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    Tmpo thymopoietin [ Mus musculus (house mouse) ]

    Gene ID: 21917, updated on 17-Aug-2021

    Summary

    Official Symbol
    Tmpoprovided by MGI
    Official Full Name
    thymopoietinprovided by MGI
    Primary source
    MGI:MGI:106920
    See related
    Ensembl:ENSMUSG00000019961
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    L; T; TP; LAP2; AI195756; AI606875; AW214352; AW547477; 5630400D24Rik
    Expression
    Broad expression in CNS E11.5 (RPKM 41.2), limb E14.5 (RPKM 32.4) and 27 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Tmpo in Genome Data Viewer
    Location:
    10 C2; 10 45.66 cM
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (90983433..91017614, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (91147571..91181752, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 10 NC_000076.5 (90610316..90634327, complement)

    Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene apoptotic peptidase activating factor 1 Neighboring gene IKBKB interacting protein Neighboring gene solute carrier family 25 (mitochondrial carrier, phosphate carrier), member 3 Neighboring gene predicted gene, 24119 Neighboring gene nuclear encoded tRNA aspartic acid 16 (anticodon GTC) Neighboring gene nuclear encoded tRNA trytophan 2 (anticodon CCA) Neighboring gene RIKEN cDNA 4930534H03 gene

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables identical protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within regulation of transcription, DNA-templated IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in chromatin ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    located_in chromosome IEA
    Inferred from Electronic Annotation
    more info
     
    located_in integral component of membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in nuclear envelope IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in nuclear envelope ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nuclear inner membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nuclear membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    PubMed 

    General protein information

    Preferred Names
    lamina-associated polypeptide 2

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001080129.2NP_001073598.1  lamina-associated polypeptide 2 isoform epsilon

      See identical proteins and their annotated locations for NP_001073598.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) contains most exons of this gene and encodes isoform (epsilon).
      Source sequence(s)
      AA177175, AC140410, AK165851, CJ071529
      Consensus CDS
      CCDS36035.1
      UniProtKB/Swiss-Prot
      Q61029
      Related
      ENSMUSP00000072092.8, ENSMUST00000072239.14
      Conserved Domains (2) summary
      cd12940
      Location:110138
      LEM_LAP2_LEMD1; LEM (Lap2/Emerin/Man1) domain found in lamina-associated polypeptide 2 (LAP2), LEM domain-containing protein 1 (LEMP-1) and similar proteins
      pfam08198
      Location:249
      Thymopoietin; Thymopoietin protein
    2. NM_001080130.2NP_001073599.1  lamina-associated polypeptide 2 isoform delta

      See identical proteins and their annotated locations for NP_001073599.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) lacks an in-frame exon in the coding region, compared to variant 3. The resulting isoform (delta) lacks an internal segment, compared to isoform epsilon.
      Source sequence(s)
      AA177175, AC140410, AK165282, CJ071529
      Consensus CDS
      CCDS36034.1
      UniProtKB/TrEMBL
      Q3TNH0
      Related
      ENSMUSP00000089864.7, ENSMUST00000092219.14
      Conserved Domains (2) summary
      cd12940
      Location:110138
      LEM_LAP2_LEMD1; LEM (Lap2/Emerin/Man1) domain found in lamina-associated polypeptide 2 (LAP2), LEM domain-containing protein 1 (LEMP-1) and similar proteins
      pfam08198
      Location:249
      Thymopoietin; Thymopoietin protein
    3. NM_001080131.2NP_001073600.1  lamina-associated polypeptide 2 isoform gamma

      See identical proteins and their annotated locations for NP_001073600.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (5) lacks two consecutive in-frame exons in the coding region, compared to variant 3. The resulting isoform (gamma) lacks an internal segment, compared to isoform epsilon.
      Source sequence(s)
      AA177175, AC140410, AK165851, CJ071529
      Consensus CDS
      CCDS36033.1
      UniProtKB/Swiss-Prot
      Q61029
      Related
      ENSMUSP00000096956.5, ENSMUST00000099355.12
      Conserved Domains (2) summary
      cd12940
      Location:110138
      LEM_LAP2_LEMD1; LEM (Lap2/Emerin/Man1) domain found in lamina-associated polypeptide 2 (LAP2), LEM domain-containing protein 1 (LEMP-1) and similar proteins
      pfam08198
      Location:249
      Thymopoietin; Thymopoietin protein
    4. NM_001080132.2NP_001073601.1  lamina-associated polypeptide 2 isoform beta

