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    Dedd death effector domain-containing [ Mus musculus (house mouse) ]

    Gene ID: 21945, updated on 2-Oct-2018

    Summary

    Official Symbol
    Deddprovided by MGI
    Official Full Name
    death effector domain-containingprovided by MGI
    Primary source
    MGI:MGI:1333874
    See related
    Ensembl:ENSMUSG00000013973 Vega:OTTMUSG00000021703
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    DEFT; KE05; FLDED1; Dedpro1; CASP8IP1
    Expression
    Ubiquitous expression in testis adult (RPKM 26.5), large intestine adult (RPKM 9.3) and 28 other tissues See more
    Orthologs

    Genomic context

    See Dedd in Genome Data Viewer
    Location:
    1 H3; 1 79.34 cM
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 1 NC_000067.6 (171327165..171342501)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 1 NC_000067.5 (173259276..173272632)

    Chromosome 1 - NC_000067.6Genomic Context describing neighboring genes Neighboring gene ubiquitin-fold modifier conjugating enzyme 1 Neighboring gene ribosomal protein L27, pseudogene 1 Neighboring gene uncharacterized LOC105244007 Neighboring gene nitrilase 1 Neighboring gene prefoldin 2 Neighboring gene kelch domain containing 9

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    DNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Component Evidence Code Pubs
    cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nucleolus IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    nucleolus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nucleus IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    death effector domain-containing protein
    Names
    tumor necrosis factor (ligand) superfamily, member 19

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001128609.1NP_001122081.1  death effector domain-containing protein

      See identical proteins and their annotated locations for NP_001122081.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) is the longer transcript. Both variants 1 and 2 encode the same protein.
      Source sequence(s)
      AC084821, AK009728, BM947911
      Consensus CDS
      CCDS15490.1
      UniProtKB/Swiss-Prot
      Q9Z1L3
      UniProtKB/TrEMBL
      Q3U001
      Related
      ENSMUSP00000106931.1, OTTMUSP00000024250, ENSMUST00000111300.7, OTTMUST00000051499
      Conserved Domains (1) summary
      cd08790
      Location:22118
      DED_DEDD; Death Effector Domain of DEDD
    2. NM_001357550.1NP_001344479.1  death effector domain-containing protein

      Status: VALIDATED

      Source sequence(s)
      AC084821
      Conserved Domains (1) summary
      cd08790
      Location:22118
      DED_DEDD; Death Effector Domain of DEDD
    3. NM_001357551.1NP_001344480.1  death effector domain-containing protein

      Status: VALIDATED

      Source sequence(s)
      AC084821
      Conserved Domains (1) summary
      cd08790
      Location:22118
      DED_DEDD; Death Effector Domain of DEDD
    4. NM_001357552.1NP_001344481.1  death effector domain-containing protein

      Status: VALIDATED

      Source sequence(s)
      AC084821
      Conserved Domains (1) summary
      cd08790
      Location:22118
      DED_DEDD; Death Effector Domain of DEDD
    5. NM_001357553.1NP_001344482.1  death effector domain-containing protein

      Status: VALIDATED

      Source sequence(s)
      AC084821
      Conserved Domains (1) summary
      cd08790
      Location:22118
      DED_DEDD; Death Effector Domain of DEDD
    6. NM_011615.3NP_035745.3  death effector domain-containing protein

      See identical proteins and their annotated locations for NP_035745.3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an internal 5' UTR exon, as compared to variant 1.
      Source sequence(s)
      AC084821, AK009728, BM947911
      Consensus CDS
      CCDS15490.1
      UniProtKB/Swiss-Prot
      Q9Z1L3
      UniProtKB/TrEMBL
      Q3U001
      Related
      ENSMUSP00000068419.4, OTTMUSP00000024257, ENSMUST00000064950.10, OTTMUST00000051512
      Conserved Domains (1) summary
      cd08790
      Location:22118
      DED_DEDD; Death Effector Domain of DEDD

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000067.6 Reference GRCm38.p4 C57BL/6J

      Range
      171327165..171342501
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006496739.3XP_006496802.1  death effector domain-containing protein isoform X1

      See identical proteins and their annotated locations for XP_006496802.1

      UniProtKB/Swiss-Prot
      Q9Z1L3
      UniProtKB/TrEMBL
      Q3U001
      Related
      ENSMUSP00000106930.1, OTTMUSP00000024258, ENSMUST00000111299.7, OTTMUST00000051513
      Conserved Domains (1) summary
      cd08790
      Location:22118
      DED_DEDD; Death Effector Domain of DEDD
    2. XM_006496738.3XP_006496801.1  death effector domain-containing protein isoform X1

      UniProtKB/Swiss-Prot
      Q9Z1L3
      UniProtKB/TrEMBL
      Q3U001
      Conserved Domains (1) summary
      cd08790
      Location:22118
      DED_DEDD; Death Effector Domain of DEDD
    3. XM_006496740.3XP_006496803.1  death effector domain-containing protein isoform X1

      UniProtKB/Swiss-Prot
      Q9Z1L3
      UniProtKB/TrEMBL
      Q3U001
      Conserved Domains (1) summary
      cd08790
      Location:22118
      DED_DEDD; Death Effector Domain of DEDD
    4. XM_011238782.2XP_011237084.1  death effector domain-containing protein isoform X1

      See identical proteins and their annotated locations for XP_011237084.1

      UniProtKB/Swiss-Prot
      Q9Z1L3
      UniProtKB/TrEMBL
      Q3U001
      Conserved Domains (1) summary
      cd08790
      Location:22118
      DED_DEDD; Death Effector Domain of DEDD
    5. XM_006496741.3XP_006496804.1  death effector domain-containing protein isoform X1

      See identical proteins and their annotated locations for XP_006496804.1

      UniProtKB/Swiss-Prot
      Q9Z1L3
      UniProtKB/TrEMBL
      Q3U001
      Related
      ENSMUSP00000095075.1, OTTMUSP00000024259, ENSMUST00000097467.7, OTTMUST00000051514
      Conserved Domains (1) summary
      cd08790
      Location:22118
      DED_DEDD; Death Effector Domain of DEDD
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