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    Tsg101 tumor susceptibility gene 101 [ Mus musculus (house mouse) ]

    Gene ID: 22088, updated on 12-Aug-2018

    Summary

    Official Symbol
    Tsg101provided by MGI
    Official Full Name
    tumor susceptibility gene 101provided by MGI
    Primary source
    MGI:MGI:106581
    See related
    Ensembl:ENSMUSG00000014402 Vega:OTTMUSG00000024345
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    CC2; AI255943
    Expression
    Ubiquitous expression in CNS E11.5 (RPKM 29.9), CNS E14 (RPKM 28.1) and 28 other tissues See more
    Orthologs

    Genomic context

    See Tsg101 in Genome Data Viewer
    Location:
    7; 7 B3
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 7 NC_000073.6 (46889027..46919971, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 7 NC_000073.5 (54144397..54175300, complement)

    Chromosome 7 - NC_000073.6Genomic Context describing neighboring genes Neighboring gene lactate dehydrogenase A Neighboring gene predicted gene, 39011 Neighboring gene lactate dehydrogenase C Neighboring gene UEV and lactate/malate dehyrogenase domains Neighboring gene predicted gene, 39012 Neighboring gene thymosin, beta 10 pseudogene

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from BioSystems

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    calcium-dependent protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    nuclear receptor transcription coactivator activity ISO
    Inferred from Sequence Orthology
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein homodimerization activity ISO
    Inferred from Sequence Orthology
    more info
     
    protein-containing complex binding ISO
    Inferred from Sequence Orthology
    more info
     
    transcription corepressor activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    ubiquitin binding ISO
    Inferred from Sequence Orthology
    more info
     
    ubiquitin protein ligase binding ISO
    Inferred from Sequence Orthology
    more info
     
    virion binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    cell cycle IEA
    Inferred from Electronic Annotation
    more info
     
    cell cycle arrest IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cell differentiation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cell division IEA
    Inferred from Electronic Annotation
    more info
     
    cellular protein modification process IEA
    Inferred from Electronic Annotation
    more info
     
    endosome to lysosome transport ISO
    Inferred from Sequence Orthology
    more info
     
    exosomal secretion IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    extracellular transport ISO
    Inferred from Sequence Orthology
    more info
     
    keratinocyte differentiation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    negative regulation of cell proliferation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    negative regulation of epidermal growth factor receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of epidermal growth factor-activated receptor activity ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of transcription, DNA-templated IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of exosomal secretion ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of ubiquitin-dependent endocytosis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of viral budding via host ESCRT complex ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of viral process ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of viral release from host cell ISO
    Inferred from Sequence Orthology
    more info
     
    protein monoubiquitination ISO
    Inferred from Sequence Orthology
    more info
     
    protein transport IEA
    Inferred from Electronic Annotation
    more info
     
    regulation of MAP kinase activity ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of cell growth IDA
    Inferred from Direct Assay
    more info
    PubMed 
    regulation of extracellular exosome assembly ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of growth IEA
    Inferred from Electronic Annotation
    more info
     
    regulation of viral budding via host ESCRT complex ISO
    Inferred from Sequence Orthology
    more info
     
    ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway ISO
    Inferred from Sequence Orthology
    more info
     
    viral budding IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    viral budding ISO
    Inferred from Sequence Orthology
    more info
     
    viral process IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    ESCRT I complex ISO
    Inferred from Sequence Orthology
    more info
     
    ESCRT I complex NAS
    Non-traceable Author Statement
    more info
    PubMed 
    cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
     
    cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    early endosome ISO
    Inferred from Sequence Orthology
    more info
     
    endosome ISO
    Inferred from Sequence Orthology
    more info
     
    endosome membrane ISO
    Inferred from Sequence Orthology
    more info
     
    extracellular exosome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    extracellular exosome ISO
    Inferred from Sequence Orthology
    more info
     
    late endosome ISO
    Inferred from Sequence Orthology
    more info
     
    membrane IEA
    Inferred from Electronic Annotation
    more info
     
    nucleolus ISO
    Inferred from Sequence Orthology
    more info
     
    nucleus IC
    Inferred by Curator
    more info
    PubMed 
    nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    tumor susceptibility gene 101 protein
    Names
    ESCRT-I complex subunit TSG101

