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    Cenpj centromere protein J [ Mus musculus (house mouse) ]

    Gene ID: 219103, updated on 4-Sep-2021

    Summary

    Official Symbol
    Cenpjprovided by MGI
    Official Full Name
    centromere protein Jprovided by MGI
    Primary source
    MGI:MGI:2684927
    See related
    Ensembl:ENSMUSG00000064128
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    S; LAP; CPAP; Gm81; LIP1; Sas4; 4932437H03Rik
    Expression
    Broad expression in CNS E11.5 (RPKM 4.6), CNS E14 (RPKM 2.2) and 18 other tissues See more
    Orthologs
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    Genomic context

    See Cenpj in Genome Data Viewer
    Location:
    14; 14 C3
    Exon count:
    18
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 14 NC_000080.7 (56764218..56813009, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 14 NC_000080.6 (56526761..56575489, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 14 NC_000080.5 (57145598..57190683, complement)

    Chromosome 14 - NC_000080.7Genomic Context describing neighboring genes Neighboring gene U6 spliceosomal RNA Neighboring gene ring finger protein 17 Neighboring gene family with sequence similarity 54, member A pseudogene Neighboring gene predicted gene, 24392 Neighboring gene poly (ADP-ribose) polymerase family, member 4 Neighboring gene predicted gene 16573 Neighboring gene basic transcription factor 3, pseudogene 18

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • MGC102215

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables gamma-tubulin binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein domain specific binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein kinase binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables transcription coactivator activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables tubulin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables tubulin binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    acts_upstream_of_or_within astral microtubule nucleation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cell division IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within centriole assembly IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in centriole elongation IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in centriole elongation ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within centriole replication IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in centriole replication ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within centrosome duplication IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in cilium assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in microtubule polymerization ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within motile cilium assembly IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within non-motile cilium assembly IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of centriole elongation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of establishment of protein localization ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within positive regulation of non-motile cilium assembly IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within positive regulation of receptor signaling pathway via JAK-STAT ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of centriole replication ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within smoothened signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    is_active_in centriole IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in centriole IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in centriole ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in centrosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in centrosome ISO
    Inferred from Sequence Orthology
    more info
     
    located_in ciliary basal body IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
     
    located_in microtubule IEA
    Inferred from Electronic Annotation
    more info
     
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    centromere protein J
    Names
    CENP-J

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001014996.2NP_001014996.2  centromere protein J

      See identical proteins and their annotated locations for NP_001014996.2

      Status: VALIDATED

      Source sequence(s)
      AK077045, BC092399
      Consensus CDS
      CCDS27150.1
      UniProtKB/Swiss-Prot
      Q569L8
      Related
      ENSMUSP00000065949.8, ENSMUST00000065302.8
      Conserved Domains (4) summary
      pfam07202
      Location:11671341
      Tcp10_C; T-complex protein 10 C-terminus
      pfam07426
      Location:121183
      Dynactin_p22; Dynactin subunit p22
      pfam11819
      Location:303390
      DUF3338; Domain of unknown function (DUF3338)
      cl23720
      Location:9251044
      RILP-like; Rab interacting lysosomal protein-like 1 and 2 (Rilpl1 and Rilpl2)

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000080.7 Reference GRCm39 C57BL/6J

      Range
      56764218..56813009 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006518847.4XP_006518910.1  centromere protein J isoform X1

      See identical proteins and their annotated locations for XP_006518910.1

      Conserved Domains (4) summary
      TIGR02168
      Location:8751039
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      pfam07202
      Location:11601335
      Tcp10_C; T-complex protein 10 C-terminus
      pfam07426
      Location:121183
      Dynactin_p22; Dynactin subunit p22
      pfam11819
      Location:303390
      DUF3338; Domain of unknown function (DUF3338)
    2. XM_006518849.4XP_006518912.1  centromere protein J isoform X1

      See identical proteins and their annotated locations for XP_006518912.1

      Conserved Domains (4) summary
      TIGR02168
      Location:8751039
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      pfam07202
      Location:11601335
      Tcp10_C; T-complex protein 10 C-terminus
      pfam07426
      Location:121183
      Dynactin_p22; Dynactin subunit p22
      pfam11819
      Location:303390
      DUF3338; Domain of unknown function (DUF3338)
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