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    POLR1F RNA polymerase I subunit F [ Homo sapiens (human) ]

    Gene ID: 221830, updated on 7-Apr-2024

    Summary

    Official Symbol
    POLR1Fprovided by HGNC
    Official Full Name
    RNA polymerase I subunit Fprovided by HGNC
    Primary source
    HGNC:HGNC:18027
    See related
    Ensembl:ENSG00000105849 MIM:608312; AllianceGenome:HGNC:18027
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    A43; RPA43; TWISTNB
    Summary
    Predicted to enable DNA-directed 5'-3' RNA polymerase activity. Predicted to be involved in DNA-templated transcription, initiation. Predicted to act upstream of or within cellular response to leukemia inhibitory factor. Predicted to be located in nucleoplasm. Predicted to be part of RNA polymerase I complex. [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in endometrium (RPKM 8.5), bone marrow (RPKM 7.3) and 25 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See POLR1F in Genome Data Viewer
    Location:
    7p21.1
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 7 NC_000007.14 (19695461..19709037, complement)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 7 NC_060931.1 (19829933..19843507, complement)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (19735084..19748660, complement)

    Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105375179 Neighboring gene MPRA-validated peak6420 silencer Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_98149 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr7:19461410-19461934 Neighboring gene uncharacterized LOC105375180 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr7:19728484-19728984 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:19731604-19732104 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:19747784-19748388 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:19748389-19748991 Neighboring gene uncharacterized LOC107986774 Neighboring gene microRNA 3146 Neighboring gene transmembrane protein 196 Neighboring gene uncharacterized LOC105379720

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Phenotypes

    EBI GWAS Catalog

    Description
    Genome-Wide Association Study of Intracranial Aneurysm Identifies a New Association on Chromosome 7.
    EBI GWAS Catalog
    Hundreds of variants clustered in genomic loci and biological pathways affect human height.
    EBI GWAS Catalog
    Meta-analysis of genome-wide association studies of adult height in East Asians identifies 17 novel loci.
    EBI GWAS Catalog

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General protein information

    Preferred Names
    DNA-directed RNA polymerase I subunit RPA43
    Names
    DNA-directed RNA polymerase I subunit F
    twist neighbor protein

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001002926.2NP_001002926.1  DNA-directed RNA polymerase I subunit RPA43

      See identical proteins and their annotated locations for NP_001002926.1

      Status: VALIDATED

      Source sequence(s)
      AC004940, AK090846, BC056267
      Consensus CDS
      CCDS34606.1
      UniProtKB/Swiss-Prot
      A0PJ45, B7Z724, Q3B726
      Related
      ENSP00000222567.5, ENST00000222567.6
      Conserved Domains (2) summary
      cd04328
      Location:40126
      RNAP_I_Rpa43_N; Rpa43, N-terminal ribonucleoprotein (RNP) domain. Rpa43 is a subunit of eukaryotic RNA polymerase (RNAP) I that is homologous to Rpb7 of eukaryotic RNAP II, Rpc25 of eukaryotic RNP III, and RpoE of archaeal RNAP. Rpa43 has two domains, an N-terminal RNP ...
      pfam17875
      Location:125157
      RPA43_OB; RPA43 OB domain in RNA Pol I

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000007.14 Reference GRCh38.p14 Primary Assembly

      Range
      19695461..19709037 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060931.1 Alternate T2T-CHM13v2.0

      Range
      19829933..19843507 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)