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    Ubb ubiquitin B [ Mus musculus (house mouse) ]

    Gene ID: 22187, updated on 27-Nov-2024

    Summary

    Official Symbol
    Ubbprovided by MGI
    Official Full Name
    ubiquitin Bprovided by MGI
    Primary source
    MGI:MGI:98888
    See related
    Ensembl:ENSMUSG00000019505 AllianceGenome:MGI:98888
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Ubc; Ubb2; Uba52; Rps27a
    Summary
    This gene encodes ubiquitin, one of the most conserved proteins known. Ubiquitin has a major role in targeting cellular proteins for degradation by the 26S proteosome. It is also involved in the maintenance of chromatin structure, the regulation of gene expression, and the stress response. Ubiquitin is synthesized as a precursor protein consisting of either polyubiquitin chains or a single ubiquitin moiety fused to an unrelated protein. This gene consists of four direct repeats of the ubiquitin coding sequence with no spacer sequence. Consequently, the protein is expressed as a polyubiquitin precursor with a final amino acid after the last repeat. Pseudogenes of this gene are located on chromosomes 3 and 14. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2015]
    Expression
    Ubiquitous expression in testis adult (RPKM 2757.3), whole brain E14.5 (RPKM 1808.9) and 28 other tissues See more
    Orthologs
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    Genomic context

    See Ubb in Genome Data Viewer
    Location:
    11 B2; 11 38.46 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (62442329..62444037)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (62551171..62553213)

    Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene centromere protein V Neighboring gene predicted gene 12279 Neighboring gene STARR-seq mESC enhancer starr_29713 Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:62387853-62388036 Neighboring gene transient receptor potential cation channel, subfamily V, member 2 Neighboring gene RIKEN cDNA 2410006H16 gene Neighboring gene STARR-positive B cell enhancer ABC_E9364 Neighboring gene small nucleolar RNA, C/D box 49B

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein tag activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables structural constituent of ribosome IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables ubiquitin protein ligase binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Process Evidence Code Pubs
    acts_upstream_of_or_within adipose tissue development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within energy homeostasis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within fat pad development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within female gonad development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within female meiosis I IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within hypothalamus gonadotrophin-releasing hormone neuron development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within male gonad development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within male meiosis I IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within mitochondrion transport along microtubule ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    involved_in modification-dependent protein catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    acts_upstream_of_or_within neuron projection morphogenesis ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    acts_upstream_of_or_within positive regulation of intrinsic apoptotic signaling pathway by p53 class mediator ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    involved_in positive regulation of protein monoubiquitination IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of protein monoubiquitination ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of protein ubiquitination ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in protein ubiquitination IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    acts_upstream_of_or_within regulation of mitochondrial membrane potential ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    acts_upstream_of_or_within regulation of neuron apoptotic process ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    acts_upstream_of_or_within regulation of proteasomal protein catabolic process ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    acts_upstream_of_or_within seminiferous tubule development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in cytosol TAS
    Traceable Author Statement
    more info
     
    located_in mitochondrial outer membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    located_in myelin sheath HDA PubMed 
    located_in neuron projection ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    located_in neuronal cell body ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    located_in nucleoplasm TAS
    Traceable Author Statement
    more info
     
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
     

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001313984.2NP_001300913.1  polyubiquitin-B precursor

      Status: VALIDATED

      Source sequence(s)
      AL596181
      Consensus CDS
      CCDS24826.1
      UniProtKB/Swiss-Prot
      P0CG49
      UniProtKB/TrEMBL
      Q78XY9, Q8R0Z9
      Conserved Domains (1) summary
      cd01803
      Location:77152
      Ubl_ubiquitin; ubiquitin-like (Ubl) domain found in ubiquitin
    2. NM_011664.5NP_035794.1  polyubiquitin-B precursor

      See identical proteins and their annotated locations for NP_035794.1

      Status: VALIDATED

      Source sequence(s)
      AL596181
      Consensus CDS
      CCDS24826.1
      UniProtKB/Swiss-Prot
      P0CG49
      UniProtKB/TrEMBL
      Q78XY9, Q8R0Z9
      Related
      ENSMUSP00000019649.4, ENSMUST00000019649.4
      Conserved Domains (1) summary
      cd01803
      Location:77152
      Ubl_ubiquitin; ubiquitin-like (Ubl) domain found in ubiquitin

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000077.7 Reference GRCm39 C57BL/6J

      Range
      62442329..62444037
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)