Format

Send to:

Choose Destination
    • Showing Current items.

    Uchl1 ubiquitin carboxy-terminal hydrolase L1 [ Mus musculus (house mouse) ]

    Gene ID: 22223, updated on 18-Nov-2018

    Summary

    Official Symbol
    Uchl1provided by MGI
    Official Full Name
    ubiquitin carboxy-terminal hydrolase L1provided by MGI
    Primary source
    MGI:MGI:103149
    See related
    Ensembl:ENSMUSG00000029223 Vega:OTTMUSG00000042268
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    gad; C88048; PGP9.5; R75593; UCH-L1; UCHL-1; PGP 9.5; AW822034
    Expression
    Biased expression in CNS E18 (RPKM 511.8), whole brain E14.5 (RPKM 348.5) and 9 other tissues See more
    Orthologs

    Genomic context

    See Uchl1 in Genome Data Viewer
    Location:
    5 C3.1; 5 35.95 cM
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 5 NC_000071.6 (66676121..66687234)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 5 NC_000071.5 (67067360..67078473)

    Chromosome 5 - NC_000071.6Genomic Context describing neighboring genes Neighboring gene predicted gene 15794 Neighboring gene NOL1/NOP2/Sun domain family, member 7 Neighboring gene amyloid beta (A4) precursor protein-binding, family B, member 2 Neighboring gene ubiquitin carboxy-terminal hydrolase L1, opposite strand Neighboring gene LIM and calponin homology domains 1 Neighboring gene predicted gene 6517 Neighboring gene eukaryotic translation elongation factor 1 gamma pseudogene

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from BioSystems

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    alpha-2A adrenergic receptor binding ISO
    Inferred from Sequence Orthology
    more info
     
    cysteine-type endopeptidase activity ISO
    Inferred from Sequence Orthology
    more info
     
    cysteine-type peptidase activity IEA
    Inferred from Electronic Annotation
    more info
     
    hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
     
    ligase activity IEA
    Inferred from Electronic Annotation
    more info
     
    omega peptidase activity ISO
    Inferred from Sequence Orthology
    more info
     
    peptidase activity IEA
    Inferred from Electronic Annotation
    more info
     
    thiol-dependent ubiquitin-specific protease activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    thiol-dependent ubiquitin-specific protease activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    thiol-dependent ubiquitin-specific protease activity ISO
    Inferred from Sequence Orthology
    more info
     
    thiol-dependent ubiquitinyl hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
     
    ubiquitin binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    ubiquitin binding ISO
    Inferred from Sequence Orthology
    more info
     
    ubiquitin protein ligase binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    adult walking behavior IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    adult walking behavior IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    axon target recognition IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    axonal transport of mitochondrion IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    axonogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    cell proliferation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    eating behavior IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    muscle fiber development IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    negative regulation of MAP kinase activity ISO
    Inferred from Sequence Orthology
    more info
     
    neuromuscular process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    protein deubiquitination IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    protein deubiquitination ISO
    Inferred from Sequence Orthology
    more info
     
    proteolysis IEA
    Inferred from Electronic Annotation
    more info
     
    response to ischemia IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    sensory perception of pain ISO
    Inferred from Sequence Orthology
    more info
     
    ubiquitin-dependent protein catabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    axon IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    cytosol IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    endoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
     
    membrane IEA
    Inferred from Electronic Annotation
    more info
     
    myelin sheath IDA
    Inferred from Direct Assay
    more info
    PubMed 
    neuron projection terminus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    neuronal cell body IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    colocalizes_with plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    ubiquitin carboxyl-terminal hydrolase isozyme L1
    Names
    gracile axonal dystrophy
    neuron cytoplasmic protein 9.5
    protein gene product 9.5
    ubiquitin thioesterase L1
    NP_035800.2

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_011670.2NP_035800.2  ubiquitin carboxyl-terminal hydrolase isozyme L1

      See identical proteins and their annotated locations for NP_035800.2

      Status: VALIDATED

      Source sequence(s)
      AF172334, AK013729, CX241178
      Consensus CDS
      CCDS19315.1
      UniProtKB/Swiss-Prot
      Q9R0P9
      Related
      ENSMUSP00000031131.9, OTTMUSP00000062165, ENSMUST00000031131.10, OTTMUST00000111175
      Conserved Domains (1) summary
      cd09616
      Location:5219
      Peptidase_C12_UCH_L1_L3; Cysteine peptidase C12 containing ubiquitin carboxyl-terminal hydrolase (UCH) families L1 and L3

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000071.6 Reference GRCm38.p4 C57BL/6J

      Range
      66676121..66687234
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Support Center