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    Ube2l3 ubiquitin-conjugating enzyme E2L 3 [ Mus musculus (house mouse) ]

    Gene ID: 22195, updated on 2-Oct-2018

    Summary

    Official Symbol
    Ube2l3provided by MGI
    Official Full Name
    ubiquitin-conjugating enzyme E2L 3provided by MGI
    Primary source
    MGI:MGI:109240
    See related
    Ensembl:ENSMUSG00000038965 Vega:OTTMUSG00000025066
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    UbcM4; Ubce7; C79827
    Expression
    Ubiquitous expression in adrenal adult (RPKM 45.0), liver E14 (RPKM 37.4) and 28 other tissues See more
    Orthologs

    Genomic context

    See Ube2l3 in Genome Data Viewer
    Location:
    16 A3; 16 10.63 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 16 NC_000082.6 (17152015..17201512, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 16 NC_000082.5 (17152108..17201585, complement)

    Chromosome 16 - NC_000082.6Genomic Context describing neighboring genes Neighboring gene Rps20 pseudogene Neighboring gene coiled-coil domain containing 116 Neighboring gene YdjC homolog (bacterial) Neighboring gene RIMS binding protein 3 Neighboring gene hypermethylated in cancer 2

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from BioSystems

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • MGC118100

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    transcription coactivator activity ISO
    Inferred from Sequence Orthology
    more info
     
    transferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    ubiquitin conjugating enzyme activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    ubiquitin conjugating enzyme activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    ubiquitin conjugating enzyme activity ISO
    Inferred from Sequence Orthology
    more info
     
    ubiquitin protein ligase binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    ubiquitin protein ligase binding ISO
    Inferred from Sequence Orthology
    more info
     
    ubiquitin-protein transferase activator activity ISO
    Inferred from Sequence Orthology
    more info
     
    ubiquitin-protein transferase activity ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    cell cycle phase transition ISO
    Inferred from Sequence Orthology
    more info
     
    cell proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    cellular response to glucocorticoid stimulus ISO
    Inferred from Sequence Orthology
    more info
     
    cellular response to steroid hormone stimulus ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of protein ubiquitination ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of ubiquitin-protein transferase activity ISO
    Inferred from Sequence Orthology
    more info
     
    protein K11-linked ubiquitination IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    protein K11-linked ubiquitination ISO
    Inferred from Sequence Orthology
    more info
     
    protein polyubiquitination ISO
    Inferred from Sequence Orthology
    more info
     
    protein ubiquitination ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of catalytic activity ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of transcription, DNA-templated ISO
    Inferred from Sequence Orthology
    more info
     
    ubiquitin-dependent protein catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    ubiquitin-dependent protein catabolic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    ubiquitin ligase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 

    General protein information

    Preferred Names
    ubiquitin-conjugating enzyme E2 L3
    Names
    E2 ubiquitin-conjugating enzyme L3
    ubiquitin carrier protein L3
    ubiquitin-conjugating enzyme 7
    ubiquitin-protein ligase L3
    NP_033482.1
    XP_006522067.1

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_009456.2NP_033482.1  ubiquitin-conjugating enzyme E2 L3

      See identical proteins and their annotated locations for NP_033482.1

      Status: PROVISIONAL

      Source sequence(s)
      AC154667
      Consensus CDS
      CCDS27997.1
      UniProtKB/Swiss-Prot
      P68037
      UniProtKB/TrEMBL
      Q561N4
      Related
      ENSMUSP00000087658.5, ENSMUST00000090192.11
      Conserved Domains (1) summary
      smart00212
      Location:6149
      UBCc; Ubiquitin-conjugating enzyme E2, catalytic domain homologues

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000082.6 Reference GRCm38.p4 C57BL/6J

      Range
      17152015..17201512 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006522004.3XP_006522067.1  ubiquitin-conjugating enzyme E2 L3 isoform X1

      See identical proteins and their annotated locations for XP_006522067.1

      Related
      ENSMUSP00000156336.1, ENSMUST00000231643.1
      Conserved Domains (1) summary
      pfam00179
      Location:9112
      UQ_con; Ubiquitin-conjugating enzyme
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