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    Top2a topoisomerase (DNA) II alpha [ Mus musculus (house mouse) ]

    Gene ID: 21973, updated on 2-Oct-2018

    Summary

    Official Symbol
    Top2aprovided by MGI
    Official Full Name
    topoisomerase (DNA) II alphaprovided by MGI
    Primary source
    MGI:MGI:98790
    See related
    Ensembl:ENSMUSG00000020914 Vega:OTTMUSG00000006446
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Top-2
    Expression
    Biased expression in CNS E11.5 (RPKM 79.9), liver E14 (RPKM 47.8) and 10 other tissues See more
    Orthologs

    Genomic context

    See Top2a in Genome Data Viewer
    Location:
    11 D; 11 62.91 cM
    Exon count:
    36
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 11 NC_000077.6 (98992947..99024205, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 11 NC_000077.5 (98854261..98885503, complement)

    Chromosome 11 - NC_000077.6Genomic Context describing neighboring genes Neighboring gene retinoic acid receptor, alpha Neighboring gene predicted gene, 46294 Neighboring gene gap junction protein, delta 3 Neighboring gene insulin-like growth factor binding protein 4 Neighboring gene tensin 4

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 

    Pathways from BioSystems

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    ATP binding ISO
    Inferred from Sequence Orthology
    more info
     
    DNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    DNA binding, bending ISO
    Inferred from Sequence Orthology
    more info
     
    DNA topoisomerase activity ISO
    Inferred from Sequence Orthology
    more info
     
    DNA topoisomerase type II (ATP-hydrolyzing) activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    DNA topoisomerase type II (ATP-hydrolyzing) activity IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    DNA topoisomerase type II (ATP-hydrolyzing) activity ISO
    Inferred from Sequence Orthology
    more info
     
    DNA-dependent ATPase activity ISO
    Inferred from Sequence Orthology
    more info
     
    chromatin binding ISO
    Inferred from Sequence Orthology
    more info
     
    drug binding ISO
    Inferred from Sequence Orthology
    more info
     
    enzyme binding ISO
    Inferred from Sequence Orthology
    more info
     
    histone deacetylase binding ISO
    Inferred from Sequence Orthology
    more info
     
    isomerase activity IEA
    Inferred from Electronic Annotation
    more info
     
    magnesium ion binding ISO
    Inferred from Sequence Orthology
    more info
     
    metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
     
    protein C-terminus binding ISO
    Inferred from Sequence Orthology
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein heterodimerization activity ISO
    Inferred from Sequence Orthology
    more info
     
    protein homodimerization activity ISO
    Inferred from Sequence Orthology
    more info
     
    protein kinase C binding ISO
    Inferred from Sequence Orthology
    more info
     
    sequence-specific DNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    ubiquitin binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    DNA ligation ISO
    Inferred from Sequence Orthology
    more info
     
    DNA metabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    DNA topological change IDA
    Inferred from Direct Assay
    more info
    PubMed 
    DNA topological change ISO
    Inferred from Sequence Orthology
    more info
     
    apoptotic chromosome condensation IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    apoptotic chromosome condensation ISO
    Inferred from Sequence Orthology
    more info
     
    cellular response to DNA damage stimulus ISO
    Inferred from Sequence Orthology
    more info
     
    chromosome condensation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    chromosome segregation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    chromosome segregation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    chromosome segregation ISO
    Inferred from Sequence Orthology
    more info
     
    embryonic cleavage IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    female meiosis chromosome separation TAS
    Traceable Author Statement
    more info
    PubMed 
    female meiotic nuclear division IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    hematopoietic progenitor cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    mitotic DNA integrity checkpoint IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    negative regulation of DNA duplex unwinding ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of single stranded viral RNA replication via double stranded DNA intermediate ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of transcription by RNA polymerase II IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of circadian rhythm IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    resolution of meiotic recombination intermediates IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    rhythmic process IEA
    Inferred from Electronic Annotation
    more info
     
    sister chromatid segregation IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    Component Evidence Code Pubs
    DNA topoisomerase complex (ATP-hydrolyzing) ISO
    Inferred from Sequence Orthology
    more info
     
    colocalizes_with centriole ISO
    Inferred from Sequence Orthology
    more info
     
    condensed chromosome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    condensed chromosome IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    colocalizes_with nuclear chromosome ISO
    Inferred from Sequence Orthology
    more info
     
    nucleolus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nucleolus ISO
    Inferred from Sequence Orthology
    more info
     
    nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    protein-containing complex ISO
    Inferred from Sequence Orthology
    more info
     
    ribonucleoprotein complex ISO
    Inferred from Sequence Orthology
    more info
     
    viral integration complex ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    DNA topoisomerase 2-alpha
    Names
    DNA Topoisomerase II alpha
    DNA topoisomerase II, alpha isozyme
    NP_035753.2
    XP_006533216.1
    XP_006533217.1
    XP_006533218.1