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001348088.1NP_001335017.1  tumor susceptibility gene 101 protein isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks two alternate exons in the coding region compared to variant 1. The encoded isoform (2) is shorter compared to isoform 1.
      Source sequence(s)
      AC090123
      Conserved Domains (3) summary
      pfam05743
      Location:21139
      UEV; UEV domain
      pfam09454
      Location:264323
      Vps23_core; Vps23 core domain
      cl25732
      Location:189331
      SMC_N; RecF/RecN/SMC N terminal domain
    2. NM_001348089.1NP_001335018.1  tumor susceptibility gene 101 protein isoform 3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) uses an alternate splice site in the 5' region and uses a downstream start codon compared to variant 1. It encodes isoform 3 which has a shorter N-terminus compared to isoform 1.
      Source sequence(s)
      AC090123
      Conserved Domains (3) summary
      pfam09454
      Location:223282
      Vps23_core; Vps23 core domain
      cl00154
      Location:145
      UBCc; Ubiquitin-conjugating enzyme E2, catalytic (UBCc) domain. This is part of the ubiquitin-mediated protein degradation pathway in which a thiol-ester linkage forms between a conserved cysteine and the C-terminus of ubiquitin and complexes with ubiquitin ...
      cl25732
      Location:148290
      SMC_N; RecF/RecN/SMC N terminal domain
    3. NM_021884.4NP_068684.1  tumor susceptibility gene 101 protein isoform 1

      See identical proteins and their annotated locations for NP_068684.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
      Source sequence(s)
      AC090123, AK146602, BY250758, CB183613
      Consensus CDS
      CCDS21291.1
      UniProtKB/Swiss-Prot
      Q61187
      UniProtKB/TrEMBL
      Q3UCW0
      Related
      ENSMUSP00000014546.8, OTTMUSP00000029024, ENSMUST00000014546.14, OTTMUST00000059640
      Conserved Domains (3) summary
      pfam05743
      Location:21139
      UEV; UEV domain
      pfam09454
      Location:317376
      Vps23_core; Vps23 core domain
      cl25732
      Location:242384
      SMC_N; RecF/RecN/SMC N terminal domain

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000073.6 Reference GRCm38.p4 C57BL/6J

      Range
      46889027..46919971 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006540789.3XP_006540852.1  tumor susceptibility gene 101 protein isoform X2

      Conserved Domains (3) summary
      pfam05743
      Location:21139
      UEV; UEV domain
      pfam09454
      Location:264323
      Vps23_core; Vps23 core domain
      cl25732
      Location:189331
      SMC_N; RecF/RecN/SMC N terminal domain
    2. XM_006540788.3XP_006540851.1  tumor susceptibility gene 101 protein isoform X1

      Conserved Domains (3) summary
      pfam05743
      Location:21104
      UEV; UEV domain
      pfam07798
      Location:202258
      DUF1640; Protein of unknown function (DUF1640)
      pfam09454
      Location:282337
      Vps23_core; Vps23 core domain
    3. XM_006540790.3XP_006540853.1  tumor susceptibility gene 101 protein isoform X3

      Conserved Domains (3) summary
      pfam09454
      Location:223282
      Vps23_core; Vps23 core domain
      cl00154
      Location:145
      UBCc; Ubiquitin-conjugating enzyme E2, catalytic (UBCc) domain. This is part of the ubiquitin-mediated protein degradation pathway in which a thiol-ester linkage forms between a conserved cysteine and the C-terminus of ubiquitin and complexes with ubiquitin ...
      cl25732
      Location:148290
      SMC_N; RecF/RecN/SMC N terminal domain

    RNA

    1. XR_391333.3 RNA Sequence

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