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    Hmbox1 homeobox containing 1 [ Mus musculus (house mouse) ]

    Gene ID: 219150, updated on 23-Jun-2021

    Summary

    Official Symbol
    Hmbox1provided by MGI
    Official Full Name
    homeobox containing 1provided by MGI
    Primary source
    MGI:MGI:2445066
    See related
    Ensembl:ENSMUSG00000021972
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    AI451877; AI604847; F830020C16Rik
    Expression
    Ubiquitous expression in lung adult (RPKM 16.3), thymus adult (RPKM 10.2) and 28 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See Hmbox1 in Genome Data Viewer
    Location:
    14; 14 D1
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 14 NC_000080.7 (65049049..65187354, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 14 NC_000080.6 (64811600..64949899, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 14 NC_000080.5 (65441055..65568684, complement)

    Chromosome 14 - NC_000080.7Genomic Context describing neighboring genes Neighboring gene kinesin family member 13B Neighboring gene non-SMC element 2 homolog (MMS21, S. cerevisiae) pseudogene Neighboring gene predicted gene, 26225 Neighboring gene 60S ribosomal protein L35a pseudogene Neighboring gene high mobility group nucleosomal binding domain 2, pseudogene Neighboring gene integrator complex subunit 9 Neighboring gene predicted gene, 52118 Neighboring gene exostosin-like glycosyltransferase 3 Neighboring gene predicted gene, 52119

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Gene trapped (1) 

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables double-stranded telomeric DNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein-containing complex binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein-containing complex binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables sequence-specific DNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables sequence-specific double-stranded DNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables telomeric DNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables telomeric DNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    located_in centrosome ISO
    Inferred from Sequence Orthology
    more info
     
    located_in chromosome IEA
    Inferred from Electronic Annotation
    more info
     
    located_in chromosome, telomeric region IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in chromosome, telomeric region ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nuclear body ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    homeobox-containing protein 1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001347626.1NP_001334555.1  homeobox-containing protein 1 isoform 1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
      Source sequence(s)
      AC132602, AC141425, AK052729, AW049636
      Consensus CDS
      CCDS84150.1
      UniProtKB/Swiss-Prot
      Q8BJA3
      UniProtKB/TrEMBL
      H3BKM3
      Related
      ENSMUSP00000135448.2, ENSMUST00000176128.8
      Conserved Domains (2) summary
      cd00086
      Location:268340
      homeodomain; Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.
      pfam04814
      Location:25227
      HNF-1_N; Hepatocyte nuclear factor 1 (HNF-1), N-terminus
    2. NM_001347627.1NP_001334556.1  homeobox-containing protein 1 isoform 3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) contains two alternate exons in its 3' coding region, including an alternate 3' terminal exon, compared to variant 1. The encoded isoform (3) is shorter and has a distinct C-terminus, compared to isoform 1.
      Source sequence(s)
      AC132602, AC141425, AI604847, AK052729, CF737939
      Consensus CDS
      CCDS84149.1
      UniProtKB/Swiss-Prot
      Q8BJA3
      Related
      ENSMUSP00000022544.8, ENSMUST00000022544.14
      Conserved Domains (2) summary
      cd00086
      Location:268340
      homeodomain; Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.
      pfam04814
      Location:25227
      HNF-1_N; Hepatocyte nuclear factor 1 (HNF-1), N-terminus
    3. NM_177338.6NP_796312.2  homeobox-containing protein 1 isoform 2

      See identical proteins and their annotated locations for NP_796312.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses an alternate in-frame splice site in the 3' coding region, compared to variant 1. The encoded isoform (2) has the same N- and C-termini, but is one aa shorter than isoform 1.
      Source sequence(s)
      AC132602, AC141425, AK052729, AW049636
      Consensus CDS
      CCDS36955.1
      UniProtKB/Swiss-Prot
      Q8BJA3
      Related
      ENSMUSP00000066905.4, ENSMUST00000067843.10
      Conserved Domains (2) summary
      cd00086
      Location:268340
      homeodomain; Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.
      pfam04814
      Location:25227
      HNF-1_N; Hepatocyte nuclear factor 1 (HNF-1), N-terminus

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000080.7 Reference GRCm39 C57BL/6J

      Range
      65049049..65187354 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030247768.2XP_030103628.1  homeobox-containing protein 1 isoform X9

      Conserved Domains (2) summary
      cd00086
      Location:268340
      homeodomain; Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.
      pfam04814
      Location:25227
      HNF-1_N; Hepatocyte nuclear factor 1 (HNF-1), N-terminus
    2. XM_030247767.2XP_030103627.1  homeobox-containing protein 1 isoform X9