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_011623.2NP_035753.2  DNA topoisomerase 2-alpha

      See identical proteins and their annotated locations for NP_035753.2

      Status: VALIDATED

      Source sequence(s)
      AL591067
      Consensus CDS
      CCDS25370.1
      UniProtKB/Swiss-Prot
      Q01320
      Related
      ENSMUSP00000068896.7, OTTMUSP00000006845, ENSMUST00000068031.7, OTTMUST00000014727
      Conserved Domains (7) summary
      cd03365
      Location:454574
      TOPRIM_TopoIIA; TOPRIM_TopoIIA: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to Saccharomyces cerevisiae Topoisomerase II. TopoIIA enzymes cut both strands of ...
      cd00187
      Location:7101171
      TOP4c; DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes in DNA ...
      cd03481
      Location:264416
      TopoIIA_Trans_ScTopoIIA; TopoIIA_Trans_ScTopoIIA: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to Saccharomyces cerevisiae Topo IIA. S. cerevisiae Topo IIA is a homodimer encoded ...
      PTZ00108
      Location:241441
      PTZ00108; DNA topoisomerase 2-like protein; Provisional
      pfam02518
      Location:79184
      HATPase_c; Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase
      pfam08070
      Location:14311517
      DTHCT; DTHCT (NUC029) region
      pfam16898
      Location:572710
      TOPRIM_C; C-terminal associated domain of TOPRIM

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000077.6 Reference GRCm38.p4 C57BL/6J

      Range
      98992947..99024205 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006533155.2XP_006533218.1  DNA topoisomerase 2-alpha isoform X2

      See identical proteins and their annotated locations for XP_006533218.1

      Conserved Domains (7) summary
      cd03365
      Location:454574
      TOPRIM_TopoIIA; TOPRIM_TopoIIA: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to Saccharomyces cerevisiae Topoisomerase II. TopoIIA enzymes cut both strands of ...
      cd00187
      Location:7101171
      TOP4c; DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes in DNA ...
      cd03481
      Location:264416
      TopoIIA_Trans_ScTopoIIA; TopoIIA_Trans_ScTopoIIA: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to Saccharomyces cerevisiae Topo IIA. S. cerevisiae Topo IIA is a homodimer encoded ...
      PTZ00108
      Location:241440
      PTZ00108; DNA topoisomerase 2-like protein; Provisional
      pfam02518
      Location:79184
      HATPase_c; Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase
      pfam08070
      Location:14301516
      DTHCT; DTHCT (NUC029) region
      pfam16898
      Location:572710
      TOPRIM_C; C-terminal associated domain of TOPRIM
    2. XM_006533154.2XP_006533217.1  DNA topoisomerase 2-alpha isoform X2

      See identical proteins and their annotated locations for XP_006533217.1

      Conserved Domains (7) summary
      cd03365
      Location:454574
      TOPRIM_TopoIIA; TOPRIM_TopoIIA: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to Saccharomyces cerevisiae Topoisomerase II. TopoIIA enzymes cut both strands of ...
      cd00187
      Location:7101171
      TOP4c; DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes in DNA ...
      cd03481
      Location:264416
      TopoIIA_Trans_ScTopoIIA; TopoIIA_Trans_ScTopoIIA: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to Saccharomyces cerevisiae Topo IIA. S. cerevisiae Topo IIA is a homodimer encoded ...
      PTZ00108
      Location:241440
      PTZ00108; DNA topoisomerase 2-like protein; Provisional
      pfam02518
      Location:79184
      HATPase_c; Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase
      pfam08070
      Location:14301516
      DTHCT; DTHCT (NUC029) region
      pfam16898
      Location:572710
      TOPRIM_C; C-terminal associated domain of TOPRIM
    3. XM_006533153.2XP_006533216.1  DNA topoisomerase 2-alpha isoform X1

      See identical proteins and their annotated locations for XP_006533216.1

      UniProtKB/Swiss-Prot
      Q01320
      Conserved Domains (7) summary
      cd03365
      Location:454574
      TOPRIM_TopoIIA; TOPRIM_TopoIIA: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to Saccharomyces cerevisiae Topoisomerase II. TopoIIA enzymes cut both strands of ...
      cd00187
      Location:7101171
      TOP4c; DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes in DNA ...
      cd03481
      Location:264416
      TopoIIA_Trans_ScTopoIIA; TopoIIA_Trans_ScTopoIIA: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to Saccharomyces cerevisiae Topo IIA. S. cerevisiae Topo IIA is a homodimer encoded ...
      PTZ00108
      Location:241441
      PTZ00108; DNA topoisomerase 2-like protein; Provisional
      pfam02518
      Location:79184
      HATPase_c; Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase
      pfam08070
      Location:14311517
      DTHCT; DTHCT (NUC029) region
      pfam16898
      Location:572710
      TOPRIM_C; C-terminal associated domain of TOPRIM
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