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    Ctr9 CTR9 homolog, Paf1/RNA polymerase II complex component [ Mus musculus (house mouse) ]

    Gene ID: 22083, updated on 23-Jun-2021

    Summary

    Official Symbol
    Ctr9provided by MGI
    Official Full Name
    CTR9 homolog, Paf1/RNA polymerase II complex componentprovided by MGI
    Primary source
    MGI:MGI:109345
    See related
    Ensembl:ENSMUSG00000005609
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    T; Ts; Tsp; Sh2b; Tsbp; Sh2bp1; AA409336; mKIAA0155
    Expression
    Ubiquitous expression in placenta adult (RPKM 19.3), CNS E11.5 (RPKM 16.4) and 27 other tissues See more
    Orthologs
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    Genomic context

    See Ctr9 in Genome Data Viewer
    Location:
    7 E3; 7 57.98 cM
    Exon count:
    25
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (110628158..110655584)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (111028951..111056377)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 7 NC_000073.5 (118172465..118199891)

    Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene lymphatic vessel endothelial hyaluronan receptor 1 Neighboring gene inositol 1,4,5-triphosphate receptor associated 1 Neighboring gene predicted gene 16336 Neighboring gene eukaryotic translation initiation factor 4, gamma 2 Neighboring gene predicted gene, 23262 Neighboring gene RIKEN cDNA 1700012D14 gene

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (2) 

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • KIAA0155

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables RNA polymerase II complex binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables SH2 domain binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    contributes_to protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within Wnt signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within blastocyst growth IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    acts_upstream_of_or_within blastocyst growth IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within blastocyst hatching IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in cellular response to lipopolysaccharide IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in endodermal cell fate commitment IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in histone H2B ubiquitination ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in histone H3-K4 trimethylation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in histone H3-K4 trimethylation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in histone modification IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in histone monoubiquitination ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within inner cell mass cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in interleukin-6-mediated signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of mRNA polyadenylation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of myeloid cell differentiation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of transcription by RNA polymerase II IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of histone H2B ubiquitination ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of histone H3-K4 methylation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of histone H3-K4 methylation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of histone H3-K79 methylation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in receptor signaling pathway via JAK-STAT IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within regulation of genetic imprinting IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in regulation of histone H3-K4 methylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in regulation of transcription, DNA-templated IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in stem cell population maintenance IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in stem cell population maintenance ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in transcription elongation from RNA polymerase II promoter ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within trophectodermal cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    part_of Cdc73/Paf1 complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    part_of Cdc73/Paf1 complex IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    part_of Cdc73/Paf1 complex ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in transcriptionally active chromatin IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    RNA polymerase-associated protein CTR9 homolog
    Names
    Ctr9, Paf1/RNA polymerase II complex component, homolog
    SH2 domain binding protein 1 (tetratricopeptide repeat containing)
    SH2 domain-binding protein 1
    TPR-containing, SH2-binding phosphoprotein of 150 kDa
    p150TSP
    tetratricopeptide repeat-containing, SH2-binding phosphoprotein of 150 kDa

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_009431.2NP_033457.2  RNA polymerase-associated protein CTR9 homolog

      See identical proteins and their annotated locations for NP_033457.2

      Status: VALIDATED

      Source sequence(s)
      AI841408, BC024749, BY012072, L49502
      Consensus CDS
      CCDS21750.1
      UniProtKB/Swiss-Prot
      Q62018
      UniProtKB/TrEMBL
      Q05CJ7
      Related
      ENSMUSP00000005749.6, ENSMUST00000005749.6
      Conserved Domains (6) summary
      PHA02664
      Location:10511154
      PHA02664; hypothetical protein; Provisional
      TIGR02795
      Location:310414
      tol_pal_ybgF; tol-pal system protein YbgF
      sd00006
      Location:501525
      TPR; TPR repeat [structural motif]
      pfam13414
      Location:165228
      TPR_11; TPR repeat
      pfam13424
      Location:498563
      TPR_12; Tetratricopeptide repeat
      pfam14797
      Location:10391159
      SEEEED; Serine-rich region of AP3B1, clathrin-adaptor complex

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000073.7 Reference GRCm39 C57BL/6J

      Range
      110628158..110655584
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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