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    FCGR2A Fc fragment of IgG receptor IIa [ Homo sapiens (human) ]

    Gene ID: 2212, updated on 26-Jul-2021

    Summary

    Official Symbol
    FCGR2Aprovided by HGNC
    Official Full Name
    Fc fragment of IgG receptor IIaprovided by HGNC
    Primary source
    HGNC:HGNC:3616
    See related
    Ensembl:ENSG00000143226 MIM:146790
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    CD32; FCG2; FcGR; CD32A; CDw32; FCGR2; IGFR2; FCGR2A1
    Summary
    This gene encodes one member of a family of immunoglobulin Fc receptor genes found on the surface of many immune response cells. The protein encoded by this gene is a cell surface receptor found on phagocytic cells such as macrophages and neutrophils, and is involved in the process of phagocytosis and clearing of immune complexes. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2008]
    Expression
    Broad expression in appendix (RPKM 39.7), placenta (RPKM 36.5) and 21 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See FCGR2A in Genome Data Viewer
    Location:
    1q23.3
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    109.20210514 current GRCh38.p13 (GCF_000001405.39) 1 NC_000001.11 (161505430..161524048)
    105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (161475247..161489619)

    Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105371473 Neighboring gene CRISPRi-validated cis-regulatory element chr1.9514 Neighboring gene tRNA-Asp (GTC) 10-1 Neighboring gene tRNA-Gly (anticodon GCC) 2-1 Neighboring gene heat shock protein family A (Hsp70) member 6 Neighboring gene tRNA-Leu (anticodon CAG) 1-6

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Phenotypes

    Associated conditions

    Description Tests
    A genome-wide association study identifies three new susceptibility loci for ulcerative colitis in the Japanese population.
    GeneReviews: Not available
    Cystic fibrosis Compare labs
    Genetic predictors of risk and resilience in psychiatric disorders: a cross-disorder genome-wide association study of functional impairment in major depressive disorder, bipolar disorder, and schizophrenia.
    GeneReviews: Not available
    Genetics of rheumatoid arthritis contributes to biology and drug discovery.
    GeneReviews: Not available
    Genome-wide association identifies multiple ulcerative colitis susceptibility loci.
    GeneReviews: Not available
    Genome-wide association study identifies FCGR2A as a susceptibility locus for Kawasaki disease.
    GeneReviews: Not available
    Genome-wide association study identifies multiple loci influencing human serum metabolite levels.
    GeneReviews: Not available
    GWAS identifies novel SLE susceptibility genes and explains the association of the HLA region.
    GeneReviews: Not available
    Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease.
    GeneReviews: Not available
    Identification of genetic loci associated with Helicobacter pylori serologic status.
    GeneReviews: Not available
    Meta-analysis identifies 29 additional ulcerative colitis risk loci, increasing the number of confirmed associations to 47.
    GeneReviews: Not available
    Susceptibility to malaria
    MedGen: C1970028 OMIM: 611162 GeneReviews: Not available
    Compare labs
    Systemic lupus erythematosus
    MedGen: C0024141 OMIM: 152700 GeneReviews: Not available
    Compare labs

    HIV-1 interactions

    Protein interactions

    Protein Gene Interaction Pubs
    Envelope surface glycoprotein gp120 env IgG2 and IgG4 bind more poorly to enzymatically deglycosylated recombinant gp120 (rgp120) than to unchanged rgp120 PubMed
    Nef nef HIV-1 Nef downregulates Fc-gamma Receptor II in human monocytes/macrophages PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • MGC23887, MGC30032

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables IgG binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables transmembrane signaling receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in cell surface receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in immune system process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in regulation of immune response IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in Golgi apparatus IDA
    Inferred from Direct Assay
    more info
     
    is_active_in integral component of plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
     
    located_in plasma membrane TAS
    Traceable Author Statement
    more info
     
    located_in secretory granule membrane TAS
    Traceable Author Statement
    more info
     