      Conserved Domains (2) summary
      cd00086
      Location:268340
      homeodomain; Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.
      pfam04814
      Location:25227
      HNF-1_N; Hepatocyte nuclear factor 1 (HNF-1), N-terminus
    3. XM_011245031.4XP_011243333.1  homeobox-containing protein 1 isoform X4

      Conserved Domains (2) summary
      cd00086
      Location:268340
      homeodomain; Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.
      pfam04814
      Location:25227
      HNF-1_N; Hepatocyte nuclear factor 1 (HNF-1), N-terminus
    4. XM_011245029.4XP_011243331.1  homeobox-containing protein 1 isoform X3

      Conserved Domains (2) summary
      cd00086
      Location:268340
      homeodomain; Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.
      pfam04814
      Location:25227
      HNF-1_N; Hepatocyte nuclear factor 1 (HNF-1), N-terminus
    5. XM_011245036.4XP_011243338.1  homeobox-containing protein 1 isoform X8

      See identical proteins and their annotated locations for XP_011243338.1

      UniProtKB/Swiss-Prot
      Q8BJA3
      Conserved Domains (2) summary
      cd00086
      Location:268340
      homeodomain; Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.
      pfam04814
      Location:25227
      HNF-1_N; Hepatocyte nuclear factor 1 (HNF-1), N-terminus
    6. XM_011245035.4XP_011243337.1  homeobox-containing protein 1 isoform X8

      See identical proteins and their annotated locations for XP_011243337.1

      UniProtKB/Swiss-Prot
      Q8BJA3
      Conserved Domains (2) summary
      cd00086
      Location:268340
      homeodomain; Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.
      pfam04814
      Location:25227
      HNF-1_N; Hepatocyte nuclear factor 1 (HNF-1), N-terminus
    7. XM_030247765.2XP_030103625.1  homeobox-containing protein 1 isoform X2

      Related
      ENSMUSP00000135372.3, ENSMUST00000177326.8
      Conserved Domains (2) summary
      cd00086
      Location:268340
      homeodomain; Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.
      pfam04814
      Location:25227
      HNF-1_N; Hepatocyte nuclear factor 1 (HNF-1), N-terminus
    8. XM_030247766.2XP_030103626.1  homeobox-containing protein 1 isoform X6

      Related
      ENSMUSP00000135272.2, ENSMUST00000175744.8
      Conserved Domains (2) summary
      cd00086
      Location:268340
      homeodomain; Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.
      pfam04814
      Location:25227
      HNF-1_N; Hepatocyte nuclear factor 1 (HNF-1), N-terminus
    9. XM_011245037.4XP_011243339.1  homeobox-containing protein 1 isoform X10

      Related
      ENSMUSP00000135657.3, ENSMUST00000175905.8
      Conserved Domains (2) summary
      cd00086
      Location:268340
      homeodomain; Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.
      pfam04814
      Location:25227
      HNF-1_N; Hepatocyte nuclear factor 1 (HNF-1), N-terminus
    10. XM_011245034.4XP_011243336.1  homeobox-containing protein 1 isoform X7

      See identical proteins and their annotated locations for XP_011243336.1

      UniProtKB/Swiss-Prot
      Q8BJA3
      Conserved Domains (2) summary
      cd00086
      Location:268340
      homeodomain; Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.
      pfam04814
      Location:25227
      HNF-1_N; Hepatocyte nuclear factor 1 (HNF-1), N-terminus
    11. XM_006518882.5XP_006518945.1  homeobox-containing protein 1 isoform X1

      Conserved Domains (2) summary
      cd00086
      Location:268340
      homeodomain; Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.
      pfam04814
      Location:25227
      HNF-1_N; Hepatocyte nuclear factor 1 (HNF-1), N-terminus
    12. XM_011245033.4XP_011243335.1  homeobox-containing protein 1 isoform X5

      See identical proteins and their annotated locations for XP_011243335.1

      Conserved Domains (2) summary
      cd00086
      Location:268340
      homeodomain; Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.
      pfam04814
      Location:25227
      HNF-1_N; Hepatocyte nuclear factor 1 (HNF-1), N-terminus
    13. XM_036158568.1XP_036014461.1  homeobox-containing protein 1 isoform X8

      Conserved Domains (2) summary
      cd00086
      Location:268340
      homeodomain; Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.
      pfam04814
      Location:25227
      HNF-1_N; Hepatocyte nuclear factor 1 (HNF-1), N-terminus

    RNA

    1. XR_004938387.1 RNA Sequence

    2. XR_004938386.1 RNA Sequence

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