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    Pip4p1 phosphatidylinositol-4,5-bisphosphate 4-phosphatase 1 [ Mus musculus (house mouse) ]

    Gene ID: 219024, updated on 23-Jun-2021

    Summary

    Official Symbol
    Pip4p1provided by MGI
    Official Full Name
    phosphatidylinositol-4,5-bisphosphate 4-phosphatase 1provided by MGI
    Primary source
    MGI:MGI:2448501
    See related
    Ensembl:ENSMUSG00000035953
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Tmem55b; BC039161
    Expression
    Ubiquitous expression in adrenal adult (RPKM 44.4), mammary gland adult (RPKM 32.3) and 28 other tissues See more
    Orthologs
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    Genomic context

    See Pip4p1 in Genome Data Viewer
    Location:
    14; 14 C1
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 14 NC_000080.7 (51164672..51168306, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 14 NC_000080.6 (50927215..50931010, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 14 NC_000080.5 (51545745..51550524, complement)

    Chromosome 14 - NC_000080.7Genomic Context describing neighboring genes Neighboring gene O-sialoglycoprotein endopeptidase Neighboring gene Apex1 promoter region Neighboring gene apurinic/apyrimidinic endonuclease 1 Neighboring gene predicted gene, 52117 Neighboring gene purine-nucleoside phosphorylase Neighboring gene predicted gene, 38316 Neighboring gene purine-nucleoside phosphorylase 2

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (1) 
    • Endonuclease-mediated (1) 

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • MGC118137

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables phosphatidylinositol-4,5-bisphosphate 4-phosphatase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables phosphatidylinositol-4,5-bisphosphate 4-phosphatase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in cytoplasmic vesicle IEA
    Inferred from Electronic Annotation
    more info
     
    located_in endosome IEA
    Inferred from Electronic Annotation
    more info
     
    located_in integral component of membrane IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in late endosome membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in late endosome membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in late endosome membrane ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in lysosomal membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in lysosomal membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in lysosomal membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in lysosome IEA
    Inferred from Electronic Annotation
    more info
     
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in phagocytic vesicle membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in phagocytic vesicle membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    type 1 phosphatidylinositol 4,5-bisphosphate 4-phosphatase
    Names
    PtdIns-4,5-P(2) 4-phosphatase type I
    ptdIns-4,5-P2 4-Ptase I
    transmembrane protein 55b
    type 1 PtdIns-4,5-P2 4-Ptase
    type I phosphatidylinositol 4,5-bisphosphate 4-phosphatase
    NP_001028443.1
    NP_001297434.1
    NP_001297435.1
    NP_001297436.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001033271.5NP_001028443.1  type 1 phosphatidylinositol 4,5-bisphosphate 4-phosphatase isoform 1

      See identical proteins and their annotated locations for NP_001028443.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AK144251, BE943635
      Consensus CDS
      CCDS27028.1
      UniProtKB/Swiss-Prot
      Q3TWL2
      Related
      ENSMUSP00000124782.2, ENSMUST00000160835.9
      Conserved Domains (1) summary
      pfam09788
      Location:4277
      Tmemb_55A; Transmembrane protein 55A
    2. NM_001310505.1NP_001297434.1  type 1 phosphatidylinositol 4,5-bisphosphate 4-phosphatase isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses an alternate in-frame splice site in the 5' coding region, compared to variant 1. It encodes isoform 2, which is shorter than isoform 1.
      Source sequence(s)
      AK144251, BE943635, BY071053
      Consensus CDS
      CCDS79324.1
      UniProtKB/Swiss-Prot
      Q3TWL2
      UniProtKB/TrEMBL
      F8WHW3
      Related
      ENSMUSP00000038276.8, ENSMUST00000049312.14
      Conserved Domains (1) summary
      pfam09788
      Location:4270
      Tmemb_55A; Transmembrane protein 55A
    3. NM_001310506.1NP_001297435.1  type 1 phosphatidylinositol 4,5-bisphosphate 4-phosphatase isoform 3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) lacks an alternate exon in the central coding region, which results in a frameshift, compared to variant 1. It encodes isoform 3, which is shorter and has a distinct central region and C-terminus compared to isoform 1.
      Source sequence(s)
      AK144251, BE943635
      Consensus CDS
      CCDS79322.1
      UniProtKB/Swiss-Prot
      Q3TWL2
      UniProtKB/TrEMBL
      E0CZ18
      Related
      ENSMUSP00000123697.2, ENSMUST00000162957.8
      Conserved Domains (1) summary
      pfam09788
      Location:4154
      Tmemb_55A; Transmembrane protein 55A
    4. NM_001310507.1NP_001297436.1  type 1 phosphatidylinositol 4,5-bisphosphate 4-phosphatase isoform 4

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) uses an alternate in-frame splice site in the 5' coding region and lacks an alternate exon in the central coding region, which results in a frameshift, compared to variant 1. It encodes isoform 4, which is shorter and has a distinct central region and C-terminus compared to isoform 1.
      Source sequence(s)
      AK144251, BE943635, CX240137
      Consensus CDS
      CCDS79323.1
      UniProtKB/Swiss-Prot
      Q3TWL2
      UniProtKB/TrEMBL
      E0CZF6
      Related
      ENSMUSP00000125414.2, ENSMUST00000161166.8
      Conserved Domains (1) summary
      pfam09788
      Location:4147
      Tmemb_55A; Transmembrane protein 55A

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000080.7 Reference GRCm39 C57BL/6J

      Range
      51164672..51168306 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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