Format

Send to:

Choose Destination
    • Showing Current items.

    Usp10 ubiquitin specific peptidase 10 [ Mus musculus (house mouse) ]

    Gene ID: 22224, updated on 16-Oct-2021

    Summary

    Official Symbol
    Usp10provided by MGI
    Official Full Name
    ubiquitin specific peptidase 10provided by MGI
    Primary source
    MGI:MGI:894652
    See related
    Ensembl:ENSMUSG00000031826
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    UBPO; Uchrp; mKIAA0190; 2610014N07Rik
    Expression
    Ubiquitous expression in CNS E11.5 (RPKM 13.5), limb E14.5 (RPKM 11.2) and 28 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See Usp10 in Genome Data Viewer
    Location:
    8; 8 E1
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (120637099..120684299)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (119910360..119957560)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 8 NC_000074.5 (122434752..122481457)

    Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene kelch-like 36 Neighboring gene predicted gene, 53464 Neighboring gene cysteine-rich secretory protein LCCL domain containing 2 Neighboring gene zinc finger, DHHC domain containing 7

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables cysteine-type endopeptidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables cysteine-type endopeptidase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables cysteine-type peptidase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables p53 binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables peptidase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables thiol-dependent deubiquitinase IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables thiol-dependent deubiquitinase ISO
    Inferred from Sequence Orthology
    more info
     
    enables transmembrane transporter binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    involved_in DNA damage response, signal transduction by p53 class mediator IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in DNA damage response, signal transduction by p53 class mediator ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within DNA repair IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within autophagy IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cellular response to DNA damage stimulus ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cellular response to interleukin-1 ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of I-kappaB kinase/NF-kappaB signaling ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in protein deubiquitination IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in protein deubiquitination ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within proteolysis IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in regulation of autophagy IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in regulation of autophagy ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in ubiquitin-dependent protein catabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in early endosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in early endosome ISO
    Inferred from Sequence Orthology
    more info
     
    located_in endosome IEA
    Inferred from Electronic Annotation
    more info
     
    located_in intermediate filament cytoskeleton ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    part_of protein-containing complex ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    ubiquitin carboxyl-terminal hydrolase 10
    Names
    deubiquitinating enzyme 10
    ubiquintin c-terminal hydrolase related polypeptide
    ubiquitin specific protease 10
    ubiquitin thioesterase 10
    ubiquitin thiolesterase 10
    ubiquitin-specific-processing protease 10
    NP_001297559.1
    NP_033488.1
    XP_006530908.1
    XP_006530909.1
    XP_030099273.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001310630.1NP_001297559.1  ubiquitin carboxyl-terminal hydrolase 10 isoform 2

      See identical proteins and their annotated locations for NP_001297559.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses an alternate in-frame splice site in the 5' coding region compared to variant 1. It encodes isoform 2, which is shorter than isoform 1.
      Source sequence(s)
      AI846788, AK077453, AK153675, AK165156
      Consensus CDS
      CCDS80938.1
      UniProtKB/Swiss-Prot
      P52479
      Related
      ENSMUSP00000104616.3, ENSMUST00000108988.9
      Conserved Domains (2) summary
      cd02257
      Location:514787
      Peptidase_C19; Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyse bonds involving the carboxyl group of the C-terminal Gly ...
      pfam00443
      Location:408786
      UCH; Ubiquitin carboxyl-terminal hydrolase
    2. NM_009462.2NP_033488.1  ubiquitin carboxyl-terminal hydrolase 10 isoform 1

      See identical proteins and their annotated locations for NP_033488.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AI846788, AK077453, AK153675, DV650223
      Consensus CDS
      CCDS40495.1
      UniProtKB/Swiss-Prot
      P52479
      Related
      ENSMUSP00000123590.2, ENSMUST00000144458.8
      Conserved Domains (2) summary
      cd02257
      Location:515788
      Peptidase_C19; Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyse bonds involving the carboxyl group of the C-terminal Gly ...
      pfam00443
      Location:409787
      UCH; Ubiquitin carboxyl-terminal hydrolase

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000074.7 Reference GRCm39 C57BL/6J

      Range
      120637099..120684299
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006530845.4XP_006530908.1  ubiquitin carboxyl-terminal hydrolase 10 isoform X1

      Conserved Domains (2) summary
      pfam00443
      Location:435812
      UCH; Ubiquitin carboxyl-terminal hydrolase
      pfam05466
      Location:256413
      BASP1; Brain acid soluble protein 1 (BASP1 protein)
    2. XM_006530846.4XP_006530909.1  ubiquitin carboxyl-terminal hydrolase 10 isoform X2

      Conserved Domains (2) summary
      pfam00443
      Location:434811
      UCH; Ubiquitin carboxyl-terminal hydrolase
      pfam05466
      Location:255412
      BASP1; Brain acid soluble protein 1 (BASP1 protein)
    3. XM_030243413.2XP_030099273.1  ubiquitin carboxyl-terminal hydrolase 10 isoform X3

      Conserved Domains (1) summary
      cd02257
      Location:82355
      Peptidase_C19; Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyse bonds involving the carboxyl group of the C-terminal Gly ...
    Support Center