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    Hsp90b1 heat shock protein 90, beta (Grp94), member 1 [ Mus musculus (house mouse) ]

    Gene ID: 22027, updated on 3-Oct-2018

    Summary

    Official Symbol
    Hsp90b1provided by MGI
    Official Full Name
    heat shock protein 90, beta (Grp94), member 1provided by MGI
    Primary source
    MGI:MGI:98817
    See related
    Ensembl:ENSMUSG00000020048 Vega:OTTMUSG00000020538
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    TA-3; Tra1; gp96; ERp99; GRP94; Targ2; Tra-1; endoplasmin
    Expression
    Broad expression in placenta adult (RPKM 303.0), CNS E11.5 (RPKM 168.9) and 20 other tissues See more
    Orthologs

    Genomic context

    See Hsp90b1 in Genome Data Viewer
    Location:
    10 C1; 10 43.05 cM
    Exon count:
    18
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 10 NC_000076.6 (86690841..86705444, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 10 NC_000076.5 (86153586..86168189, complement)

    Chromosome 10 - NC_000076.6Genomic Context describing neighboring genes Neighboring gene predicted gene 5174 Neighboring gene RIKEN cDNA 1810014B01 gene Neighboring gene tetratricopeptide repeat domain 41 Neighboring gene fatty acid binding protein 3, muscle and heart, pseudogene 1 Neighboring gene 5'-nucleotidase domain containing 3

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from BioSystems

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    RNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    low-density lipoprotein particle receptor binding ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
     
    protein binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein phosphatase binding ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    unfolded protein binding IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    actin rod assembly ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    cellular response to ATP ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    negative regulation of apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    protein folding IEA
    Inferred from Electronic Annotation
    more info
     
    regulation of phosphoprotein phosphatase activity ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    response to hypoxia IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    response to hypoxia ISO
    Inferred from Sequence Orthology
    more info
     
    retrograde protein transport, ER to cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    ubiquitin-dependent ERAD pathway ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    endoplasmic reticulum IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    endoplasmic reticulum IDA
    Inferred from Direct Assay
    more info
    PubMed 
    endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
     
    endoplasmic reticulum chaperone complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    endoplasmic reticulum lumen ISO
    Inferred from Sequence Orthology
    more info
     
    endoplasmic reticulum membrane ISO
    Inferred from Sequence Orthology
    more info
     
    midbody ISO
    Inferred from Sequence Orthology
    more info
     
    perinuclear region of cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    perinuclear region of cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    protein-containing complex ISO
    Inferred from Sequence Orthology
    more info
     
    smooth endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    endoplasmin
    Names
    94 kDa glucose-regulated protein
    endoplasmic reticulum resident protein 99
    heat shock protein 90 kDa beta member 1
    polymorphic tumor rejection antigen 1
    transforming growth factor alpha regulated gene 2
    tumor rejection antigen (gp96) 1
    tumor rejection antigen gp96

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_011631.1NP_035761.1  endoplasmin precursor

      See identical proteins and their annotated locations for NP_035761.1

      Status: PROVISIONAL

      Source sequence(s)
      J03297
      Consensus CDS
      CCDS36019.1
      UniProtKB/Swiss-Prot
      P08113
      UniProtKB/TrEMBL
      Q3UAD6
      Related
      ENSMUSP00000020238.7, OTTMUSP00000022393, ENSMUST00000020238.13, OTTMUST00000048697
      Conserved Domains (3) summary
      smart00387
      Location:96254
      HATPase_c; Histidine kinase-like ATPases
      PRK05218
      Location:74746
      PRK05218; heat shock protein 90; Provisional
      pfam00183
      Location:257783
      HSP90; Hsp90 protein

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000076.6 Reference GRCm38.p4 C57BL/6J

      Range
      86690841..86705444 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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