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    Ctr9 CTR9 homolog, Paf1/RNA polymerase II complex component [ Mus musculus (house mouse) ]

    Gene ID: 22083, updated on 31-Jan-2019

    Summary

    Official Symbol
    Ctr9provided by MGI
    Official Full Name
    CTR9 homolog, Paf1/RNA polymerase II complex componentprovided by MGI
    Primary source
    MGI:MGI:109345
    See related
    Ensembl:ENSMUSG00000005609
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Tsp; Tsbp; Sh2bp1; AA409336; mKIAA0155
    Expression
    Ubiquitous expression in placenta adult (RPKM 19.3), CNS E11.5 (RPKM 16.4) and 27 other tissues See more
    Orthologs

    Genomic context

    See Ctr9 in Genome Data Viewer
    Location:
    7 E3; 7 57.98 cM
    Exon count:
    25
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 7 NC_000073.6 (111028951..111056377)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 7 NC_000073.5 (118172465..118199891)

    Chromosome 7 - NC_000073.6Genomic Context describing neighboring genes Neighboring gene lymphatic vessel endothelial hyaluronan receptor 1 Neighboring gene MRV integration site 1 Neighboring gene predicted gene 16336 Neighboring gene eukaryotic translation initiation factor 4, gamma 2 Neighboring gene RIKEN cDNA 1700012D14 gene

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (2) 

    Pathways from BioSystems

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • KIAA0155

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    RNA polymerase II complex binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    SH2 domain binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    contributes_to protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    JAK-STAT cascade IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Wnt signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    blastocyst growth IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    blastocyst growth IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    blastocyst hatching IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    cellular response to lipopolysaccharide IDA
    Inferred from Direct Assay
    more info
    PubMed 
    endodermal cell fate commitment IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    histone H2B ubiquitination ISO
    Inferred from Sequence Orthology
    more info
     
    histone H3-K4 trimethylation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    histone H3-K4 trimethylation ISO
    Inferred from Sequence Orthology
    more info
     
    histone modification IEA
    Inferred from Electronic Annotation
    more info
     
    histone monoubiquitination ISO
    Inferred from Sequence Orthology
    more info
     
    inner cell mass cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    interleukin-6-mediated signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of mRNA polyadenylation ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of myeloid cell differentiation ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of transcription by RNA polymerase II IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of histone H2B ubiquitination ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of histone H3-K4 methylation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of histone H3-K4 methylation ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of histone H3-K79 methylation ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of transcription elongation from RNA polymerase II promoter ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of genetic imprinting IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of histone H3-K4 methylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    regulation of transcription, DNA-templated IEA
    Inferred from Electronic Annotation
    more info
     
    stem cell population maintenance IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    stem cell population maintenance ISO
    Inferred from Sequence Orthology
    more info
     
    trophectodermal cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    Cdc73/Paf1 complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    colocalizes_with Cdc73/Paf1 complex IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Cdc73/Paf1 complex ISO
    Inferred from Sequence Orthology
    more info
     
    nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    transcriptionally active chromatin IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    RNA polymerase-associated protein CTR9 homolog
    Names
    Ctr9, Paf1/RNA polymerase II complex component, homolog
    SH2 domain binding protein 1 (tetratricopeptide repeat containing)
    SH2 domain-binding protein 1
    TPR-containing, SH2-binding phosphoprotein of 150 kDa
    p150TSP
    tetratricopeptide repeat-containing, SH2-binding phosphoprotein of 150 kDa

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_009431.2NP_033457.2  RNA polymerase-associated protein CTR9 homolog

      See identical proteins and their annotated locations for NP_033457.2

      Status: VALIDATED

      Source sequence(s)
      AI841408, BC024749, BY012072, L49502
      Consensus CDS
      CCDS21750.1
      UniProtKB/Swiss-Prot
      Q62018
      UniProtKB/TrEMBL
      Q05CJ7
      Related
      ENSMUSP00000005749.5, ENSMUST00000005749.5
      Conserved Domains (6) summary
      PHA02664
      Location:10511154
      PHA02664; hypothetical protein; Provisional
      TIGR02795
      Location:310414
      tol_pal_ybgF; tol-pal system protein YbgF
      sd00006
      Location:501525
      TPR; TPR repeat [structural motif]
      pfam13414
      Location:165228
      TPR_11; TPR repeat
      pfam13424
      Location:498563
      TPR_12; Tetratricopeptide repeat
      pfam14797
      Location:10391159
      SEEEED; Serine-rich region of AP3B1, clathrin-adaptor complex

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000073.6 Reference GRCm38.p4 C57BL/6J

      Range
      111028951..111056377
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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