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    OR5AR1 olfactory receptor family 5 subfamily AR member 1 [ Homo sapiens (human) ]

    Gene ID: 219493, updated on 5-Mar-2024

    Summary

    Official Symbol
    OR5AR1provided by HGNC
    Official Full Name
    olfactory receptor family 5 subfamily AR member 1provided by HGNC
    Primary source
    HGNC:HGNC:15260
    See related
    Ensembl:ENSG00000172459 AllianceGenome:HGNC:15260
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    OR11-209
    Summary
    Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. This olfactory receptor gene is a segregating pseudogene, where some individuals have an allele that encodes a functional olfactory receptor, while other individuals have an allele encoding a protein that is predicted to be non-functional. [provided by RefSeq, Jun 2015]
    Annotation information
    Note: Genetic polymorphisms result in both protein coding and non-coding alleles of this gene.
    Orthologs
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    Genomic context

    See OR5AR1 in Genome Data Viewer
    Location:
    11q12.1
    Exon count:
    1
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 11 NC_000011.10 (56663686..56664618)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 11 NC_060935.1 (56601694..56602626)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (56431162..56432094)

    Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene olfactory receptor family 5 subfamily AP member 1 pseudogene Neighboring gene olfactory receptor family 5 subfamily AP member 2 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr11:56426970-56427578 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr11:56427579-56428187 Neighboring gene olfactory receptor family 2 subfamily AH member 1 pseudogene Neighboring gene TMEM230 pseudogene 2

    Genomic regions, transcripts, and products

    Phenotypes

    EBI GWAS Catalog

    Description
    Genome-wide association and linkage analyses of hemostatic factors and hematological phenotypes in the Framingham Heart Study.
    EBI GWAS Catalog

    General gene information

    Markers

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables G protein-coupled receptor activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables copper ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables odorant binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables olfactory receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Component Evidence Code Pubs
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    olfactory receptor 5AR1
    Names
    olfactory receptor OR11-209

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001004730.1NP_001004730.1  olfactory receptor 5AR1

      See identical proteins and their annotated locations for NP_001004730.1

      Status: VALIDATED

      Source sequence(s)
      AB065740
      UniProtKB/Swiss-Prot
      Q6IF61, Q8NGP9
      UniProtKB/TrEMBL
      A0A126GVM6, B9EIN0
      Related
      ENSP00000485240.1, ENST00000624596.2
      Conserved Domains (2) summary
      pfam00001
      Location:41290
      7tm_1; 7 transmembrane receptor (rhodopsin family)
      cl21561
      Location:31308
      7tm_4; Olfactory receptor

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000011.10 Reference GRCh38.p14 Primary Assembly

      Range
      56663686..56664618
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060935.1 Alternate T2T-CHM13v2.0

      Range
      56601694..56602626
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)