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    FAU FAU ubiquitin like and ribosomal protein S30 fusion [ Homo sapiens (human) ]

    Gene ID: 2197, updated on 5-May-2024

    Summary

    Official Symbol
    FAUprovided by HGNC
    Official Full Name
    FAU ubiquitin like and ribosomal protein S30 fusionprovided by HGNC
    Primary source
    HGNC:HGNC:3597
    See related
    Ensembl:ENSG00000149806 MIM:134690; AllianceGenome:HGNC:3597
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    S30; FAU1; Fub1; Fubi; asr1; eS30; RPS30; MNSFbeta
    Summary
    This gene is the cellular homolog of the fox sequence in the Finkel-Biskis-Reilly murine sarcoma virus (FBR-MuSV). It encodes a fusion protein consisting of the ubiquitin-like protein fubi at the N terminus and ribosomal protein S30 at the C terminus. It has been proposed that the fusion protein is post-translationally processed to generate free fubi and free ribosomal protein S30. Fubi is a member of the ubiquitin family, and ribosomal protein S30 belongs to the S30E family of ribosomal proteins. Whereas the function of fubi is currently unknown, ribosomal protein S30 is a component of the 40S subunit of the cytoplasmic ribosome and displays antimicrobial activity. Pseudogenes derived from this gene are present in the genome. Similar to ribosomal protein S30, ribosomal proteins S27a and L40 are synthesized as fusion proteins with ubiquitin. [provided by RefSeq, Nov 2014]
    Expression
    Ubiquitous expression in ovary (RPKM 446.2), bone marrow (RPKM 364.4) and 25 other tissues See more
    Orthologs
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    Genomic context

    See FAU in Genome Data Viewer
    Location:
    11q13.1
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 11 NC_000011.10 (65120630..65122134, complement)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 11 NC_060935.1 (65113909..65115413, complement)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (64888102..64889606, complement)

    Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:64878527-64879452 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4942 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3509 Neighboring gene transmembrane 7 superfamily member 2 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:64882956-64883501 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:64883502-64884046 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:64884593-64885136 Neighboring gene Sharpr-MPRA regulatory region 3974 Neighboring gene zinc finger HIT-type containing 2 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4943 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4944 Neighboring gene mitochondrial ribosomal protein L49 Neighboring gene synoviolin 1 Neighboring gene microRNA 6751

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    HIV-1 interactions

    Protein interactions

    Protein Gene Interaction Pubs
    Rev rev HIV-1 Rev interacting protein, Finkel-Biskis-Reilly murine sarcoma virus ubiquitously expressed (FAU), is identified by the in-vitro binding experiments involving cytosolic or nuclear extracts from HeLa cells PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • FLJ22986

    Gene Ontology Provided by GOA

    General protein information

    Preferred Names
    ubiquitin-like FUBI-ribosomal protein eS30 fusion protein
    Names
    40S ribosomal protein S30
    FAU ubiquitin-like and ribosomal protein S30
    FAU-encoded ubiquitin-like protein
    FBR-MuSV-associated ubiquitously expressed
    Finkel-Biskis-Reilly murine sarcoma virus (FBR-MuSV) ubiquitously expressed (fox derived)
    monoclonal nonspecific suppressor factor beta
    ribosomal protein S30
    small ribosomal subunit protein eS30
    ubiquitin-like protein fubi and ribosomal protein S30
    ubiquitin-like-S30 fusion protein

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001997.5NP_001988.1  ubiquitin-like FUBI-ribosomal protein eS30 fusion protein precursor

      See identical proteins and their annotated locations for NP_001988.1

      Status: REVIEWED

      Source sequence(s)
      AA449261, BC033877, BU602831
      Consensus CDS
      CCDS8095.1
      UniProtKB/Swiss-Prot
      P35544, P62861, Q05472, Q95261, Q9H5V4
      UniProtKB/TrEMBL
      E9PM49
      Related
      ENSP00000435370.1, ENST00000529639.6
      Conserved Domains (2) summary
      cd01793
      Location:174
      Ubl_FUBI; ubiquitin-like (Ubl) domain found in ubiquitin-like protein FUBI and similar proteins
      pfam04758
      Location:75132
      Ribosomal_S30; Ribosomal protein S30

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000011.10 Reference GRCh38.p14 Primary Assembly

      Range
      65120630..65122134 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060935.1 Alternate T2T-CHM13v2.0

      Range
      65113909..65115413 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)