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    Sumo1 small ubiquitin-like modifier 1 [ Mus musculus (house mouse) ]

    Gene ID: 22218, updated on 12-Aug-2018

    Summary

    Official Symbol
    Sumo1provided by MGI
    Official Full Name
    small ubiquitin-like modifier 1provided by MGI
    Primary source
    MGI:MGI:1197010
    See related
    Ensembl:ENSMUSG00000026021 Vega:OTTMUSG00000022159
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    GMP1; PIC1; SMT3; Ubl1; SMTP3; Smt3C; SMT3H3; SUMO-1; SENTRIN
    Expression
    Broad expression in CNS E11.5 (RPKM 56.9), CNS E14 (RPKM 40.0) and 21 other tissues See more
    Orthologs

    Genomic context

    See Sumo1 in Genome Data Viewer
    Location:
    1; 1 C2
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 1 NC_000067.6 (59639434..59670834, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 1 NC_000067.5 (59696278..59727678, complement)

    Chromosome 1 - NC_000067.6Genomic Context describing neighboring genes Neighboring gene predicted gene 973 Neighboring gene predicted gene, 39648 Neighboring gene predicted gene, 33833 Neighboring gene NOP58 ribonucleoprotein Neighboring gene small nucleolar RNA, C/D box 70 Neighboring gene small nucleolar RNA, C/D box 11

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from BioSystems

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • MGC103203

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    SUMO transferase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enzyme binding ISO
    Inferred from Sequence Orthology
    more info
     
    glucocorticoid receptor binding ISO
    Inferred from Sequence Orthology
    more info
     
    potassium channel regulator activity ISO
    Inferred from Sequence Orthology
    more info
     
    protein C-terminus binding ISO
    Inferred from Sequence Orthology
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein binding, bridging ISO
    Inferred from Sequence Orthology
    more info
     
    protein tag IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    small protein activating enzyme binding ISO
    Inferred from Sequence Orthology
    more info
     
    transcription corepressor binding ISO
    Inferred from Sequence Orthology
    more info
     
    transcription factor binding IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    transcription factor binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    ubiquitin protein ligase binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    PML body organization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    cellular response to cadmium ion ISO
    Inferred from Sequence Orthology
    more info
     
    cellular response to heat ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of DNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of DNA-binding transcription factor activity ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of action potential ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of delayed rectifier potassium channel activity ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of transcription, DNA-templated ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of calcium-transporting ATPase activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of proteasomal ubiquitin-dependent protein catabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of protein complex assembly ISO
    Inferred from Sequence Orthology
    more info
     
    protein localization to nuclear pore IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    protein stabilization ISO
    Inferred from Sequence Orthology
    more info
     
    protein sumoylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    protein sumoylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    protein sumoylation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    protein sumoylation ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of calcium ion transmembrane transport IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of cardiac muscle cell contraction IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of protein stability IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of transcription, DNA-templated IDA
    Inferred from Direct Assay
    more info
    PubMed 
    roof of mouth development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    PML body ISO
    Inferred from Sequence Orthology
    more info
     
    colocalizes_with PML body ISO
    Inferred from Sequence Orthology
    more info
     
    PML body TAS
    Traceable Author Statement
    more info
    PubMed 
    SUMO activating enzyme complex ISO
    Inferred from Sequence Orthology
    more info
     
    XY body IDA
    Inferred from Direct Assay
    more info
    PubMed 
    XY body ISO
    Inferred from Sequence Orthology
    more info
     
    cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    dendrite ISO
    Inferred from Sequence Orthology
    more info
     
    fibrillar center ISO
    Inferred from Sequence Orthology
    more info
     
    colocalizes_with heterochromatin ISO
    Inferred from Sequence Orthology
    more info
     
    membrane IEA
    Inferred from Electronic Annotation
    more info
     
    nuclear body IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nuclear body ISO
    Inferred from Sequence Orthology
    more info
     
    nuclear membrane ISO
    Inferred from Sequence Orthology
    more info
     
    nuclear stress granule ISO
    Inferred from Sequence Orthology
    more info
     
    nucleolus ISO
    Inferred from Sequence Orthology
    more info
     
    nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    synapse ISO
    Inferred from Sequence Orthology
    more info
     
    colocalizes_with voltage-gated potassium channel complex ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    small ubiquitin-related modifier 1
    Names
    SMT3 homolog 3
    SMT3 suppressor of mif two 3 homolog 1
    SUMO-1 related peptidase
    ubiquitin-homology domain protein PIC1
    ubiquitin-like 1
    ubiquitin-like protein SMT3C

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_009460.2NP_033486.1  small ubiquitin-related modifier 1 precursor

      See identical proteins and their annotated locations for NP_033486.1

      Status: VALIDATED

      Source sequence(s)
      AK159366, BC082566, BE691755, BY242724
      Consensus CDS
      CCDS35586.1
      UniProtKB/Swiss-Prot
      P63166
      Related
      ENSMUSP00000088935.2, OTTMUSP00000024972, ENSMUST00000091374.8, OTTMUST00000052620
      Conserved Domains (1) summary
      cd01763
      Location:1197
      Sumo; Small ubiquitin-related modifier (SUMO)

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000067.6 Reference GRCm38.p4 C57BL/6J

      Range
      59639434..59670834 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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