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    Wapl WAPL cohesin release factor [ Mus musculus (house mouse) ]

    Gene ID: 218914, updated on 23-Jun-2021

    Summary

    Official Symbol
    Waplprovided by MGI
    Official Full Name
    WAPL cohesin release factorprovided by MGI
    Primary source
    MGI:MGI:2675859
    See related
    Ensembl:ENSMUSG00000041408
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    W; FOE; DIF-2; Wapal; BC037674; A530089A20Rik
    Summary
    Studies suggest that the protein encoded by this gene is important for the release of cohesin from chromatin. This gene product is thought to be essential for development, and reduced expression of this gene in cells causes defects in chromatin structure. High levels of expression of the human ortholog of this gene are observed in cervical cancers, and expression of the human ortholog of this gene in mice results in tumor formation. Alternative splicing results in multiple transcript variants encoding different protein isoforms. [provided by RefSeq, Aug 2014]
    Expression
    Ubiquitous expression in liver E14 (RPKM 13.4), placenta adult (RPKM 11.9) and 28 other tissues See more
    Orthologs
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    Genomic context

    See Wapl in Genome Data Viewer
    Location:
    14; 14 B
    Exon count:
    19
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 14 NC_000080.7 (34394086..34469940)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 14 NC_000080.6 (34672379..34747983)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 14 NC_000080.5 (35487114..35559403)

    Chromosome 14 - NC_000080.7Genomic Context describing neighboring genes Neighboring gene opsin 4 (melanopsin) Neighboring gene predicted gene, 52113 Neighboring gene RIKEN cDNA 5830448L01 gene Neighboring gene RIKEN cDNA A930038B10 gene Neighboring gene predicted gene, 52101 Neighboring gene predicted gene, 30969

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • KIAA0261

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
     
    Process Evidence Code Pubs
    acts_upstream_of_or_within cell cycle IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within cell division IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within mitotic cell cycle IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    acts_upstream_of_or_within mitotic cell cycle IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of DNA replication ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of chromatin binding ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of sister chromatid cohesion ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within positive regulation of fibroblast proliferation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in protein localization to chromatin ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of chromosome condensation IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    acts_upstream_of_or_within regulation of chromosome condensation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within regulation of chromosome segregation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in regulation of cohesin loading IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    acts_upstream_of_or_within regulation of cohesin loading IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in regulation of cohesin loading ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within response to toxic substance IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in Golgi apparatus ISO
    Inferred from Sequence Orthology
    more info
     
    located_in centrosome ISO
    Inferred from Sequence Orthology
    more info
     
    located_in chromatin IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in chromatin ISO
    Inferred from Sequence Orthology
    more info
     
    located_in chromosome IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    located_in intercellular bridge ISO
    Inferred from Sequence Orthology
    more info
     
    located_in mitotic spindle ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    located_in synaptonemal complex IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    wings apart-like protein homolog
    Names
    dioxin-inducible factor 2
    friend of EBNA2
    wings apart-like homolog

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001004436.4NP_001004436.2  wings apart-like protein homolog isoform 1

      See identical proteins and their annotated locations for NP_001004436.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      BC139434, BG068179, BP757948, BY732412, CJ053978, CJ061782, CJ134128, DV646537, DV659439
      Consensus CDS
      CCDS36880.1
      UniProtKB/Swiss-Prot
      Q65Z40
      Related
      ENSMUSP00000040232.8, ENSMUST00000048263.14
      Conserved Domains (1) summary
      pfam07814
      Location:6471008
      WAPL; Wings apart-like protein regulation of heterochromatin
    2. NM_001301330.1NP_001288259.1  wings apart-like protein homolog isoform 2

      See identical proteins and their annotated locations for NP_001288259.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) uses an alternate in-frame splice site in the coding region, compared to variant 1. This results in a shorter protein (isoform 2), compared to isoform 1.
      Source sequence(s)
      BC139434, BG068179, BP757948, BY732412, CF161743, CJ053978, CJ061782, CJ134128, DV646537, DV659439
      Consensus CDS
      CCDS79296.1
      UniProtKB/Swiss-Prot
      Q65Z40
      UniProtKB/TrEMBL
      B7ZP47
      Related
      ENSMUSP00000087481.4, ENSMUST00000090027.11
      Conserved Domains (1) summary
      pfam07814
      Location:6411002
      WAPL; Wings apart-like protein regulation of heterochromatin

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000080.7 Reference GRCm39 C57BL/6J

      Range
      34394086..34469940
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006518824.5XP_006518887.1  wings apart-like protein homolog isoform X1

      Conserved Domains (1) summary
      pfam07814
      Location:596957
      WAPL; Wings apart-like protein regulation of heterochromatin
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