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    ARL5B ADP ribosylation factor like GTPase 5B [ Homo sapiens (human) ]

    Gene ID: 221079, updated on 5-Mar-2024

    Summary

    Official Symbol
    ARL5Bprovided by HGNC
    Official Full Name
    ADP ribosylation factor like GTPase 5Bprovided by HGNC
    Primary source
    HGNC:HGNC:23052
    See related
    Ensembl:ENSG00000165997 MIM:608909; AllianceGenome:HGNC:23052
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    ARL8
    Summary
    ARL5B (ARL8) belongs to a family of proteins that are structurally similar to ADP-ribosylation factors (ARFs; see MIM 103180). ARLs and ARFs are part of the RAS superfamily of regulatory GTPases.[supplied by OMIM, Nov 2010]
    Expression
    Ubiquitous expression in adrenal (RPKM 13.8), gall bladder (RPKM 10.5) and 25 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See ARL5B in Genome Data Viewer
    Location:
    10p12.31
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 10 NC_000010.11 (18659431..18681639)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 10 NC_060934.1 (18678534..18700749)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 10 NC_000010.10 (18948360..18970568)

    Chromosome 10 - NC_000010.11Genomic Context describing neighboring genes Neighboring gene calcium voltage-gated channel auxiliary subunit beta 2 Neighboring gene uncharacterized LOC124902386 Neighboring gene uncharacterized LOC124902387 Neighboring gene NANOG hESC enhancer GRCh37_chr10:18841481-18841982 Neighboring gene NOP2/Sun RNA methyltransferase 6 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3113 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3114 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3115 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3116 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2184 Neighboring gene uncharacterized LOC105376440 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr10:19041189-19042388 Neighboring gene AIFM1 pseudogene 1 Neighboring gene MPRA-validated peak892 silencer Neighboring gene uncharacterized LOC107984180

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Phenotypes

    EBI GWAS Catalog

    Description
    GWAS for discovery and replication of genetic loci associated with sudden cardiac arrest in patients with coronary artery disease.
    EBI GWAS Catalog

    HIV-1 interactions

    Protein interactions

    Protein Gene Interaction Pubs
    Nef nef Genome-wide shRNA screening identifies ARL5B, which is required for HIV-1 Nef-induced downregulation of CD4 in HeLa CD4+ cells PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables GTP binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables GTP binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables GTPase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in intracellular protein transport IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in protein localization to Golgi membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in protein localization to Golgi membrane IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in vesicle-mediated transport IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    is_active_in trans-Golgi network IBA
    Inferred from Biological aspect of Ancestor
    more info
     

    General protein information

    Preferred Names
    ADP-ribosylation factor-like protein 5B
    Names
    ADP-ribosylation factor-like 5B
    ADP-ribosylation factor-like 8
    ADP-ribosylation factor-like protein 8
    ADP-ribosylation-like factor 8

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_178815.5NP_848930.1  ADP-ribosylation factor-like protein 5B

      See identical proteins and their annotated locations for NP_848930.1

      Status: VALIDATED

      Source sequence(s)
      AL133611, AL512641
      Consensus CDS
      CCDS7131.1
      UniProtKB/Swiss-Prot
      Q96KC2
      UniProtKB/TrEMBL
      B0YIW9
      Related
      ENSP00000366487.3, ENST00000377275.4
      Conserved Domains (1) summary
      cd04153
      Location:3175
      Arl5_Arl8; Arf-like 5 (Arl5) and 8 (Arl8) GTPases

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000010.11 Reference GRCh38.p14 Primary Assembly

      Range
      18659431..18681639
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005252400.2XP_005252457.1  ADP-ribosylation factor-like protein 5B isoform X1

      See identical proteins and their annotated locations for XP_005252457.1

      Conserved Domains (2) summary
      smart00178
      Location:8148
      SAR; Sar1p-like members of the Ras-family of small GTPases
      cl21455
      Location:3147
      P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
    2. XM_005252401.5XP_005252458.1  ADP-ribosylation factor-like protein 5B isoform X2

      See identical proteins and their annotated locations for XP_005252458.1

      Conserved Domains (1) summary
      cl38936
      Location:1138
      P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060934.1 Alternate T2T-CHM13v2.0

      Range
      18678534..18700749
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054365129.1XP_054221104.1  ADP-ribosylation factor-like protein 5B isoform X1

    2. XM_054365130.1XP_054221105.1  ADP-ribosylation factor-like protein 5B isoform X2