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    Ube2e3 ubiquitin-conjugating enzyme E2E 3 [ Mus musculus (house mouse) ]

    Gene ID: 22193, updated on 23-Jun-2021

    Summary

    Official Symbol
    Ube2e3provided by MGI
    Official Full Name
    ubiquitin-conjugating enzyme E2E 3provided by MGI
    Primary source
    MGI:MGI:107412
    See related
    Ensembl:ENSMUSG00000027011
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Ubce4; ubcM2
    Expression
    Ubiquitous expression in whole brain E14.5 (RPKM 33.4), CNS E14 (RPKM 32.5) and 28 other tissues See more
    Orthologs
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    Genomic context

    See Ube2e3 in Genome Data Viewer
    Location:
    2; 2 C3
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (78698577..78759130)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (78868236..78928786)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 2 NC_000068.6 (78709204..78760740)

    Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene predicted gene, 39865 Neighboring gene predicted gene 17014 Neighboring gene predicted gene, 51431 Neighboring gene predicted gene, 37004 Neighboring gene predicted gene, 35748

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Gene trapped (1) 
    • Endonuclease-mediated (1) 

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables ubiquitin conjugating enzyme activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables ubiquitin conjugating enzyme activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables ubiquitin-protein transferase activity ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    involved_in protein K11-linked ubiquitination IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in protein K11-linked ubiquitination ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in protein K48-linked ubiquitination IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in protein K48-linked ubiquitination ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in protein K63-linked ubiquitination IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in protein K63-linked ubiquitination ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in protein polyubiquitination IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    acts_upstream_of_or_within regulation of growth IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    ubiquitin-conjugating enzyme E2 E3
    Names
    E2 ubiquitin-conjugating enzyme E3
    ubiquitin carrier protein E3
    ubiquitin-conjugating enzyme 4
    ubiquitin-conjugating enzyme E2-23 kDa
    ubiquitin-conjugating enzyme E2E 3, UBC4/5 homolog
    ubiquitin-protein ligase E3
    NP_001343324.1
    NP_033480.1
    XP_006499225.1
    XP_006499226.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001356395.1NP_001343324.1  ubiquitin-conjugating enzyme E2 E3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2), as well as variant 1, is a protein-coding variant. Variants 1 and 2 both encode the same protein.
      Source sequence(s)
      AL772181, AL928604
      Consensus CDS
      CCDS16167.1
      Related
      ENSMUSP00000113463.2, ENSMUST00000121433.2
      Conserved Domains (1) summary
      pfam00179
      Location:65202
      UQ_con; Ubiquitin-conjugating enzyme
    2. NM_009454.2NP_033480.1  ubiquitin-conjugating enzyme E2 E3

      See identical proteins and their annotated locations for NP_033480.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1), as well as variant 2, is a protein-coding variant. Variants 1 and 2 both encode the same protein.
      Source sequence(s)
      BC011477
      Consensus CDS
      CCDS16167.1
      UniProtKB/Swiss-Prot
      P52483
      Related
      ENSMUSP00000028398.8, ENSMUST00000028398.14
      Conserved Domains (1) summary
      pfam00179
      Location:65202
      UQ_con; Ubiquitin-conjugating enzyme

    RNA

    1. NR_151457.1 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' and 3' ends compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AL772181, AL928604
    2. NR_151458.1 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) differs in the 5' and 3' ends compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AL772181, AL928604

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000068.8 Reference GRCm39 C57BL/6J

      Range
      78698577..78759130
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006499162.5XP_006499225.1  ubiquitin-conjugating enzyme E2 E3 isoform X1

      See identical proteins and their annotated locations for XP_006499225.1

      UniProtKB/Swiss-Prot
      P52483
      Conserved Domains (1) summary
      pfam00179
      Location:65202
      UQ_con; Ubiquitin-conjugating enzyme
    2. XM_006499163.4XP_006499226.1  ubiquitin-conjugating enzyme E2 E3 isoform X1

      See identical proteins and their annotated locations for XP_006499226.1

      UniProtKB/Swiss-Prot
      P52483
      Conserved Domains (1) summary
      pfam00179
      Location:65202
      UQ_con; Ubiquitin-conjugating enzyme
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