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    Cpap centrosome assembly and centriole elongation protein [ Mus musculus (house mouse) ]

    Gene ID: 219103, updated on 5-Jul-2025
    Official Symbol
    Cpapprovided by MGI
    Official Full Name
    centrosome assembly and centriole elongation proteinprovided by MGI
    Primary source
    MGI:MGI:2684927
    See related
    Ensembl:ENSMUSG00000064128 AllianceGenome:MGI:2684927
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    LAP; Gm81; LIP1; Sas4; Cenpj; 4932437H03Rik
    Summary
    Predicted to enable several functions, including gamma-tubulin binding activity; identical protein binding activity; and transcription coactivator activity. Acts upstream of or within several processes, including centriole replication; cilium assembly; and positive regulation of non-motile cilium assembly. Located in centriole and ciliary basal body. Is expressed in several structures, including brain; foregut; sensory organ; submandibular gland primordium; and tooth. Used to study Seckel syndrome. Human ortholog(s) of this gene implicated in Seckel syndrome 4; primary autosomal recessive microcephaly; and primary autosomal recessive microcephaly 6. Orthologous to human CPAP (centrosome assembly and centriole elongation protein). [provided by Alliance of Genome Resources, Jul 2025]
    Expression
    Broad expression in CNS E11.5 (RPKM 4.6), CNS E14 (RPKM 2.2) and 18 other tissues See more
    Orthologs
    NEW
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    See Cpap in Genome Data Viewer
    Location:
    14 C3; 14 28.28 cM
    Exon count:
    18
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 14 NC_000080.7 (56764218..56812950, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 14 NC_000080.6 (56526761..56575489, complement)

    Chromosome 14 - NC_000080.7Genomic Context describing neighboring genes Neighboring gene ring finger protein 17 Neighboring gene family with sequence similarity 54, member A pseudogene Neighboring gene predicted gene, 50496 Neighboring gene predicted gene, 24392 Neighboring gene STARR-seq mESC enhancer starr_36796 Neighboring gene STARR-positive B cell enhancer ABC_E10828 Neighboring gene STARR-positive B cell enhancer ABC_E5442 Neighboring gene poly (ADP-ribose) polymerase family, member 4 Neighboring gene predicted gene 16573 Neighboring gene basic transcription factor 3, pseudogene 18

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Clone Names

    • MGC102215

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables gamma-tubulin binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables gamma-tubulin binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables identical protein binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein domain specific binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein domain specific binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein kinase binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein kinase binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables transcription coactivator activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables transcription coactivator activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables tubulin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables tubulin binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables tubulin binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    acts_upstream_of_or_within astral microtubule nucleation IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within astral microtubule nucleation ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within centriole assembly IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in centriole elongation IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in centriole elongation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in centriole elongation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in centriole elongation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in centriole replication IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within centriole replication IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in centriole replication ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in centriole replication ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    acts_upstream_of_or_within centrosome duplication IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in cilium assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in microtubule polymerization IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in microtubule polymerization ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within motile cilium assembly IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within non-motile cilium assembly IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of G1/S transition of mitotic cell cycle IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of G1/S transition of mitotic cell cycle ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of centriole elongation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of centriole elongation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of centriole elongation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of centriole replication IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of centriole replication ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of establishment of protein localization IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of establishment of protein localization ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of establishment of protein localization ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    acts_upstream_of_or_within positive regulation of non-motile cilium assembly IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of organelle assembly IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within positive regulation of receptor signaling pathway via JAK-STAT IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within positive regulation of receptor signaling pathway via JAK-STAT ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of spindle assembly NAS
    Non-traceable Author Statement
    more info
    PubMed 
    involved_in regulation of centriole replication IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in regulation of centriole replication ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of centriole replication ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in regulation of mitotic spindle organization NAS
    Non-traceable Author Statement
    more info
    PubMed 
    acts_upstream_of_or_within smoothened signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    is_active_in centriole IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in centriole IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in centriole IEA
    Inferred from Electronic Annotation
    more info
     
    located_in centriole ISO
    Inferred from Sequence Orthology
    more info
     
    located_in centriole ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    is_active_in centrosome IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in centrosome IEA
    Inferred from Electronic Annotation
    more info
     
    located_in centrosome ISO
    Inferred from Sequence Orthology
    more info
     
    located_in ciliary basal body IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
     
    located_in microtubule IEA
    Inferred from Electronic Annotation
    more info
     
    part_of procentriole replication complex IEA
    Inferred from Electronic Annotation
    more info
     
    part_of procentriole replication complex ISO
    Inferred from Sequence Orthology
    more info
     
    Preferred Names
    centrosomal P4.1-associated protein; centromere protein J
    Names
    CENP-J

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001014996.3NP_001014996.2  centrosomal P4.1-associated protein isoform 1

      See identical proteins and their annotated locations for NP_001014996.2

      Status: VALIDATED

      Source sequence(s)
      AC154837
      Consensus CDS
      CCDS27150.1
      UniProtKB/Swiss-Prot
      E9QLP3, Q569L8
      Related
      ENSMUSP00000065949.8, ENSMUST00000065302.8
      Conserved Domains (2) summary
      TIGR02169
      Location:9051060
      SMC_prok_A; chromosome segregation protein SMC, primarily archaeal type
      pfam07202
      Location:11581186
      Tcp10_C; T-complex protein 10 C-terminus
    2. NM_001403533.1NP_001390462.1  centrosomal P4.1-associated protein isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC154837
    3. NM_001403534.1NP_001390463.1  centrosomal P4.1-associated protein isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC154837

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000080.7 Reference GRCm39 C57BL/6J

      Range
      56764218..56812950 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006518849.4XP_006518912.1  centromere protein J isoform X1

      See identical proteins and their annotated locations for XP_006518912.1

      Conserved Domains (4) summary
      TIGR02168
      Location:8751039
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      pfam07202
      Location:11601335
      Tcp10_C; T-complex protein 10 C-terminus
      pfam07426
      Location:121183
      Dynactin_p22; Dynactin subunit p22
      pfam11819
      Location:303390
      DUF3338; Domain of unknown function (DUF3338)