    protein deubiquitination ISO
    Inferred from Sequence Orthology
    more info
     
    proteolysis IEA
    Inferred from Electronic Annotation
    more info
     
    regulation of autophagy IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    regulation of autophagy ISO
    Inferred from Sequence Orthology
    more info
     
    ubiquitin-dependent protein catabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    early endosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    early endosome ISO
    Inferred from Sequence Orthology
    more info
     
    endosome IEA
    Inferred from Electronic Annotation
    more info
     
    nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    protein-containing complex ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    ubiquitin carboxyl-terminal hydrolase 10
    Names
    deubiquitinating enzyme 10
    ubiquintin c-terminal hydrolase related polypeptide
    ubiquitin specific protease 10
    ubiquitin thioesterase 10
    ubiquitin thiolesterase 10
    ubiquitin-specific-processing protease 10
    NP_001297559.1
    NP_033488.1
    XP_006530908.1
    XP_006530909.1

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001310630.1NP_001297559.1  ubiquitin carboxyl-terminal hydrolase 10 isoform 2

      See identical proteins and their annotated locations for NP_001297559.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses an alternate in-frame splice site in the 5' coding region compared to variant 1. It encodes isoform 2, which is shorter than isoform 1.
      Source sequence(s)
      AI846788, AK077453, AK153675, AK165156
      Consensus CDS
      CCDS80938.1
      UniProtKB/Swiss-Prot
      P52479
      Related
      ENSMUSP00000104616.2, OTTMUSP00000032198, ENSMUST00000108988.8, OTTMUST00000064754
      Conserved Domains (2) summary
      cd02257
      Location:514787
      Peptidase_C19; Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyse bonds involving the carboxyl group of the C-terminal Gly ...
      pfam00443
      Location:408786
      UCH; Ubiquitin carboxyl-terminal hydrolase
    2. NM_009462.2NP_033488.1  ubiquitin carboxyl-terminal hydrolase 10 isoform 1

      See identical proteins and their annotated locations for NP_033488.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AI846788, AK077453, AK153675, DV650223
      Consensus CDS
      CCDS40495.1
      UniProtKB/Swiss-Prot
      P52479
      Related
      ENSMUSP00000123590.1, OTTMUSP00000032197, ENSMUST00000144458.7, OTTMUST00000064753
      Conserved Domains (2) summary
      cd02257
      Location:515788
      Peptidase_C19; Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyse bonds involving the carboxyl group of the C-terminal Gly ...
      pfam00443
      Location:409787
      UCH; Ubiquitin carboxyl-terminal hydrolase

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000074.6 Reference GRCm38.p4 C57BL/6J

      Range
      119910360..119957560
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006530845.3XP_006530908.1  ubiquitin carboxyl-terminal hydrolase 10 isoform X1

      Conserved Domains (2) summary
      cd02257
      Location:540813
      Peptidase_C19; Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyse bonds involving the carboxyl group of the C-terminal Gly ...
      pfam00443
      Location:434812
      UCH; Ubiquitin carboxyl-terminal hydrolase
    2. XM_006530846.3XP_006530909.1  ubiquitin carboxyl-terminal hydrolase 10 isoform X2

      Conserved Domains (2) summary
      cd02257
      Location:539812
      Peptidase_C19; Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyse bonds involving the carboxyl group of the C-terminal Gly ...
      pfam00443
      Location:433811
      UCH; Ubiquitin carboxyl-terminal hydrolase
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