      See identical proteins and their annotated locations for NP_001073601.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks three consecutive in-frame exons in the coding region, compared to variant 3. The resulting isoform (beta) lacks an internal segment, compared to isoform epsilon.
      Source sequence(s)
      AA177175, AC140410, AK165851, CJ071529
      Consensus CDS
      CCDS36032.1
      UniProtKB/Swiss-Prot
      Q61029
      Related
      ENSMUSP00000100930.4, ENSMUST00000105293.11
      Conserved Domains (2) summary
      cd12940
      Location:110138
      LEM_LAP2_LEMD1; LEM (Lap2/Emerin/Man1) domain found in lamina-associated polypeptide 2 (LAP2), LEM domain-containing protein 1 (LEMP-1) and similar proteins
      pfam08198
      Location:249
      Thymopoietin; Thymopoietin protein
    5. NM_001283048.1NP_001269977.1  lamina-associated polypeptide 2 isoform omega

      See identical proteins and their annotated locations for NP_001269977.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (7) has an alternate 5' terminal exon and initiates translation at a downstream start codon, compared to variant 3. The resulting isoform (omega) has a much shorter N-terminus, compared to isoform epsilon.
      Source sequence(s)
      AA177175, AC140410, AK159161, BY103202
      UniProtKB/TrEMBL
      Q3TXQ1
      Conserved Domains (1) summary
      COG1426
      Location:2699
      RodZ; Cytoskeletal protein RodZ, contains Xre-like HTH and DUF4115 domains [Cell cycle control, cell division, chromosome partitioning]
    6. NM_011605.3NP_035735.2  lamina-associated polypeptide 2 isoform alpha

      See identical proteins and their annotated locations for NP_035735.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) lacks several exons but has an alternate 3' terminal exon, compared to variant 3. The resulting isoform (alpha) is longer and has a distinct C-terminus, compared to isoform epsilon.
      Source sequence(s)
      AK144642, AK156206, AV450597, BC141062, CJ071529
      Consensus CDS
      CCDS24122.1
      UniProtKB/Swiss-Prot
      Q61033
      Related
      ENSMUSP00000020123.6, ENSMUST00000020123.7
      Conserved Domains (3) summary
      cd12940
      Location:110138
      LEM_LAP2_LEMD1; LEM (Lap2/Emerin/Man1) domain found in lamina-associated polypeptide 2 (LAP2), LEM domain-containing protein 1 (LEMP-1) and similar proteins
      pfam08198
      Location:249
      Thymopoietin; Thymopoietin protein
      pfam11560
      Location:459692
      LAP2alpha; Lamina-associated polypeptide 2 alpha

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000076.7 Reference GRCm39 C57BL/6J

      Range
      90983433..91017614 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030245061.1XP_030100921.1  lamina-associated polypeptide 2 isoform X1

      Conserved Domains (1) summary
      COG1426
      Location:2699
      RodZ; Cytoskeletal protein RodZ, contains Xre-like HTH and DUF4115 domains [Cell cycle control, cell division, chromosome partitioning]
    2. XM_006513590.4XP_006513653.1  lamina-associated polypeptide 2 isoform X1

      See identical proteins and their annotated locations for XP_006513653.1

      UniProtKB/TrEMBL
      Q3TXQ1
      Conserved Domains (1) summary
      COG1426
      Location:2699
      RodZ; Cytoskeletal protein RodZ, contains Xre-like HTH and DUF4115 domains [Cell cycle control, cell division, chromosome partitioning]

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001080134.1: Suppressed sequence

      Description
      NM_001080134.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.
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