Format

Send to:

Choose Destination
    • Showing Current items.

    Top2a topoisomerase (DNA) II alpha [ Mus musculus (house mouse) ]

    Gene ID: 21973, updated on 5-Sep-2021

    Summary

    Official Symbol
    Top2aprovided by MGI
    Official Full Name
    topoisomerase (DNA) II alphaprovided by MGI
    Primary source
    MGI:MGI:98790
    See related
    Ensembl:ENSMUSG00000020914
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Top; Top-2
    Expression
    Biased expression in CNS E11.5 (RPKM 79.9), liver E14 (RPKM 47.8) and 10 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See Top2a in Genome Data Viewer
    Location:
    11 D; 11 62.91 cM
    Exon count:
    36
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (98883773..98915037, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (98992947..99024199, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 11 NC_000077.5 (98854261..98885503, complement)

    Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene retinoic acid receptor, alpha Neighboring gene predicted gene, 22061 Neighboring gene gap junction protein, delta 3 Neighboring gene predicted gene, 23451 Neighboring gene insulin-like growth factor binding protein 4 Neighboring gene tensin 4

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (1)  1 citation
    • Endonuclease-mediated (2) 

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ATP binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables ATP-dependent activity, acting on DNA ISO
    Inferred from Sequence Orthology
    more info
     
    enables DNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables DNA binding, bending ISO
    Inferred from Sequence Orthology
    more info
     
    enables DNA topoisomerase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    enables DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables chromatin binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables enzyme binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables histone deacetylase binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables isomerase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables magnesium ion binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein C-terminus binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein heterodimerization activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein homodimerization activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein kinase C binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables sequence-specific DNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables ubiquitin binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    involved_in DNA ligation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in DNA metabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within DNA topological change IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in DNA topological change ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in apoptotic chromosome condensation IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in apoptotic chromosome condensation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cellular response to DNA damage stimulus ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within chromosome condensation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within chromosome segregation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within chromosome segregation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in chromosome segregation ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within embryonic cleavage IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in female meiosis chromosome separation TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in female meiotic nuclear division IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within hematopoietic progenitor cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of DNA duplex unwinding ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of single stranded viral RNA replication via double stranded DNA intermediate ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in regulation of circadian rhythm IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in resolution of meiotic recombination intermediates IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    acts_upstream_of_or_within rhythmic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in sister chromatid segregation IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    Component Evidence Code Pubs
    part_of DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) complex ISO
    Inferred from Sequence Orthology
    more info
     
    colocalizes_with centriole ISO
    Inferred from Sequence Orthology
    more info
     
    located_in chromosome, centromeric region IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in condensed chromosome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in condensed chromosome IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    colocalizes_with nuclear chromosome ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleolus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in nucleolus ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleoplasm TAS
    Traceable Author Statement
    more info
     
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    is_active_in nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    part_of protein-containing complex ISO
    Inferred from Sequence Orthology
    more info
     
    part_of ribonucleoprotein complex ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    DNA topoisomerase 2-alpha
    Names
    DNA Topoisomerase II alpha
    DNA topoisomerase II, alpha isozyme
    NP_035753.2
    XP_006533216.1
    XP_006533217.1
    XP_006533218.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_011623.2NP_035753.2  DNA topoisomerase 2-alpha

      See identical proteins and their annotated locations for NP_035753.2

      Status: VALIDATED

      Source sequence(s)
      AL591067
      Consensus CDS
      CCDS25370.1
      UniProtKB/Swiss-Prot
      Q01320
      Related
      ENSMUSP00000068896.8, ENSMUST00000068031.8
      Conserved Domains (2) summary
      PTZ00108
      Location:241441
      PTZ00108; DNA topoisomerase 2-like protein; Provisional
      pfam08070
      Location:14311517
      DTHCT; DTHCT (NUC029) region

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000077.7 Reference GRCm39 C57BL/6J

      Range
      98883773..98915037 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006533155.4XP_006533218.1  DNA topoisomerase 2-alpha isoform X2

      See identical proteins and their annotated locations for XP_006533218.1

      Conserved Domains (2) summary
      PTZ00108
      Location:241440
      PTZ00108; DNA topoisomerase 2-like protein; Provisional
      pfam08070
      Location:14301516
      DTHCT; DTHCT (NUC029) region
    2. XM_006533153.4XP_006533216.1  DNA topoisomerase 2-alpha isoform X1

      See identical proteins and their annotated locations for XP_006533216.1

      UniProtKB/Swiss-Prot
      Q01320
      Conserved Domains (2) summary
      PTZ00108
      Location:241441
      PTZ00108; DNA topoisomerase 2-like protein; Provisional
      pfam08070
      Location:14311517
      DTHCT; DTHCT (NUC029) region
    3. XM_006533154.4XP_006533217.1  DNA topoisomerase 2-alpha isoform X2

      See identical proteins and their annotated locations for XP_006533217.1

      Conserved Domains (2) summary
      PTZ00108
      Location:241440
      PTZ00108; DNA topoisomerase 2-like protein; Provisional
      pfam08070
      Location:14301516
      DTHCT; DTHCT (NUC029) region
    Support Center