Format

Send to:

Choose Destination
    • Showing Current items.

    Fermt2 fermitin family member 2 [ Mus musculus (house mouse) ]

    Gene ID: 218952, updated on 11-Nov-2018

    Summary

    Official Symbol
    Fermt2provided by MGI
    Official Full Name
    fermitin family member 2provided by MGI
    Primary source
    MGI:MGI:2385001
    See related
    Ensembl:ENSMUSG00000037712 Vega:OTTMUSG00000026135
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Mig2; Plekhc1; AA960555; Kindlin-2
    Expression
    Broad expression in bladder adult (RPKM 89.4), placenta adult (RPKM 48.8) and 21 other tissues See more
    Orthologs

    Genomic context

    See Fermt2 in Genome Data Viewer
    Location:
    14; 14 C1
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 14 NC_000080.6 (45458792..45530113, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 14 NC_000080.5 (46078467..46149740, complement)

    Chromosome 14 - NC_000080.6Genomic Context describing neighboring genes Neighboring gene predicted gene, 41143 Neighboring gene predicted gene, 34250 Neighboring gene RIKEN cDNA 4930527F14 gene Neighboring gene predicted gene, 46452 Neighboring gene predicted gene, 41144 Neighboring gene predicted pseudogene 5206

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from BioSystems

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • MGC36305

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    actin filament binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    lipid binding IEA
    Inferred from Electronic Annotation
    more info
     
    phosphatidylinositol-3,4,5-trisphosphate binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    Wnt signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    cell adhesion IEA
    Inferred from Electronic Annotation
    more info
     
    cell-matrix adhesion IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    cell-matrix adhesion ISO
    Inferred from Sequence Orthology
    more info
     
    focal adhesion assembly IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    integrin activation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    integrin activation ISO
    Inferred from Sequence Orthology
    more info
     
    integrin-mediated signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    protein localization to membrane IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of cell shape IEA
    Inferred from Electronic Annotation
    more info
     
    substrate adhesion-dependent cell spreading IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    transforming growth factor beta receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    cell junction IEA
    Inferred from Electronic Annotation
    more info
     
    cell projection IEA
    Inferred from Electronic Annotation
    more info
     
    cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
     
    extrinsic component of cytoplasmic side of plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    focal adhesion ISO
    Inferred from Sequence Orthology
    more info
     
    membrane IEA
    Inferred from Electronic Annotation
    more info
     
    nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    plasma membrane IEA
    Inferred from Electronic Annotation
    more info
     
    colocalizes_with stress fiber IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    fermitin family homolog 2
    Names
    mitogen inducible 2
    pleckstrin homology domain containing, family C (with FERM domain) member 1
    pleckstrin homology domain-containing family C member 1

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001360525.1NP_001347454.1  fermitin family homolog 2 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC102445, AK166552, BB669826, BY241982, CT025535, CX201801, CX242997
      Conserved Domains (4) summary
      cd01237
      Location:384508
      PH_fermitin; Fermitin family pleckstrin homology (PH) domain
      pfam00373
      Location:520584
      FERM_M; FERM central domain
      cl09511
      Location:252312
      FERM_B-lobe; FERM domain B-lobe
      cl17171
      Location:578669
      PH-like; Pleckstrin homology-like domain
    2. NM_001360526.1NP_001347455.1  fermitin family homolog 2 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC102445, AK166552, BB669826, BY241982, CT025535, CX201801
      Conserved Domains (4) summary
      cd01237
      Location:373497
      PH_fermitin; Fermitin family pleckstrin homology (PH) domain
      pfam00373
      Location:509580
      FERM_M; FERM central domain
      cl09511
      Location:241301
      FERM_B-lobe; FERM domain B-lobe
      cl17171
      Location:574665
      PH-like; Pleckstrin homology-like domain
    3. NM_146054.3NP_666166.2  fermitin family homolog 2 isoform 3

      See identical proteins and their annotated locations for NP_666166.2

      Status: VALIDATED

      Source sequence(s)
      AC102445, AK166552, BB669826, BY241982, CT025535, CX201801
      Consensus CDS
      CCDS26977.1
      UniProtKB/Swiss-Prot
      Q8CIB5
      UniProtKB/TrEMBL
      Q3TLE2
      Related
      ENSMUSP00000044554.6, OTTMUSP00000032080, ENSMUST00000045905.13
      Conserved Domains (4) summary
      cd01237
      Location:373497
      PH_fermitin; Fermitin family pleckstrin homology (PH) domain
      pfam00169
      Location:381476
      PH; PH domain
      pfam00373
      Location:509573
      FERM_M; FERM central domain
      cl17171
      Location:567658
      PH-like; Pleckstrin homology-like domain

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000080.6 Reference GRCm38.p4 C57BL/6J

      Range
      45458792..45530113 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006518828.2XP_006518891.2  fermitin family homolog 2 isoform X3

      Conserved Domains (4) summary
      cd01237
      Location:373497
      PH_fermitin; Fermitin family pleckstrin homology (PH) domain
      pfam00373
      Location:509580
      FERM_M; FERM central domain
      cl09511
      Location:241301
      FERM_B-lobe; FERM domain B-lobe
      cl17171
      Location:574665
      PH-like; Pleckstrin homology-like domain
    2. XM_006518827.2XP_006518890.2  fermitin family homolog 2 isoform X2

      Conserved Domains (4) summary
      cd01237
      Location:384508
      PH_fermitin; Fermitin family pleckstrin homology (PH) domain
      pfam00373
      Location:520584
      FERM_M; FERM central domain
      cl09511
      Location:252312
      FERM_B-lobe; FERM domain B-lobe
      cl17171
      Location:578669
      PH-like; Pleckstrin homology-like domain
    3. XM_006518826.2XP_006518889.2  fermitin family homolog 2 isoform X1

      Conserved Domains (4) summary
      cd01237
      Location:384508
      PH_fermitin; Fermitin family pleckstrin homology (PH) domain
      pfam00169
      Location:392487
      PH; PH domain
      pfam00373
      Location:520591
      FERM_M; FERM central domain
      cl17171
      Location:585676
      PH-like; Pleckstrin homology-like domain
    Support Center