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    Tpp2 tripeptidyl peptidase II [ Mus musculus (house mouse) ]

    Gene ID: 22019, updated on 8-Jul-2021

    Summary

    Official Symbol
    Tpp2provided by MGI
    Official Full Name
    tripeptidyl peptidase IIprovided by MGI
    Primary source
    MGI:MGI:102724
    See related
    Ensembl:ENSMUSG00000041763
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    T; TPP-2; TppII
    Expression
    Ubiquitous expression in testis adult (RPKM 13.0), placenta adult (RPKM 12.4) and 27 other tissues See more
    Orthologs
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    Genomic context

    See Tpp2 in Genome Data Viewer
    Location:
    1 C1.1; 1 23.5 cM
    Exon count:
    30
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (43973130..44042160)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (43933970..44003000)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 1 NC_000067.5 (43990852..44059816)

    Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene DnaJ (Hsp40) homolog, subfamily C, member 27 pseudogene Neighboring gene predicted gene, 26352 Neighboring gene methyltransferase like 21C Neighboring gene predicted gene 8251

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables aminopeptidase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables peptidase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables peptide binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables serine-type endopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables serine-type peptidase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables tripeptidyl-peptidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables tripeptidyl-peptidase activity ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    involved_in proteolysis ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nuclear body ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    tripeptidyl-peptidase 2
    Names
    TPP-II
    tripeptidyl aminopeptidase
    NP_001297469.1
    NP_033444.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001310540.1NP_001297469.1  tripeptidyl-peptidase 2 isoform 2

      See identical proteins and their annotated locations for NP_001297469.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an alternate in-frame exon compared to variant 1. The resulting isoform (2) has the same N- and C-termini but is shorter compared to isoform 1.
      Source sequence(s)
      BC060627, BY147762
      Consensus CDS
      CCDS78577.1
      UniProtKB/Swiss-Prot
      Q64514
      Related
      ENSMUSP00000139918.2, ENSMUST00000188313.7
      Conserved Domains (3) summary
      cd04857
      Location:14489
      Peptidases_S8_Tripeptidyl_Aminopeptidase_II; Peptidase S8 family domain in Tripeptidyl aminopeptidases_II
      pfam00082
      Location:236500
      Peptidase_S8; Subtilase family
      pfam12580
      Location:777960
      TPPII; Tripeptidyl peptidase II
    2. NM_009418.3NP_033444.1  tripeptidyl-peptidase 2 isoform 1

      See identical proteins and their annotated locations for NP_033444.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      BB725588, BC060627, BY147762
      Consensus CDS
      CCDS14926.1
      UniProtKB/Swiss-Prot
      Q64514
      Related
      ENSMUSP00000085244.4, ENSMUST00000087933.10
      Conserved Domains (3) summary
      cd04857
      Location:14489
      Peptidases_S8_Tripeptidyl_Aminopeptidase_II; Peptidase S8 family domain in Tripeptidyl aminopeptidases_II
      pfam00082
      Location:236500
      Peptidase_S8; Subtilase family
      pfam12580
      Location:777960
      TPPII; Tripeptidyl peptidase II

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000067.7 Reference GRCm39 C57BL/6J

      Range
      43973130..44042160
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    RNA

    1. XR_373249.4 RNA Sequence

    2. XR_001784011.2 RNA Sequence

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