Format

Send to:

Choose Destination
    • Showing Current items.

    Tmpo thymopoietin [ Mus musculus (house mouse) ]

    Gene ID: 21917, updated on 1-Nov-2018

    Summary

    Official Symbol
    Tmpoprovided by MGI
    Official Full Name
    thymopoietinprovided by MGI
    Primary source
    MGI:MGI:106920
    See related
    Ensembl:ENSMUSG00000019961 Vega:OTTMUSG00000063806
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    TP; LAP2; AI195756; AI606875; AW214352; AW547477; 5630400D24Rik
    Expression
    Broad expression in CNS E11.5 (RPKM 41.2), limb E14.5 (RPKM 32.4) and 27 other tissues See more
    Orthologs

    Genomic context

    See Tmpo in Genome Data Viewer
    Location:
    10 C2; 10 45.66 cM
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 10 NC_000076.6 (91147571..91181716, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 10 NC_000076.5 (90610316..90634327, complement)

    Chromosome 10 - NC_000076.6Genomic Context describing neighboring genes Neighboring gene apoptotic peptidase activating factor 1 Neighboring gene IKBKB interacting protein Neighboring gene solute carrier family 25 (mitochondrial carrier, phosphate carrier), member 3 Neighboring gene nuclear encoded tRNA aspartic acid 16 (anticodon GTC) Neighboring gene nuclear encoded tRNA trytophan 2 (anticodon CCA) Neighboring gene RIKEN cDNA 4930534H03 gene

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    DNA binding IEA
    Inferred from Electronic Annotation
    more info
     
    identical protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    regulation of transcription, DNA-templated IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Component Evidence Code Pubs
    chromatin ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    chromosome IEA
    Inferred from Electronic Annotation
    more info
     
    colocalizes_with endoplasmic reticulum membrane ISO
    Inferred from Sequence Orthology
    more info
     
    integral component of membrane IEA
    Inferred from Electronic Annotation
    more info
     
    membrane IEA
    Inferred from Electronic Annotation
    more info
     
    nuclear envelope IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nuclear envelope ISO
    Inferred from Sequence Orthology
    more info
     
    nuclear inner membrane ISO
    Inferred from Sequence Orthology
    more info
     
    nuclear membrane ISO
    Inferred from Sequence Orthology
    more info
     
    nucleus ISO
    Inferred from Sequence Orthology
    more info
    PubMed 

    General protein information

    Preferred Names
    lamina-associated polypeptide 2

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001080129.2NP_001073598.1  lamina-associated polypeptide 2 isoform epsilon

      See identical proteins and their annotated locations for NP_001073598.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) contains most exons of this gene and encodes isoform (epsilon).
      Source sequence(s)
      AA177175, AC140410, AK165851, CJ071529
      Consensus CDS
      CCDS36035.1
      UniProtKB/Swiss-Prot
      Q61029
      Related
      ENSMUSP00000072092.7, OTTMUSP00000080767, ENSMUST00000072239.13, OTTMUST00000155461
      Conserved Domains (2) summary
      cd12940
      Location:110138
      LEM_LAP2_LEMD1; LEM (Lap2/Emerin/Man1) domain found in lamina-associated polypeptide 2 (LAP2), LEM domain-containing protein 1 (LEMP-1) and similar proteins
      pfam08198
      Location:249
      Thymopoietin; Thymopoietin protein
    2. NM_001080130.2NP_001073599.1  lamina-associated polypeptide 2 isoform delta

      See identical proteins and their annotated locations for NP_001073599.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) lacks an in-frame exon in the coding region, compared to variant 3. The resulting isoform (delta) lacks an internal segment, compared to isoform epsilon.
      Source sequence(s)
      AA177175, AC140410, AK165282, CJ071529
      Consensus CDS
      CCDS36034.1
      UniProtKB/TrEMBL
      Q3TNH0
      Related
      ENSMUSP00000089864.6, OTTMUSP00000080770, ENSMUST00000092219.13, OTTMUST00000155465
      Conserved Domains (2) summary
      cd12940
      Location:110138
      LEM_LAP2_LEMD1; LEM (Lap2/Emerin/Man1) domain found in lamina-associated polypeptide 2 (LAP2), LEM domain-containing protein 1 (LEMP-1) and similar proteins
      pfam08198
      Location:249
      Thymopoietin; Thymopoietin protein
    3. NM_001080131.2NP_001073600.1  lamina-associated polypeptide 2 isoform gamma

