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    Tubb3 tubulin, beta 3 class III [ Mus musculus (house mouse) ]

    Gene ID: 22152, updated on 18-Nov-2018

    Summary

    Official Symbol
    Tubb3provided by MGI
    Official Full Name
    tubulin, beta 3 class IIIprovided by MGI
    Primary source
    MGI:MGI:107813
    See related
    Ensembl:ENSMUSG00000062380 Vega:OTTMUSG00000027611
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    M(beta)3; M(beta)6; 3200002H15Rik
    Expression
    Biased expression in CNS E18 (RPKM 1032.5), whole brain E14.5 (RPKM 1029.6) and 5 other tissues See more
    Orthologs

    Genomic context

    See Tubb3 in Genome Data Viewer
    Location:
    8; 8 E1
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 8 NC_000074.6 (123411564..123422010)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 8 NC_000074.5 (125935464..125945910)

    Chromosome 8 - NC_000074.6Genomic Context describing neighboring genes Neighboring gene transcription factor 25 (basic helix-loop-helix) Neighboring gene melanocortin 1 receptor Neighboring gene differentially expressed in FDCP 8 Neighboring gene predicted gene, 39275

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from BioSystems

    • Diurnally Regulated Genes with Circadian Orthologs, organism-specific biosystem (from WikiPathways)
      Diurnally Regulated Genes with Circadian Orthologs, organism-specific biosystemMouse genes regulated in the diurnal (inferred from human) and compared with mouse genes that display circadian regulation in mouse heart and liver (Panda 2002, Storch 2002), and SCN (Panda 2002). Th...
    • Gap junction, organism-specific biosystem (from KEGG)
      Gap junction, organism-specific biosystemGap junctions contain intercellular channels that allow direct communication between the cytosolic compartments of adjacent cells. Each gap junction channel is formed by docking of two 'hemichannels'...
    • Gap junction, conserved biosystem (from KEGG)
      Gap junction, conserved biosystemGap junctions contain intercellular channels that allow direct communication between the cytosolic compartments of adjacent cells. Each gap junction channel is formed by docking of two 'hemichannels'...
    • Phagosome, organism-specific biosystem (from KEGG)
      Phagosome, organism-specific biosystemPhagocytosis is the process of taking in relatively large particles by a cell, and is a central mechanism in the tissue remodeling, inflammation, and defense against infectious agents. A phagosome is...
    • Phagosome, conserved biosystem (from KEGG)
      Phagosome, conserved biosystemPhagocytosis is the process of taking in relatively large particles by a cell, and is a central mechanism in the tissue remodeling, inflammation, and defense against infectious agents. A phagosome is...

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    GTP binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    GTPase activity IEA
    Inferred from Electronic Annotation
    more info
     
    nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
     
    peptide binding ISO
    Inferred from Sequence Orthology
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    structural constituent of cytoskeleton IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    Process Evidence Code Pubs
    axon guidance IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    axon guidance IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    axon guidance ISO
    Inferred from Sequence Orthology
    more info
     
    microtubule cytoskeleton organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    microtubule-based process IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    mitotic cell cycle IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    mitotic cell cycle ISO
    Inferred from Sequence Orthology
    more info
     
    neuron differentiation IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    neuron differentiation ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    axon IDA
    Inferred from Direct Assay
    more info
    PubMed 
    axon ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    cell periphery IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
     
    dendrite IDA
    Inferred from Direct Assay
    more info
    PubMed 
    microtubule IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    microtubule ISO
    Inferred from Sequence Orthology
    more info
     
    microtubule cytoskeleton IDA
    Inferred from Direct Assay
    more info
    PubMed 
    neuronal cell body IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    tubulin beta-3 chain
    Names
    betaIII-tubulin

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_023279.3NP_075768.1  tubulin beta-3 chain

      See identical proteins and their annotated locations for NP_075768.1

      Status: VALIDATED

      Source sequence(s)
      AK082942, BC031357, CK780733
      Consensus CDS
      CCDS22757.1
      UniProtKB/Swiss-Prot
      Q9ERD7
      Related
      ENSMUSP00000071134.3, OTTMUSP00000034531, ENSMUST00000071134.3
      Conserved Domains (1) summary
      PLN00220
      Location:1447
      PLN00220; tubulin beta chain; Provisional

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000074.6 Reference GRCm38.p4 C57BL/6J

      Range
      123411564..123422010
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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