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    Ube2h ubiquitin-conjugating enzyme E2H [ Mus musculus (house mouse) ]

    Gene ID: 22214, updated on 5-Aug-2018

    Summary

    Official Symbol
    Ube2hprovided by MGI
    Official Full Name
    ubiquitin-conjugating enzyme E2Hprovided by MGI
    Primary source
    MGI:MGI:104632
    See related
    Ensembl:ENSMUSG00000039159 Vega:OTTMUSG00000014347
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Gid3; Ubc8; E2-20K; N28148; AI181839; AI326965; AI462483; AW227540; 1500009C23Rik
    Expression
    Ubiquitous expression in ovary adult (RPKM 28.8), bladder adult (RPKM 28.5) and 28 other tissues See more
    Orthologs

    Genomic context

    See Ube2h in Genome Data Viewer
    Location:
    6 A3.3; 6 12.52 cM
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 6 NC_000072.6 (30211289..30304539, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 6 NC_000072.5 (30161289..30254539, complement)

    Chromosome 6 - NC_000072.6Genomic Context describing neighboring genes Neighboring gene expressed sequence BB283400 Neighboring gene predicted gene, 31221 Neighboring gene zinc finger, C3HC type 1 Neighboring gene kelch domain containing 10

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Gene trapped (1) 
    • Targeted (1) 

    Pathways from BioSystems

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
     
    transferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    ubiquitin conjugating enzyme activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    ubiquitin conjugating enzyme activity IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    ubiquitin-protein transferase activity ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    proteasome-mediated ubiquitin-dependent protein catabolic process IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    protein K11-linked ubiquitination ISO
    Inferred from Sequence Orthology
    more info
     
    protein K48-linked ubiquitination ISO
    Inferred from Sequence Orthology
    more info
     
    ubiquitin-dependent protein catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 

    General protein information

    Preferred Names
    ubiquitin-conjugating enzyme E2 H
    Names
    (E3-independent) E2 ubiquitin-conjugating enzyme H
    E2 ubiquitin-conjugating enzyme H
    UBCH2
    ubiquitin carrier protein H
    ubiquitin-conjugating enzyme E2-20K
    ubiquitin-protein ligase H
    NP_001163047.1
    NP_001163048.1
    NP_033485.1
    XP_017177008.1

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001169576.1NP_001163047.1  ubiquitin-conjugating enzyme E2 H isoform 2

      See identical proteins and their annotated locations for NP_001163047.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an alternate in-frame segment compared to variant 1. The resulting isoform (2) has the same N- and C-termini but is shorter compared to isoform 1.
      Source sequence(s)
      AC161538, AK131688, AK161414, CF539343
      Consensus CDS
      CCDS51743.1
      UniProtKB/TrEMBL
      E9Q3U1, Q3TTE3, Q3V2N4
      Related
      ENSMUSP00000092121.2, OTTMUSP00000015181, ENSMUST00000094543.2, OTTMUST00000033900
      Conserved Domains (1) summary
      cl00154
      Location:31114
      UBCc; Ubiquitin-conjugating enzyme E2, catalytic (UBCc) domain. This is part of the ubiquitin-mediated protein degradation pathway in which a thiol-ester linkage forms between a conserved cysteine and the C-terminus of ubiquitin and complexes with ubiquitin ...
    2. NM_001169577.1NP_001163048.1  ubiquitin-conjugating enzyme E2 H isoform 3

      See identical proteins and their annotated locations for NP_001163048.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (3) is shorter at the N-terminus compared to isoform 1.
      Source sequence(s)
      AC161538
      Conserved Domains (1) summary
      cl00154
      Location:175
      UBCc; Ubiquitin-conjugating enzyme E2, catalytic (UBCc) domain. This is part of the ubiquitin-mediated protein degradation pathway in which a thiol-ester linkage forms between a conserved cysteine and the C-terminus of ubiquitin and complexes with ubiquitin ...
    3. NM_009459.3NP_033485.1  ubiquitin-conjugating enzyme E2 H isoform 1

      See identical proteins and their annotated locations for NP_033485.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
      Source sequence(s)
      AC161538, AK131688, CF539343
      Consensus CDS
      CCDS19969.1
      UniProtKB/Swiss-Prot
      P62257
      UniProtKB/TrEMBL
      Q3V2N4
      Related
      ENSMUSP00000100058.3, OTTMUSP00000015180, ENSMUST00000102993.9, OTTMUST00000033899
      Conserved Domains (1) summary
      pfam00179
      Location:31145
      UQ_con; Ubiquitin-conjugating enzyme

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000072.6 Reference GRCm38.p4 C57BL/6J

      Range
      30211289..30304539 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017321519.1XP_017177008.1  ubiquitin-conjugating enzyme E2 H isoform X1

      Conserved Domains (1) summary
      cl00154
      Location:175
      UBCc; Ubiquitin-conjugating enzyme E2, catalytic (UBCc) domain. This is part of the ubiquitin-mediated protein degradation pathway in which a thiol-ester linkage forms between a conserved cysteine and the C-terminus of ubiquitin and complexes with ubiquitin ...
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