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    Ube2a ubiquitin-conjugating enzyme E2A [ Mus musculus (house mouse) ]

    Gene ID: 22209, updated on 31-Jan-2019

    Summary

    Official Symbol
    Ube2aprovided by MGI
    Official Full Name
    ubiquitin-conjugating enzyme E2Aprovided by MGI
    Primary source
    MGI:MGI:102959
    See related
    Ensembl:ENSMUSG00000016308
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    HR6A; HHR6A; Mhr6a
    Expression
    Ubiquitous expression in placenta adult (RPKM 13.3), CNS E18 (RPKM 11.1) and 28 other tissues See more
    Orthologs

    Genomic context

    See Ube2a in Genome Data Viewer
    Location:
    X; X A3.3
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) X NC_000086.7 (36874295..36884222)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) X NC_000086.6 (34414361..34424217)

    Chromosome X - NC_000086.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA C330007P06 gene Neighboring gene mitochondrial dynamic related lncRNA Neighboring gene 60S ribosomal protein L39 pseudogene Neighboring gene NF-kappaB repressing factor Neighboring gene predicted gene 15008 Neighboring gene septin 6

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from BioSystems

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    transferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    ubiquitin conjugating enzyme activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    ubiquitin conjugating enzyme activity IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    ubiquitin conjugating enzyme activity ISO
    Inferred from Sequence Orthology
    more info
     
    ubiquitin protein ligase binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    ubiquitin protein ligase binding ISO
    Inferred from Sequence Orthology
    more info
     
    ubiquitin-protein transferase activity ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    DNA repair IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    DNA repair ISO
    Inferred from Sequence Orthology
    more info
     
    blastocyst hatching IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    cellular response to DNA damage stimulus IEA
    Inferred from Electronic Annotation
    more info
     
    histone H2A ubiquitination ISO
    Inferred from Sequence Orthology
    more info
     
    in utero embryonic development IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    NOT in utero embryonic development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    maternal process involved in female pregnancy IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of cell proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    proteasome-mediated ubiquitin-dependent protein catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    protein K11-linked ubiquitination ISO
    Inferred from Sequence Orthology
    more info
     
    protein K48-linked ubiquitination ISO
    Inferred from Sequence Orthology
    more info
     
    protein autoubiquitination ISO
    Inferred from Sequence Orthology
    more info
     
    protein polyubiquitination IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    protein ubiquitination IDA
    Inferred from Direct Assay
    more info
    PubMed 
    response to UV ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    HULC complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    HULC complex ISO
    Inferred from Sequence Orthology
    more info
     
    XY body IDA
    Inferred from Direct Assay
    more info
    PubMed 
    chromatin IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nuclear chromatin IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    nuclear chromatin IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    ubiquitin-conjugating enzyme E2 A
    Names
    E2 ubiquitin-conjugating enzyme A
    RAD6 homolog A
    ubiquitin carrier protein A
    ubiquitin-conjugating enzyme E2A (RAD6 homolog)
    ubiquitin-conjugating enzyme HR6A
    ubiquitin-protein ligase A
    NP_001300625.1
    NP_062642.1

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001313696.1NP_001300625.1  ubiquitin-conjugating enzyme E2 A isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses an alternate in-frame splice junction in the 3' end compared to variant 1. The resulting isoform (2) has the same N- and C-termini but is shorter compared to isoform 1.
      Source sequence(s)
      AA013850, AK163966, AK164074, BE994531
      Consensus CDS
      CCDS85765.1
      UniProtKB/TrEMBL
      Q3TQ27, Q3UCS1
      Related
      ENSMUSP00000144242.1, ENSMUST00000202991.3
      Conserved Domains (1) summary
      pfam00179
      Location:8142
      UQ_con; Ubiquitin-conjugating enzyme
    2. NM_019668.4NP_062642.1  ubiquitin-conjugating enzyme E2 A isoform 1

      See identical proteins and their annotated locations for NP_062642.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AA013850, AK164074, BE994531
      Consensus CDS
      CCDS30064.1
      UniProtKB/Swiss-Prot
      Q9Z255
      UniProtKB/TrEMBL
      Q3UCS1
      Related
      ENSMUSP00000016452.7, ENSMUST00000016452.10
      Conserved Domains (1) summary
      pfam00179
      Location:8145
      UQ_con; Ubiquitin-conjugating enzyme

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000086.7 Reference GRCm38.p4 C57BL/6J

      Range
      36874295..36884222
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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