      See identical proteins and their annotated locations for NP_001073600.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (5) lacks two consecutive in-frame exons in the coding region, compared to variant 3. The resulting isoform (gamma) lacks an internal segment, compared to isoform epsilon.
      Source sequence(s)
      AA177175, AC140410, AK165851, CJ071529
      Consensus CDS
      CCDS36033.1
      UniProtKB/Swiss-Prot
      Q61029
      Related
      ENSMUSP00000096956.4, OTTMUSP00000080768, ENSMUST00000099355.11, OTTMUST00000155463
      Conserved Domains (2) summary
      cd12940
      Location:110138
      LEM_LAP2_LEMD1; LEM (Lap2/Emerin/Man1) domain found in lamina-associated polypeptide 2 (LAP2), LEM domain-containing protein 1 (LEMP-1) and similar proteins
      pfam08198
      Location:249
      Thymopoietin; Thymopoietin protein
    4. NM_001080132.2NP_001073601.1  lamina-associated polypeptide 2 isoform beta

      See identical proteins and their annotated locations for NP_001073601.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks three consecutive in-frame exons in the coding region, compared to variant 3. The resulting isoform (beta) lacks an internal segment, compared to isoform epsilon.
      Source sequence(s)
      AA177175, AC140410, AK165851, CJ071529
      Consensus CDS
      CCDS36032.1
      UniProtKB/Swiss-Prot
      Q61029
      Related
      ENSMUSP00000100930.3, OTTMUSP00000080769, ENSMUST00000105293.10, OTTMUST00000155464
      Conserved Domains (2) summary
      cd12940
      Location:110138
      LEM_LAP2_LEMD1; LEM (Lap2/Emerin/Man1) domain found in lamina-associated polypeptide 2 (LAP2), LEM domain-containing protein 1 (LEMP-1) and similar proteins
      pfam08198
      Location:249
      Thymopoietin; Thymopoietin protein
    5. NM_001283048.1NP_001269977.1  lamina-associated polypeptide 2 isoform omega

      See identical proteins and their annotated locations for NP_001269977.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (7) has an alternate 5' terminal exon and initiates translation at a downstream start codon, compared to variant 3. The resulting isoform (omega) has a much shorter N-terminus, compared to isoform epsilon.
      Source sequence(s)
      AA177175, AC140410, AK159161, BY103202
      UniProtKB/TrEMBL
      Q3TXQ1
      Conserved Domains (1) summary
      cl01370
      Location:5185
      DotU; Type VI secretion system protein DotU
    6. NM_011605.3NP_035735.2  lamina-associated polypeptide 2 isoform alpha

      See identical proteins and their annotated locations for NP_035735.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) lacks several exons but has an alternate 3' terminal exon, compared to variant 3. The resulting isoform (alpha) is longer and has a distinct C-terminus, compared to isoform epsilon.
      Source sequence(s)
      AK144642, AK156206, AV450597, BC141062, CJ071529
      Consensus CDS
      CCDS24122.1
      UniProtKB/Swiss-Prot
      Q61033
      Related
      ENSMUSP00000020123.5, OTTMUSP00000080771, ENSMUST00000020123.6, OTTMUST00000155469
      Conserved Domains (3) summary
      cd12940
      Location:110138
      LEM_LAP2_LEMD1; LEM (Lap2/Emerin/Man1) domain found in lamina-associated polypeptide 2 (LAP2), LEM domain-containing protein 1 (LEMP-1) and similar proteins
      pfam08198
      Location:249
      Thymopoietin; Thymopoietin protein
      pfam11560
      Location:459692
      LAP2alpha; Lamina-associated polypeptide 2 alpha

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000076.6 Reference GRCm38.p4 C57BL/6J

      Range
      91147571..91181716 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006513590.3XP_006513653.1  lamina-associated polypeptide 2 isoform X1

      See identical proteins and their annotated locations for XP_006513653.1

      UniProtKB/TrEMBL
      Q3TXQ1
      Conserved Domains (1) summary
      cl01370
      Location:5185
      DotU; Type VI secretion system protein DotU

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001080134.1: Suppressed sequence

      Description
      NM_001080134.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.
    Support Center