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    Tst thiosulfate sulfurtransferase, mitochondrial [ Mus musculus (house mouse) ]

    Gene ID: 22117, updated on 18-Sep-2024

    Summary

    Official Symbol
    Tstprovided by MGI
    Official Full Name
    thiosulfate sulfurtransferase, mitochondrialprovided by MGI
    Primary source
    MGI:MGI:98852
    See related
    Ensembl:ENSMUSG00000044986 AllianceGenome:MGI:98852
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    rhodanese
    Summary
    Predicted to enable 5S rRNA binding activity and thiosulfate sulfurtransferase activity. Predicted to be involved in epithelial cell differentiation; rRNA import into mitochondrion; and transsulfuration. Located in mitochondrial inner membrane. Is expressed in several structures, including alimentary system; genitourinary system; nervous system; respiratory system; and sensory organ. Orthologous to human TST (thiosulfate sulfurtransferase). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Broad expression in liver adult (RPKM 153.9), adrenal adult (RPKM 109.2) and 17 other tissues See more
    Orthologs
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    Genomic context

    See Tst in Genome Data Viewer
    Location:
    15 E1; 15 37.47 cM
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 15 NC_000081.7 (78283756..78290065, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 15 NC_000081.6 (78399556..78405865, complement)

    Chromosome 15 - NC_000081.7Genomic Context describing neighboring genes Neighboring gene colony stimulating factor 2 receptor, beta, low-affinity (granulocyte-macrophage) Neighboring gene microRNA 7676-2 Neighboring gene ciliary microtubule inner protein 4 Neighboring gene STARR-seq mESC enhancer starr_39143 Neighboring gene predicted gene, 52185 Neighboring gene mercaptopyruvate sulfurtransferase Neighboring gene predicted gene, 36644 Neighboring gene predicted gene, 41355

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 
    • Targeted (2) 

    Pathways from PubChem

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables 3-mercaptopyruvate sulfurtransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables 5S rRNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables 5S rRNA binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables thiosulfate sulfurtransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables thiosulfate sulfurtransferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    involved_in epithelial cell differentiation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in epithelial cell differentiation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in rRNA import into mitochondrion ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in rRNA import into mitochondrion ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in rRNA transport ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in rRNA transport ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Component Evidence Code Pubs
    located_in mitochondrial inner membrane HDA PubMed 
    located_in mitochondrial matrix IEA
    Inferred from Electronic Annotation
    more info
     
    located_in mitochondrion HDA PubMed 
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    thiosulfate sulfurtransferase
    NP_033463.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_009437.5NP_033463.1  thiosulfate sulfurtransferase

      See identical proteins and their annotated locations for NP_033463.1

      Status: VALIDATED

      Source sequence(s)
      AL583893
      Consensus CDS
      CCDS27614.1
      UniProtKB/Swiss-Prot
      P52196
      UniProtKB/TrEMBL
      Q545S0
      Related
      ENSMUSP00000055743.8, ENSMUST00000058659.9
      Conserved Domains (3) summary
      COG2897
      Location:10279
      SseA; 3-mercaptopyruvate sulfurtransferase SseA, contains two rhodanese domains [Inorganic ion transport and metabolism]
      cd01445
      Location:11136
      TST_Repeats; Thiosulfate sulfurtransferases (TST) contain 2 copies of the Rhodanese Homology Domain. Only the second repeat contains the catalytically active Cys residue. The role of the 1st repeat is uncertain, but believed to be involved in protein interaction. ...
      cd01449
      Location:163281
      TST_Repeat_2; Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue.

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000081.7 Reference GRCm39 C57BL/6J

      Range
      78283756..78290065 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)