    General protein information

    Preferred Names
    low affinity immunoglobulin gamma Fc region receptor II-a
    Names
    Fc fragment of IgG, low affinity IIa, receptor (CD32)
    Fc gamma receptor RIIa3
    Immunoglobulin G Fc receptor II
    fc-gamma-RIIa
    fcRII-a
    igG Fc receptor II-a

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_012066.2 RefSeqGene

      Range
      5043..19415
      Download
      GenBank, FASTA, Sequence Viewer (Graphics), LRG_1109

    mRNA and Protein(s)

    1. NM_001136219.3NP_001129691.1  low affinity immunoglobulin gamma Fc region receptor II-a isoform 1 precursor

      See identical proteins and their annotated locations for NP_001129691.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AA634082, AK315225, AL590385
      Consensus CDS
      CCDS44264.1
      UniProtKB/Swiss-Prot
      P12318
      Related
      ENSP00000271450.6, ENST00000271450.12
      Conserved Domains (3) summary
      cd05752
      Location:41119
      Ig1_FcgammaR_like; Frst immunoglobulin (Ig)-like domain of Fcgamma-receptors (FcgammaRs) and similar proteins
      cd05753
      Location:123205
      Ig2_FcgammaR_like; Second immunoglobulin (Ig)-like domain of Fcgamma-receptors (FcgammaRs) and similar proteins
      smart00410
      Location:129205
      IG_like; Immunoglobulin like
    2. NM_001375296.1NP_001362225.1  low affinity immunoglobulin gamma Fc region receptor II-a isoform 3 precursor

      Status: REVIEWED

      Source sequence(s)
      AL590385, BC019931, BX379627
      Conserved Domains (2) summary
      cd05752
      Location:41119
      Ig1_FcgammaR_like; Frst immunoglobulin (Ig)-like domain of Fcgamma-receptors (FcgammaRs) and similar proteins
      cd05753
      Location:123205
      Ig2_FcgammaR_like; Second immunoglobulin (Ig)-like domain of Fcgamma-receptors (FcgammaRs) and similar proteins
    3. NM_001375297.1NP_001362226.1  low affinity immunoglobulin gamma Fc region receptor II-a isoform 4 precursor

      Status: REVIEWED

      Source sequence(s)
      AL590385
      Conserved Domains (2) summary
      cd05752
      Location:40118
      Ig1_FcgammaR_like; Frst immunoglobulin (Ig)-like domain of Fcgamma-receptors (FcgammaRs) and similar proteins
      cd05753
      Location:122204
      Ig2_FcgammaR_like; Second immunoglobulin (Ig)-like domain of Fcgamma-receptors (FcgammaRs) and similar proteins
    4. NM_021642.5NP_067674.2  low affinity immunoglobulin gamma Fc region receptor II-a isoform 2 precursor

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) uses an alternate in-frame splice site in the 5' coding region, compared to variant 1, resulting in a shorter protein (isoform 2), compared to isoform 1.
      Source sequence(s)
      AL590385, BC019931
      Consensus CDS
      CCDS30922.1
      UniProtKB/Swiss-Prot
      P12318
      Related
      ENSP00000356949.4, ENST00000367972.8
      Conserved Domains (3) summary
      cd05752
      Location:40118
      Ig1_FcgammaR_like; Frst immunoglobulin (Ig)-like domain of Fcgamma-receptors (FcgammaRs) and similar proteins
      cd05753
      Location:122204
      Ig2_FcgammaR_like; Second immunoglobulin (Ig)-like domain of Fcgamma-receptors (FcgammaRs) and similar proteins
      smart00410
      Location:128204
      IG_like; Immunoglobulin like

    RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p13 Primary Assembly

    Genomic

    1. NC_000001.11 Reference GRCh38.p13 Primary Assembly

      Range
      161505430..161524048
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017000664.1XP_016856153.1  low affinity immunoglobulin gamma Fc region receptor II-a isoform X3

