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    Ppp1r13b protein phosphatase 1, regulatory subunit 13B [ Mus musculus (house mouse) ]

    Gene ID: 21981, updated on 2-Oct-2021

    Summary

    Official Symbol
    Ppp1r13bprovided by MGI
    Official Full Name
    protein phosphatase 1, regulatory subunit 13Bprovided by MGI
    Primary source
    MGI:MGI:1336199
    See related
    Ensembl:ENSMUSG00000021285
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    p85; ASPP1; Tp53bp2; AI449786; AW545810; Trp53bp2
    Expression
    Ubiquitous expression in lung adult (RPKM 13.8), genital fat pad adult (RPKM 10.7) and 28 other tissues See more
    Orthologs
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    Genomic context

    See Ppp1r13b in Genome Data Viewer
    Location:
    12; 12 F1
    Exon count:
    19
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 12 NC_000078.7 (111794892..111874549, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 12 NC_000078.6 (111828457..111908119, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 12 NC_000078.5 (113066669..113146266, complement)

    Chromosome 12 - NC_000078.7Genomic Context describing neighboring genes Neighboring gene kinesin light chain 1 Neighboring gene X-ray repair complementing defective repair in Chinese hamster cells 3 Neighboring gene zinc finger, FYVE domain containing 21 Neighboring gene predicted gene, 53769 Neighboring gene NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, assembly factor 4 pseudogene Neighboring gene small nucleolar RNA SNORA48 Neighboring gene predicted gene, 40898 Neighboring gene high mobility group box 1 pseudogene

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables p53 binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables transcription factor binding IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    acts_upstream_of_or_within apoptotic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in apoptotic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in intrinsic apoptotic signaling pathway by p53 class mediator ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of cell cycle IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    apoptosis-stimulating of p53 protein 1
    Names
    protein phosphatase 1, regulatory (inhibitor) subunit 13B
    transformation related protein 53 binding protein 2
    tumor protein p53 binding protein, 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_011625.1NP_035755.1  apoptosis-stimulating of p53 protein 1

      See identical proteins and their annotated locations for NP_035755.1

      Status: PROVISIONAL

      Source sequence(s)
      BC054788
      Consensus CDS
      CCDS56866.1
      UniProtKB/Swiss-Prot
      Q62415
      Related
      ENSMUSP00000062464.8, ENSMUST00000054815.15
      Conserved Domains (7) summary
      cd00204
      Location:8831006
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      pfam07321
      Location:154317
      YscO; Type III secretion protein YscO
      pfam12796
      Location:889975
      Ank_2; Ankyrin repeats (3 copies)
      pfam13863
      Location:153247
      DUF4200; Domain of unknown function (DUF4200)
      sd00045
      Location:889915
      ANK; ANK repeat [structural motif]
      cl09111
      Location:208318
      Prefoldin; Prefoldin is a hexameric molecular chaperone complex, found in both eukaryotes and archaea, that binds and stabilizes newly synthesized polypeptides allowing them to fold correctly. The complex contains two alpha and four beta subunits, the two subunits ...
      cl17036
      Location:10191075
      SH3; Src Homology 3 domain superfamily

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000078.7 Reference GRCm39 C57BL/6J

      Range
      111794892..111874549 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006515796.5XP_006515859.1  apoptosis-stimulating of p53 protein 1 isoform X1

      Conserved Domains (6) summary
      PHA03247
      Location:479895
      PHA03247; large tegument protein UL36; Provisional
      TIGR02168
      Location:153329
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      sd00045
      Location:924950
      ANK; ANK repeat [structural motif]
      cd17224
      Location:286
      RA_ASPP1; Ras-associating (RA) domain found in apoptosis-stimulating protein of p53 protein 1 (ASPP1)
      pfam12796
      Location:9241010
      Ank_2; Ankyrin repeats (3 copies)
      cl17036
      Location:10541110
      SH3; Src Homology 3 domain superfamily
    2. XM_006515797.5XP_006515860.1  apoptosis-stimulating of p53 protein 1 isoform X2

      Related
      ENSMUSP00000152424.2, ENSMUST00000220486.2
      Conserved Domains (6) summary
      PHA03247
      Location:476892
      PHA03247; large tegument protein UL36; Provisional
      TIGR02168
      Location:150326
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      sd00045
      Location:921947
      ANK; ANK repeat [structural motif]
      cd17224
      Location:183
      RA_ASPP1; Ras-associating (RA) domain found in apoptosis-stimulating protein of p53 protein 1 (ASPP1)
      pfam12796
      Location:9211007
      Ank_2; Ankyrin repeats (3 copies)
      cl17036
      Location:10511107
      SH3; Src Homology 3 domain superfamily
    3. XM_030246683.2XP_030102543.1  apoptosis-stimulating of p53 protein 1 isoform X3

      Conserved Domains (6) summary
      PHA03247
      Location:441857
      PHA03247; large tegument protein UL36; Provisional
      TIGR02168
      Location:150326
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      sd00045
      Location:886912
      ANK; ANK repeat [structural motif]
      cd17224
      Location:183
      RA_ASPP1; Ras-associating (RA) domain found in apoptosis-stimulating protein of p53 protein 1 (ASPP1)
      pfam12796
      Location:886972
      Ank_2; Ankyrin repeats (3 copies)
      cl17036
      Location:10161072
      SH3; Src Homology 3 domain superfamily
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