    2. XM_017000665.1XP_016856154.1  low affinity immunoglobulin gamma Fc region receptor II-a isoform X3

    3. XM_011509287.2XP_011507589.1  low affinity immunoglobulin gamma Fc region receptor II-a isoform X1

      Conserved Domains (3) summary
      cd05752
      Location:41119
      Ig1_FcgammaR_like; Frst immunoglobulin (Ig)-like domain of Fcgamma-receptors (FcgammaRs) and similar proteins
      cd05753
      Location:123205
      Ig2_FcgammaR_like; Second immunoglobulin (Ig)-like domain of Fcgamma-receptors (FcgammaRs) and similar proteins
      smart00410
      Location:129205
      IG_like; Immunoglobulin like
    4. XM_017000666.1XP_016856155.1  low affinity immunoglobulin gamma Fc region receptor II-a isoform X4

      Conserved Domains (3) summary
      cd05752
      Location:41119
      Ig1_FcgammaR_like; Frst immunoglobulin (Ig)-like domain of Fcgamma-receptors (FcgammaRs) and similar proteins
      cd05753
      Location:123205
      Ig2_FcgammaR_like; Second immunoglobulin (Ig)-like domain of Fcgamma-receptors (FcgammaRs) and similar proteins
      smart00410
      Location:129205
      IG_like; Immunoglobulin like
    5. XM_011509290.2XP_011507592.1  low affinity immunoglobulin gamma Fc region receptor II-a isoform X5

      Conserved Domains (3) summary
      cd05752
      Location:41119
      Ig1_FcgammaR_like; Frst immunoglobulin (Ig)-like domain of Fcgamma-receptors (FcgammaRs) and similar proteins
      cd05753
      Location:123205
      Ig2_FcgammaR_like; Second immunoglobulin (Ig)-like domain of Fcgamma-receptors (FcgammaRs) and similar proteins
      smart00410
      Location:129205
      IG_like; Immunoglobulin like
    6. XM_011509291.1XP_011507593.1  low affinity immunoglobulin gamma Fc region receptor II-a isoform X8

      Conserved Domains (3) summary
      cd05752
      Location:41119
      Ig1_FcgammaR_like; Frst immunoglobulin (Ig)-like domain of Fcgamma-receptors (FcgammaRs) and similar proteins
      cd05753
      Location:123205
      Ig2_FcgammaR_like; Second immunoglobulin (Ig)-like domain of Fcgamma-receptors (FcgammaRs) and similar proteins
      smart00410
      Location:129205
      IG_like; Immunoglobulin like
    7. XM_017000663.2XP_016856152.1  low affinity immunoglobulin gamma Fc region receptor II-a isoform X2

      Conserved Domains (3) summary
      cd05752
      Location:40118
      Ig1_FcgammaR_like; Frst immunoglobulin (Ig)-like domain of Fcgamma-receptors (FcgammaRs) and similar proteins
      cd05753
      Location:122204
      Ig2_FcgammaR_like; Second immunoglobulin (Ig)-like domain of Fcgamma-receptors (FcgammaRs) and similar proteins
      smart00410
      Location:128204
      IG_like; Immunoglobulin like
    8. XM_024454040.1XP_024309808.1  low affinity immunoglobulin gamma Fc region receptor II-a isoform X9

      Conserved Domains (1) summary
      cd05753
      Location:166
      Ig2_FcgammaR_like; Second immunoglobulin (Ig)-like domain of Fcgamma-receptors (FcgammaRs) and similar proteins
    9. XM_024454041.1XP_024309809.1  low affinity immunoglobulin gamma Fc region receptor II-a isoform X10

      Conserved Domains (1) summary
      cd05753
      Location:166
      Ig2_FcgammaR_like; Second immunoglobulin (Ig)-like domain of Fcgamma-receptors (FcgammaRs) and similar proteins

    RNA

    1. XR_001737042.1 RNA Sequence

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